HitPredict

Interactor 1: PAXI (P49023)
Paxillin
Gene: PXN

Interactor 2: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	24935154, 14665621
Identification Methods	phosphatase assay, anti bait coimmunoprecipitation
Interaction Type	dephosphorylation reaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 591 Hs			1 593
+	Hs
		616910 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		PTPRB_HUMAN (147-555): 2.35e-115: 379: 27.91
+	Hs
		665886 FHL3_HUMAN (382-590): 1.13e-57: 196: 28.64		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		823378 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		PTPRJ_HUMAN (146-528): 1.52e-109: 359: 30.55
+	Hs
		441191 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		PTPRC_HUMAN (33-579): 2.25e-85: 291: 18.29
+	Hs
		823400 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		PTPRK_HUMAN (36-524): 5.17e-72: 254: 18.94
+	Hs
		146924 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		PTPRT_HUMAN (35-524): 6.59e-70: 247: 18.90
+	Hs
		617161 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		PTPRZ_HUMAN (33-537): 1.15e-65: 235: 16.73
+	Hs
		617089 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		PTPRG_HUMAN (33-527): 9.52e-62: 223: 17.05
+	Hs
		150522 ABLM1_HUMAN (512-590): 6.08e-10: 64.4: 25.32		PTPRD_HUMAN (39-522): 2.1e-115: 379: 26.76
+	Hs
		563782 ZNF3_HUMAN (506-591): 3.89e-16: 83: 16.84		PTPRK_HUMAN (36-524): 5.17e-72: 254: 18.94