Protein: TCPZ
T-complex protein 1 subunit zeta (TCP-1-zeta) (CCT-zeta)

Gene: TCPZ, CCT6
Organism: Saccharomyces cerevisiae S288C
Interactions: 239
UniProt ID: P39079

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005832 - chaperonin-containing T-complex
GO:0006457 - protein folding
GO:0016887 - ATP hydrolysis activity
GO:0051082 - unfolded protein binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

810801

TCPG
T-complex protein 1 subunit gamma

5

19

Small-scale

0.898

High

810940

TCPD
T-complex protein 1 subunit delta

4

19

High-throughput

0.875

High

553996

TCPA
T-complex protein 1 subunit alpha

3

18

Small-scale

0.827

High

811107

TCPH
T-complex protein 1 subunit eta

2

19

High-throughput

0.789

High

811134

2ABA
Protein phosphatase PP2A regulatory subunit B

3

20

High-throughput

0.770

High

810685

TCPB
T-complex protein 1 subunit beta

2

19

High-throughput

0.754

High

811100

TCPE
T-complex protein 1 subunit epsilon

2

16

High-throughput

0.754

High

486463

TBA3
Tubulin alpha-3 chain

2

20

High-throughput

0.705

High

781874

CAF4
CCR4-associated factor 4

2

20

High-throughput

0.705

High

754281

DCA13
Protein SOF1

2

20

High-throughput

0.694

High

811200

CMR1
DNA damage-binding protein CMR1

2

20

High-throughput

0.675

High

670716

SIS1
Protein SIS1

3

2

High-throughput

0.633

High

617395

GBB
Guanine nucleotide-binding protein subunit beta

1

20

High-throughput

0.618

High

637221

PWP1
Periodic tryptophan protein 1

1

20

High-throughput

0.618

High

793922

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

20

High-throughput

0.618

High

811089

PEX7
Peroxisomal targeting signal 2 receptor

1

20

High-throughput

0.618

High

811094

UTP7
U3 small nucleolar RNA-associated protein 7

1

20

High-throughput

0.618

High

811105

COPB2
Coatomer subunit beta'

1

17

High-throughput

0.618

High

811106

PFS2
Polyadenylation factor subunit 2

1

20

High-throughput

0.618

High

811151

WDR59
Maintenance of telomere capping protein 5

1

20

High-throughput

0.618

High

811162

ERB1
Ribosome biogenesis protein ERB1

1

20

High-throughput

0.618

High

811189

RAD28
Radiation-sensitive protein 28

1

20

High-throughput

0.618

High

811194

WTM2
Transcriptional modulator WTM2

1

1

High-throughput

0.618

High

811199

PRP46
Pre-mRNA-splicing factor PRP46

1

20

High-throughput

0.618

High

811115

TCPQ
T-complex protein 1 subunit theta

1

19

High-throughput

0.618

High

811133

ACT
Actin

1

20

High-throughput

0.618

High

811156

PLP1
Phosducin-like protein 1

1

16

High-throughput

0.618

High

811188

PLP2
Phosducin-like protein 2

2

17

High-throughput

0.611

High

633469

PP11
Serine/threonine-protein phosphatase PP1-1

3

20

High-throughput

0.609

High

392740

HSP82
ATP-dependent molecular chaperone HSP82

2

9

High-throughput

0.584

High

579403

HSC82
ATP-dependent molecular chaperone HSC82

2

9

High-throughput

0.584

High

760532

FAB1
1-phosphatidylinositol 3-phosphate 5-kinase FAB1

1

19

High-throughput

0.575

High

523970

HSP71
Heat shock protein SSA1

2

5

High-throughput

0.571

High

526711

HSP72
Heat shock protein SSA2

2

5

High-throughput

0.571

High

544896

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.571

High

811097

SSB2
Ribosome-associated molecular chaperone SSB2

2

5

High-throughput

0.571

High

811139

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

2

3

High-throughput

0.558

High

811197

WTM1
Transcriptional modulator WTM1

2

1

High-throughput

0.558

High

486180

TBA1
Tubulin alpha-1 chain

1

20

High-throughput

0.553

High

802065

ARP1
Centractin

1

20

High-throughput

0.553

High

808370

SEC31
Protein transport protein SEC31

1

20

High-throughput

0.553

High

811114

MDV1
Mitochondrial division protein 1

1

20

High-throughput

0.553

High

811159

TAP42
Type 2A phosphatase-associated protein 42

2

9

High-throughput

0.537

High

802861

DBP8
ATP-dependent RNA helicase DBP8

1

2

High-throughput

0.536

High

734102

EF2
Elongation factor 2

2

5

High-throughput

0.533

High

359230

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

2

2

High-throughput

0.521

High

367754

ENO1
Enolase 1

2

1

High-throughput

0.521

High

367969

ENO2
Enolase 2

2

1

High-throughput

0.521

High

430852

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

2

2

High-throughput

0.521

High

672241

CDC10
Cell division control protein 10

2

7

High-throughput

0.521

High

811124

HOS2
Probable histone deacetylase HOS2

2

20

High-throughput

0.521

High

811167

UTP13
U3 small nucleolar RNA-associated protein 13

1

20

High-throughput

0.514

High

811190

YTM1
Ribosome biogenesis protein YTM1

1

20

High-throughput

0.514

High

440845

KIN28
Serine/threonine-protein kinase KIN28

1

17

High-throughput

0.501

High

448726

SNF1
Carbon catabolite-derepressing protein kinase

1

2

High-throughput

0.501

High

470134

SPS1
Sporulation-specific protein 1

1

20

High-throughput

0.501

High

656468

KC11
Casein kinase I homolog 1

1

7

High-throughput

0.501

High

793153

AKL1
Serine/threonine-protein kinase AKL1

1

4

High-throughput

0.501

High

801828

KSP1
Serine/threonine-protein kinase KSP1

1

13

High-throughput

0.501

High

811123

SCY1
Protein kinase-like protein SCY1

1

6

High-throughput

0.501

High

811148

PKH3
Serine/threonine-protein kinase PKH3

1

20

High-throughput

0.501

High

811155

CTK1
CTD kinase subunit alpha

1

20

High-throughput

0.501

High

811193

YP150
Putative serine/threonine-protein kinase YPL150W

1

7

High-throughput

0.501

High

811195

PKH2
Serine/threonine-protein kinase PKH2

1

20

High-throughput

0.501

High

684621

CDC20
APC/C activator protein CDC20

1

20

High-throughput

0.489

High

811091

FHP
Flavohemoprotein

1

8

High-throughput

0.489

High

811128

BRE5
UBP3-associated protein BRE5

1

5

High-throughput

0.489

High

592260

VATB
V-type proton ATPase subunit B

1

8

High-throughput

0.479

High

603471

VATA
V-type proton ATPase catalytic subunit A

1

12

High-throughput

0.479

High

679688

CDC48
Cell division control protein 48

1

7

High-throughput

0.479

High

741591

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.479

High

760586

TSA1
Peroxiredoxin TSA1

1

7

High-throughput

0.479

High

811132

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.479

High

811196

GIN4
Serine/threonine-protein kinase GIN4

1

7

High-throughput

0.479

High

811198

DBP10
ATP-dependent RNA helicase DBP10

1

3

High-throughput

0.479

High

365625

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.458

High

646405

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.458

High

780020

EAP1
Protein EAP1

1

0

High-throughput

0.458

High

811118

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.458

High

811154

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.458

High

811158

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.458

High

811160

UTP14
U3 small nucleolar RNA-associated protein 14

1

0

High-throughput

0.458

High

811141

UBC7
Ubiquitin-conjugating enzyme E2 7

1

6

High-throughput

0.457

High

739870

RPD3
Histone deacetylase RPD3

1

20

Small-scale

0.457

High

367025

ATPB
ATP synthase subunit beta, mitochondrial

1

8

High-throughput

0.445

High

574799

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

1

6

High-throughput

0.445

High

632675

DBP4
ATP-dependent RNA helicase HCA4

1

2

High-throughput

0.445

High

649494

UBA1
Ubiquitin-activating enzyme E1 1

1

2

High-throughput

0.445

High

671489

RAD57
DNA repair protein RAD57

1

3

High-throughput

0.445

High

671957

HAL4
Serine/threonine-protein kinase HAL4/SAT4

1

12

High-throughput

0.445

High

743092

STH1
Nuclear protein STH1/NPS1

1

1

High-throughput

0.445

High

811120

CTF18
Chromosome transmission fidelity protein 18

1

8

High-throughput

0.445

High

811122

UBC11
Ubiquitin-conjugating enzyme E2-18 kDa

1

4

High-throughput

0.445

High

811138

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

17

High-throughput

0.445

High

811143

NACB1
Nascent polypeptide-associated complex subunit beta-1

1

1

High-throughput

0.445

High

811170

DBP9
ATP-dependent RNA helicase DBP9

1

2

High-throughput

0.445

High

149767

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.437

High

402006

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

4

High-throughput

0.437

High

427282

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.437

High

577301

NSP1
Nucleoporin NSP1

1

2

High-throughput

0.437

High

634236

NUP1
Nucleoporin NUP1

1

3

High-throughput

0.437

High

647115

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.437

High

660793

PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

1

20

High-throughput

0.437

High

677400

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.437

High

736978

CDC3
Cell division control protein 3

1

1

High-throughput

0.437

High

737317

CDC12
Cell division control protein 12

1

1

High-throughput

0.437

High

738470

NUP2
Nucleoporin NUP2

1

2

High-throughput

0.437

High

747016

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

2

High-throughput

0.437

High

776577

DEF1
RNA polymerase II degradation factor 1

1

1

High-throughput

0.437

High

779233

CENPA
Histone H3-like centromeric protein CSE4

1

3

High-throughput

0.437

High

794131

GLU2A
Glucosidase 2 subunit alpha

1

4

High-throughput

0.437

High

794874

MAP2
Methionine aminopeptidase 2

1

4

High-throughput

0.437

High

803542

RPN1
26S proteasome regulatory subunit RPN1

1

3

High-throughput

0.437

High

805543

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

20

Small-scale

0.437

High

811099

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

20

High-throughput

0.437

High

811111

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

7

High-throughput

0.437

High

811147

TOM1
E3 ubiquitin-protein ligase TOM1

1

13

High-throughput

0.437

High

811161

POB3
FACT complex subunit POB3

1

1

High-throughput

0.437

High

811163

YMW4
Uncharacterized protein YMR074C

1

5

High-throughput

0.437

High

811180

SHS1
Seventh homolog of septin 1

1

9

High-throughput

0.437

High

811187

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

712920

PAP
Poly(A) polymerase

1

0

High-throughput

0.426

High

752266

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.426

High

811131

NSG2
Protein NSG2

1

0

High-throughput

0.426

High

811137

ARG56
Protein ARG5,6, mitochondrial [Cleaved into: N-acetyl-gamma-glutamyl-phosphate reductase

1

0

High-throughput

0.426

High

811144

CWC27
Peptidyl-prolyl isomerase CWC27

1

0

High-throughput

0.426

High

394568

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.407

High

419427

H2A1
Histone H2A.1

1

1

High-throughput

0.407

High

448496

RAD7
DNA repair protein RAD7

1

3

High-throughput

0.407

High

452024

TOM70
Mitochondrial import receptor subunit TOM70

1

11

High-throughput

0.407

High

671415

RNA14
mRNA 3'-end-processing protein RNA14

1

2

High-throughput

0.407

High

676928

SRO9
RNA-binding protein SRO9

1

6

High-throughput

0.407

High

734856

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

20

High-throughput

0.407

High

736850

APE2
Aminopeptidase 2, mitochondrial

1

4

High-throughput

0.407

High

740162

RPN2
26S proteasome regulatory subunit RPN2

1

3

High-throughput

0.407

High

811095

TSC11
Target of rapamycin complex 2 subunit TSC11

1

4

High-throughput

0.407

High

811096

MGDP1
Putative magnesium-dependent phosphatase YER134C

1

1

High-throughput

0.407

High

811101

TM108
Protein TMA108

1

4

High-throughput

0.407

High

811121

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

4

High-throughput

0.407

High

811127

DUS2
tRNA-dihydrouridine(20) synthase [NAD(P)+]

1

2

High-throughput

0.407

High

811130

TDA7
Topoisomerase I damage affected protein 7

1

5

High-throughput

0.407

High

811140

NOP3
Serine/arginine

1

1

High-throughput

0.407

High

811145

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.407

High

811146

GDE1
Glycerophosphocholine phosphodiesterase GDE1

1

5

High-throughput

0.407

High

811150

PRP42
U1 small nuclear ribonucleoprotein component PRP42

1

3

High-throughput

0.407

High

811157

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

1

High-throughput

0.407

High

811164

RCO1
Transcriptional regulatory protein RCO1

1

5

High-throughput

0.407

High

811168

DUS4
tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]

1

2

High-throughput

0.407

High

811169

IMB1
Importin subunit beta-1

1

1

High-throughput

0.407

High

811176

SSK1
Osmolarity two-component system protein SSK1

1

1

High-throughput

0.407

High

811177

BDF2
Bromodomain-containing factor 2

1

6

High-throughput

0.407

High

811191

HOSM
Homocitrate synthase, mitochondrial

1

4

High-throughput

0.407

High

811202

HUB1
Ubiquitin-like modifier HUB1

1

1

High-throughput

0.407

High

811098

VID27
Vacuolar import and degradation protein 27

3

0

High-throughput

0.342

High

811116

HGH1
Protein HGH1

3

0

Small-scale

0.342

High

811113

STU2
Protein STU2

2

0

High-throughput

0.319

High

726216

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

2

0

High-throughput

0.313

High

435097

RS3
Small ribosomal subunit protein uS3

2

0

High-throughput

0.305

High

811102

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.305

High

806709

RPN10
26S proteasome regulatory subunit RPN10

2

0

High-throughput

0.298

High

779408

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.279

Low

807220

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.279

Low

518020

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.261

Low

432584

RL7A
Large ribosomal subunit protein uL30A

1

0

High-throughput

0.249

Low

435969

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

513013

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

513366

RL23B
Large ribosomal subunit protein uL14B

1

0

High-throughput

0.249

Low

558723

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

570018

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.249

Low

638801

REB1
DNA-binding protein REB1

1

0

High-throughput

0.249

Low

674629

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

707115

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

723181

ATP7
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.249

Low

734984

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

747855

SMY2
Protein SMY2

1

0

High-throughput

0.249

Low

753373

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

763891

SPT10
Protein SPT10

1

0

High-throughput

0.249

Low

802823

GRE3
NADPH-dependent aldose reductase GRE3

1

0

High-throughput

0.249

Low

811090

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

811104

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.249

Low

811108

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

811112

MHP1
MAP-homologous protein 1

1

0

High-throughput

0.249

Low

811117

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

811125

PIB2
Glutamine sensor PIB2

1

0

High-throughput

0.249

Low

811135

REG1
Resistance to glucose repression protein 1

1

0

High-throughput

0.249

Low

811149

BUL2
Ubiquitin ligase-binding protein BUL2

1

0

Small-scale

0.249

Low

811153

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.249

Low

811171

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

811178

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

811184

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

150094

YA11B
Truncated transposon Ty1-A Gag-Pol polyprotein

1

0

High-throughput

0.232

Low

366800

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.232

Low

434570

RL22A
Large ribosomal subunit protein eL22A

1

0

High-throughput

0.232

Low

439339

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.232

Low

550054

RAP1
DNA-binding protein RAP1

1

0

High-throughput

0.232

Low

577131

SEC63
Protein translocation protein SEC63

1

0

High-throughput

0.232

Low

600687

SEC2
Rab guanine nucleotide exchange factor SEC2

1

0

High-throughput

0.232

Low

645822

VATE
V-type proton ATPase subunit E

1

0

High-throughput

0.232

Low

657186

GYS1
Glycogen [starch] synthase isoform 1

1

0

High-throughput

0.232

Low

672308

RV161
Reduced viability upon starvation protein 161

1

0

High-throughput

0.232

Low

715418

MPI
Mannose-6-phosphate isomerase

1

0

High-throughput

0.232

Low

721941

XPO1
Exportin-1

1

0

High-throughput

0.232

Low

740409

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.232

Low

748288

SPT4
Transcription elongation factor SPT4

1

0

High-throughput

0.232

Low

780371

ELF1
Transcription elongation factor 1

1

0

High-throughput

0.232

Low

780602

CAB3
Coenzyme A biosynthesis protein 3

1

0

High-throughput

0.232

Low

796218

RKM3
Ribosomal lysine N-methyltransferase 3

1

0

High-throughput

0.232

Low

796415

TRM7
tRNA

1

0

High-throughput

0.232

Low

796745

RXT2
Transcriptional regulatory protein RXT2

1

0

High-throughput

0.232

Low

798194

DPH7
Diphthine methyltransferase

1

0

High-throughput

0.232

Low

803823

BCD1
Box C/D snoRNA protein 1

1

0

High-throughput

0.232

Low

805374

DNPEP
Aspartyl aminopeptidase 4

1

0

High-throughput

0.232

Low

807072

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.232

Low

811092

DPO5
rDNA transcriptional regulator POL5

1

0

High-throughput

0.232

Low

811093

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

0

High-throughput

0.232

Low

811103

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

0

High-throughput

0.232

Low

811109

SWP82
SWI/SNF global transcription activator complex subunit SWP82

1

0

High-throughput

0.232

Low

811110

BLM10
Proteasome activator BLM10

1

0

High-throughput

0.232

Low

811119

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.232

Low

811126

CWC22
Pre-mRNA-splicing factor CWC22

1

0

High-throughput

0.232

Low

811129

ESF2
Pre-rRNA-processing protein ESF2

1

0

High-throughput

0.232

Low

811136

STP1
Transcription factor STP1

1

0

High-throughput

0.232

Low

811142

MEC3
DNA damage checkpoint control protein MEC3

1

0

High-throughput

0.232

Low

811152

VPS61
Putative uncharacterized protein VPS61

1

0

High-throughput

0.232

Low

811165

YM91
Putative methyltransferase YMR310C

1

0

High-throughput

0.232

Low

811166

ERP1
Protein ERP1

1

0

High-throughput

0.232

Low

811172

NOC4
Nucleolar complex protein 4

1

0

High-throughput

0.232

Low

811173

SWC7
SWR1-complex protein 7

1

0

High-throughput

0.232

Low

811174

VAC14
Vacuole morphology and inheritance protein 14

1

0

High-throughput

0.232

Low

811175

MDM36
Mitochondrial distribution and morphology protein 36

1

0

High-throughput

0.232

Low

811179

ACK1
Activator of C kinase protein 1

1

0

High-throughput

0.232

Low

811181

YL032
KH domain-containing protein YLL032C

1

0

High-throughput

0.232

Low

811182

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.232

Low

811183

RRP44
Exosome complex exonuclease DIS3

1

0

High-throughput

0.232

Low

811185

PUS7
Multisubstrate pseudouridine synthase 7

1

0

High-throughput

0.232

Low

811186

RDL2
Thiosulfate sulfurtransferase RDL2, mitochondrial

1

0

High-throughput

0.232

Low

811192

NMD4
Nonsense-mediated decay protein 4

1

0

High-throughput

0.232

Low

811201

SET6
Potential protein lysine methyltransferase SET6

1

0

High-throughput

0.232

Low

811203

SAS5
Something about silencing protein 5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025