Protein: PKHF2
Pleckstrin homology domain-containing family F member 2 (PH domain-containing family F member 2) (Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains) (EAPF) (PH and FYVE domain-containing protein 2) (Phafin-2) (Phafin2) (Zinc finger FYVE domain-containing protein 18)

Gene: PKHF2, PLEKHF2
Organism: Homo sapiens
Interactions: 179
UniProt ID: Q9H8W4

Gene Ontology (top 5):
GO:0005769 - early endosome
GO:0005783 - endoplasmic reticulum
GO:0007032 - endosome organization
GO:0008333 - endosome to lysosome transport
GO:0015031 - protein transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

273526

ADAP1
Arf-GAP with dual PH domain-containing protein 1

2

2

High-throughput

0.783

High

972254

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

2

High-throughput

0.783

High

1148034

ZFY26
Zinc finger FYVE domain-containing protein 26

2

13

High-throughput

0.783

High

1333874

DP13A
DCC-interacting protein 13-alpha

1

1

High-throughput

0.723

High

845909

RAB28
Ras-related protein Rab-28

2

8

High-throughput

0.700

High

874337

GEM
GTP-binding protein GEM

2

7

High-throughput

0.700

High

1205208

CD20B
Cell division cycle protein 20 homolog B

2

2

High-throughput

0.700

High

1296169

SCYL1
N-terminal kinase-like protein

2

2

High-throughput

0.700

High

1315995

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

2

1

High-throughput

0.700

High

1333863

PK1IP
p21-activated protein kinase-interacting protein 1

2

6

High-throughput

0.700

High

1282425

FBXW5
F-box/WD repeat-containing protein 5

2

0

High-throughput

0.655

High

1333873

PRAF1
Prenylated Rab acceptor protein 1

2

1

High-throughput

0.640

High

549232

ZN250
Zinc finger protein 250

2

3

High-throughput

0.633

High

1293461

ACY3
N-acyl-aromatic-L-amino acid amidohydrolase

2

1

High-throughput

0.628

High

1197563

NPM2
Nucleoplasmin-2

3

4

High-throughput

0.616

High

1295440

LMBL3
Lethal(3)malignant brain tumor-like protein 3

3

2

High-throughput

0.616

High

1317689

FRMD8
FERM domain-containing protein 8

3

2

High-throughput

0.616

High

320734

LDOC1
Protein LDOC1

3

1

High-throughput

0.613

High

898196

MAX
Protein max

3

4

High-throughput

0.609

High

1333335

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

3

2

High-throughput

0.609

High

331885

NSD2
Histone-lysine N-methyltransferase NSD2

2

5

High-throughput

0.606

High

632911

TYY1
Transcriptional repressor protein YY1

2

4

High-throughput

0.606

High

836610

ZN165
Zinc finger protein 165

2

3

High-throughput

0.606

High

1012176

RGF1B
Ras-GEF domain-containing family member 1B

2

1

High-throughput

0.606

High

1080650

ZBTB6
Zinc finger and BTB domain-containing protein 6

2

4

High-throughput

0.606

High

1166363

ZDH24
Probable palmitoyltransferase ZDHHC24

2

1

High-throughput

0.606

High

1242551

ZN439
Zinc finger protein 439

2

5

High-throughput

0.606

High

1333867

ZN581
Zinc finger protein 581

2

4

High-throughput

0.606

High

1333876

BL1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6

2

0

High-throughput

0.601

High

2799

A0A0C4DGQ7
EMAP like 2

1

2

High-throughput

0.594

High

985584

Q05BL1
TP53BP2 protein

1

12

High-throughput

0.594

High

1027438

STK3
Serine/threonine-protein kinase 3

1

1

High-throughput

0.594

High

1127745

RAB41
Ras-related protein Rab-41

1

19

High-throughput

0.594

High

312767

TFIP8
Tumor necrosis factor alpha-induced protein 8

2

2

High-throughput

0.584

High

498352

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

1

High-throughput

0.584

High

1333875

CHIC2
Cysteine-rich hydrophobic domain-containing protein 2

2

1

High-throughput

0.584

High

1333869

HSPB7
Heat shock protein beta-7

2

1

High-throughput

0.583

High

303955

YIF1A
Protein YIF1A

2

0

High-throughput

0.580

High

495760

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

2

0

High-throughput

0.580

High

562865

FAAA
Fumarylacetoacetase

2

0

High-throughput

0.580

High

1016682

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.580

High

1088335

UGPA
UTP--glucose-1-phosphate uridylyltransferase

2

0

High-throughput

0.580

High

1221365

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

2

0

High-throughput

0.580

High

1284582

RPE
Ribulose-phosphate 3-epimerase

2

0

High-throughput

0.580

High

1291260

STALP
AMSH-like protease

2

0

High-throughput

0.580

High

1312757

SPON2
Spondin-2

2

0

High-throughput

0.580

High

1327519

XRN2
5'-3' exoribonuclease 2

2

0

High-throughput

0.580

High

1332531

BCAS3
BCAS3 microtubule associated cell migration factor

2

0

High-throughput

0.580

High

1333859

DMRT3
Doublesex- and mab-3-related transcription factor 3

2

0

High-throughput

0.580

High

1333868

THA10
THAP domain-containing protein 10

2

0

High-throughput

0.580

High

1333879

TRAF6
TNF receptor-associated factor 6

2

9

High-throughput

0.578

High

1254341

ZN398
Zinc finger protein 398

1

4

High-throughput

0.573

High

1304743

S10AD
Protein S100-A13

1

5

High-throughput

0.573

High

325573

EMAL2
Echinoderm microtubule-associated protein-like 2

1

3

High-throughput

0.555

High

1043756

ASPP2
Apoptosis-stimulating of p53 protein 2

1

12

High-throughput

0.555

High

210417

RGS10
Regulator of G-protein signaling 10

2

2

High-throughput

0.553

High

278536

SPF27
Pre-mRNA-splicing factor SPF27

2

1

High-throughput

0.553

High

488024

RARA
Retinoic acid receptor alpha

2

9

High-throughput

0.553

High

598325

FLNA
Filamin-A

2

11

High-throughput

0.553

High

640274

PTN3
Tyrosine-protein phosphatase non-receptor type 3

2

4

High-throughput

0.553

High

802291

XCR1
Chemokine XC receptor 1

2

1

High-throughput

0.553

High

871068

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

2

3

High-throughput

0.553

High

885009

RGS8
Regulator of G-protein signaling 8

2

2

High-throughput

0.553

High

1018268

NFIA
Nuclear factor 1 A-type

2

1

High-throughput

0.553

High

1024835

DUS4
Dual specificity protein phosphatase 4

2

1

High-throughput

0.553

High

1065187

DAZP2
DAZ-associated protein 2

2

2

High-throughput

0.553

High

1083189

U1SBP
U11/U12 small nuclear ribonucleoprotein 35 kDa protein

2

5

High-throughput

0.553

High

1117704

ARI4B
AT-rich interactive domain-containing protein 4B

2

2

High-throughput

0.553

High

1119630

MIDN
Midnolin

2

1

High-throughput

0.553

High

1129753

TBCEL
Tubulin-specific chaperone cofactor E-like protein

2

3

High-throughput

0.553

High

1154239

KRA54
Keratin-associated protein 5-4

2

1

High-throughput

0.553

High

1157453

PPR18
Phostensin

2

1

High-throughput

0.553

High

1199791

MAGI2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

2

6

High-throughput

0.553

High

1204015

DAA11
Dynein axonemal assembly factor 11

2

8

High-throughput

0.553

High

1223052

CC146
Coiled-coil domain-containing protein 146

2

15

High-throughput

0.553

High

1223390

TRI22
E3 ubiquitin-protein ligase TRIM22

2

9

High-throughput

0.553

High

1224233

DOCK3
Dedicator of cytokinesis protein 3

2

2

High-throughput

0.553

High

1234867

TTC9C
Tetratricopeptide repeat protein 9C

2

3

High-throughput

0.553

High

1237644

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

1

High-throughput

0.553

High

1253808

CERK1
Ceramide kinase

2

2

High-throughput

0.553

High

1261695

TP8L1
Tumor necrosis factor alpha-induced protein 8-like protein 1

2

2

High-throughput

0.553

High

1267441

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

9

High-throughput

0.553

High

1267945

DOCK2
Dedicator of cytokinesis protein 2

2

2

High-throughput

0.553

High

1272775

FGF13
Fibroblast growth factor 13

2

2

High-throughput

0.553

High

1298459

PWP2A
PWWP domain-containing protein 2A

2

1

High-throughput

0.553

High

1298910

SAM11
Sterile alpha motif domain-containing protein 11

2

2

High-throughput

0.553

High

1304623

P2RX7
P2X purinoceptor 7

2

1

High-throughput

0.553

High

1314933

GTPB2
GTP-binding protein 2

2

5

High-throughput

0.553

High

1333856

CBX8
Chromobox protein homolog 8

2

5

High-throughput

0.553

High

1333857

BRD7
Bromodomain-containing protein 7

2

3

High-throughput

0.553

High

1333860

RPRM
Protein reprimo

2

1

High-throughput

0.553

High

1333866

BARH2
BarH-like 2 homeobox protein

2

2

High-throughput

0.553

High

1333877

INO80
Chromatin-remodeling ATPase INO80

2

2

High-throughput

0.553

High

1333878

EXOC7
Exocyst complex component 7

2

1

High-throughput

0.553

High

208749

TPPC3
Trafficking protein particle complex subunit 3

1

0

High-throughput

0.549

High

161875

ZN263
Zinc finger protein 263

1

6

High-throughput

0.541

High

307126

RTN3
Reticulon-3

1

4

High-throughput

0.541

High

543073

GLNA
Glutamine synthetase

1

1

High-throughput

0.541

High

1087798

RTN1
Reticulon-1

1

4

High-throughput

0.541

High

1333858

RTN4
Reticulon-4

1

4

High-throughput

0.541

High

615226

S10A1
Protein S100-A1

1

5

High-throughput

0.523

High

1049013

SEPT6
Septin-6

1

5

High-throughput

0.523

High

1063186

SEPT2
Septin-2

1

5

High-throughput

0.523

High

1166816

RSPO2
R-spondin-2

1

6

High-throughput

0.523

High

1200348

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

2

High-throughput

0.523

High

1203339

GPBP1
Vasculin

1

1

High-throughput

0.523

High

1286570

Q96C98
FHL3 protein

1

4

High-throughput

0.515

High

395792

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.501

High

323505

CAVN2
Caveolae-associated protein 2

1

1

High-throughput

0.494

High

684332

1433S
14-3-3 protein sigma

1

20

High-throughput

0.494

High

1055357

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

1

1

High-throughput

0.494

High

1069798

NONO
Non-POU domain-containing octamer-binding protein

1

3

High-throughput

0.494

High

1333855

GPBL1
Vasculin-like protein 1

1

1

High-throughput

0.494

High

1246369

THOC2
THO complex subunit 2

1

5

High-throughput

0.489

High

1285551

AIDA
Axin interactor, dorsalization-associated protein

1

0

High-throughput

0.486

High

1044705

FHL3
Four and a half LIM domains protein 3

1

3

High-throughput

0.481

High

1326817

PRD14
PR domain zinc finger protein 14

1

4

High-throughput

0.481

High

1333872

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

58479

A2RU80
MPP4 protein

1

3

High-throughput

0.470

High

607838

USF1
Upstream stimulatory factor 1

1

4

High-throughput

0.464

High

1060232

NC2A
Dr1-associated corepressor

1

2

High-throughput

0.464

High

1305899

SEPT5
Septin-5

1

5

High-throughput

0.464

High

168148

TBX3
T-box transcription factor TBX3

1

2

High-throughput

0.439

High

477817

GG12I
G antigen 12I

1

1

High-throughput

0.439

High

1118289

GAG2E
G antigen 2E

1

1

High-throughput

0.439

High

1205193

NUTM1
NUT family member 1

1

2

High-throughput

0.439

High

1295086

MPP4
MAGUK p55 subfamily member 4

1

4

High-throughput

0.439

High

1333861

MBIP1
MAP3K12-binding inhibitory protein 1

3

0

High-throughput

0.358

High

1333862

FBX28
F-box only protein 28

3

0

High-throughput

0.352

High

1333883

SETBP
SET-binding protein

3

0

High-throughput

0.352

High

1333880

SPEF1
Sperm flagellar protein 1

3

0

High-throughput

0.348

High

1333854

EAF6
Chromatin modification-related protein MEAF6

2

0

High-throughput

0.339

High

49717

ANO9
Anoctamin-9

2

0

High-throughput

0.316

High

203574

KCAB3
Voltage-gated potassium channel subunit beta-3

2

0

High-throughput

0.316

High

212025

TRIA1
TP53-regulated inhibitor of apoptosis 1

2

0

High-throughput

0.316

High

344713

CO3
Complement C3

2

0

High-throughput

0.316

High

362106

MBP
Myelin basic protein

2

0

High-throughput

0.316

High

409355

CRBA1
Beta-crystallin A3 [Cleaved into: Beta-crystallin A3, isoform A1, Delta4 form; Beta-crystallin A3, isoform A1, Delta7 form; Beta-crystallin A3, isoform A1, Delta8 form]

2

0

High-throughput

0.316

High

841058

AP4A
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

2

0

High-throughput

0.316

High

875745

MFAP1
Microfibrillar-associated protein 1

2

0

High-throughput

0.316

High

887747

KR10A
Keratin-associated protein 10-10

2

0

High-throughput

0.316

High

929251

RS21
Small ribosomal subunit protein eS21

2

0

High-throughput

0.316

High

1085249

PDK4
[Pyruvate dehydrogenase

2

0

High-throughput

0.316

High

1086496

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

2

0

High-throughput

0.316

High

1089415

SYT16
Synaptotagmin-16

2

0

High-throughput

0.316

High

1152442

GRAM4
GRAM domain-containing protein 4

2

0

High-throughput

0.316

High

1202909

SPA24
Spermatogenesis-associated protein 24

2

0

High-throughput

0.316

High

1203362

CCD25
Coiled-coil domain-containing protein 25

2

0

High-throughput

0.316

High

1235415

TR1L1
Translocating chain-associated membrane protein 1-like 1

2

0

High-throughput

0.316

High

1251823

KC5S1
Uncharacterized protein KCNJ5-AS1

2

0

High-throughput

0.316

High

1286633

COAC
Phosphopantothenoylcysteine decarboxylase

2

0

High-throughput

0.316

High

1294516

BOD1
Biorientation of chromosomes in cell division protein 1

2

0

High-throughput

0.316

High

1305018

EIF3C
Eukaryotic translation initiation factor 3 subunit C

2

0

High-throughput

0.316

High

1309360

SOST
Sclerostin

2

0

High-throughput

0.316

High

1312620

MMTA2
Multiple myeloma tumor-associated protein 2

2

0

High-throughput

0.316

High

1313408

MTNA
Methylthioribose-1-phosphate isomerase

2

0

High-throughput

0.316

High

1328505

ABCG4
ATP-binding cassette sub-family G member 4

2

0

High-throughput

0.316

High

1333864

THG1
Probable tRNA(His) guanylyltransferase

2

0

High-throughput

0.316

High

1333870

S14L4
SEC14-like protein 4

2

0

High-throughput

0.316

High

1333881

HEBP2
Heme-binding protein 2

2

0

High-throughput

0.316

High

1333882

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

2

0

High-throughput

0.316

High

878615

ALR
FAD-linked sulfhydryl oxidase ALR

1

0

High-throughput

0.299

High

1026361

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.299

High

1291986

BSCL2
Seipin

1

0

High-throughput

0.299

High

1319322

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.299

High

1333865

TXN4B
Thioredoxin-like protein 4B

1

0

High-throughput

0.299

High

704285

DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

1

0

High-throughput

0.292

High

1237271

BEND7
BEN domain-containing protein 7

1

0

High-throughput

0.292

High

1058914

GNMT
Glycine N-methyltransferase

1

0

High-throughput

0.282

High

1079297

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.282

High

1304679

T22D3
TSC22 domain family protein 3

1

0

High-throughput

0.282

High

571214

EGLN
Endoglin

1

0

High-throughput

0.279

Low

174313

TELT
Telethonin

1

0

High-throughput

0.268

Low

1123112

KHDC3
KH domain-containing protein 3

1

0

High-throughput

0.268

Low

473629

CC172
Coiled-coil domain-containing protein 172

1

0

High-throughput

0.265

Low

1155820

RADX
RPA-related protein RADX

1

0

High-throughput

0.265

Low

1183778

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.265

Low

1333871

CGBP1
CGG triplet repeat-binding protein 1

1

0

High-throughput

0.265

Low

1237862

AL14E
ARL14 effector protein

1

0

High-throughput

0.251

Low


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Last updated: 15 Jul 2024