HitPredict

Interactor 1: ARRB1 (P49407)
Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2)
Gene: ARRB1

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

The method score is based on:

Property	Details
Experiments	17947233, 18544533
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006511 - ubiquitin-dependent protein catabolic process and 5 others more... GO:0016567 - protein ubiquitination GO:0031410 - cytoplasmic vesicle GO:0032088 - negative regulation of NF-kappaB transcription factor activity GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:1990763 - arrestin family protein binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	418
Hs

1	903

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024