HitPredict

Interactor 1: TCPE (P48643)
T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5)
Gene: CCT5

Interactor 2: FBXW8 (Q8N3Y1)
F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29)
Gene: FBXW8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 37689310
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 541 Hs			1 598
+	Hs
		826762 TCPG_HUMAN (14-540): 0: 572: 33.15		FBXW8_HUMAN (1-598): 4.17e-132: 400: 96.17
+	Hs
		826807 TCPG_HUMAN (14-540): 0: 572: 33.15		FBXW7_HUMAN (285-590): 1.43e-81: 272: 13.88
+	Hs
		821291 TCPE_HUMAN (1-541): 0: 635: 100.00		WDR86_HUMAN (64-420): 1.44e-55: 194: 13.30
+	Hs
		821387 TCPE_HUMAN (1-541): 0: 635: 100.00		TBL1Y_HUMAN (329-589): 8.89e-51: 185: 11.93
+	Hs
		821437 TCPE_HUMAN (1-541): 0: 635: 100.00		NLE1_HUMAN (374-598): 6.99e-46: 170: 10.26
+	Hs
		821326 TCPE_HUMAN (1-541): 0: 635: 100.00		POC1B_HUMAN (428-590): 8.43e-39: 150: 15.39
+	Hs
		826743 TCPG_HUMAN (14-540): 0: 572: 33.15		WDR86_HUMAN (64-420): 1.44e-55: 194: 13.30
+	Hs
		821468 TCPE_HUMAN (1-541): 0: 635: 100.00		FBW1A_HUMAN (421-593): 2.84e-31: 130: 17.22
+	Hs
		1198554 TCPH_HUMAN (12-539): 0: 570: 29.64		WDR86_HUMAN (64-420): 1.44e-55: 194: 13.30
+	Hs
		826748 TCPG_HUMAN (14-540): 0: 572: 33.15		WDR5B_HUMAN (40-372): 8.51e-54: 188: 13.41
+	Hs
		826848 TCPG_HUMAN (14-540): 0: 572: 33.15		TBL1Y_HUMAN (329-589): 8.89e-51: 185: 11.93
+	Hs
		821152 TCPE_HUMAN (1-541): 0: 635: 100.00		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Hs
		792942 TCPG_HUMAN (14-540): 0: 572: 33.15		LIS1_HUMAN (6-327): 3.89e-44: 164: 11.60
+	Hs
		826784 TCPG_HUMAN (14-540): 0: 572: 33.15		POC1B_HUMAN (428-590): 8.43e-39: 150: 15.39
+	Hs
		821316 TCPE_HUMAN (1-541): 0: 635: 100.00		POC1A_HUMAN (71-262): 1.3e-15: 81.1: 9.95
+	Hs
		826945 TCPG_HUMAN (14-540): 0: 572: 33.15		FBW1A_HUMAN (421-593): 2.84e-31: 130: 17.22
+	Hs
		826601 TCPG_HUMAN (14-540): 0: 572: 33.15		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Hs
		903467 TCPH_HUMAN (12-539): 0: 570: 29.64		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Sc
		772899 TCPE_YEAST (3-540): 0: 582: 59.89		MDV1_YEAST (379-508): 4.29e-13: 74.4: 19.46
+	Hs
		826772 TCPG_HUMAN (14-540): 0: 572: 33.15		POC1A_HUMAN (71-262): 1.3e-15: 81.1: 9.95