HitPredict

Interactor 1: VHL (P40338)
von Hippel-Lindau disease tumor suppressor (pVHL)
Gene: VHL

Interactor 2: KPCZ (Q02956)
Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)
Gene: Prkcz

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17101696
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~VHL
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 181 Mm			1 592
+	Hs
		822628 VHL_HUMAN (2-179): 1.76e-113: 323: 80.42		KPCZ_HUMAN (1-592): 0: 657: 95.61
+	Hs
		822500 VHL_HUMAN (2-179): 1.76e-113: 323: 80.42		KPCI_HUMAN (1-592): 0: 645: 69.37
+	Hs
		822629 VHL_HUMAN (2-179): 1.76e-113: 323: 80.42		KPCD_HUMAN (10-586): 4.98e-175: 513: 31.51
+	Mm
		728509 VHL_MOUSE (1-181): 1.1e-120: 340: 100.00		AKT1_MOUSE (143-582): 6.02e-150: 442: 35.73
+	Hs
		728556 VHL_HUMAN (2-179): 1.76e-113: 323: 80.42		AKT2_HUMAN (167-582): 1.26e-150: 443: 37.41
+	Hs
		728077 VHL_HUMAN (2-179): 1.76e-113: 323: 80.42		AKT1_HUMAN (143-582): 1.01e-149: 441: 35.96
+	Hs
		666229 VHL_HUMAN (2-179): 1.76e-113: 323: 80.42		KPCL_HUMAN (6-185): 2.01e-30: 128: 24.08