Protein: PTN18
Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase)

Gene: PTN18, PTPN18
Organism: Homo sapiens
Interactions: 58
UniProt ID: Q99952

Gene Ontology (top 5):
GO:0001825 - blastocyst formation
GO:0004725 - protein tyrosine phosphatase activity
GO:0004726 - non-membrane spanning protein tyrosine phosphatase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

363775

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.843

High

411020

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.761

High

1408280

PPIP2
Proline-serine-threonine phosphatase-interacting protein 2

4

14

High-throughput

0.694

High

987897

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.691

High

220799

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

3

15

Small-scale

0.682

High

1251948

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.625

High

1408271

PTN18
Tyrosine-protein phosphatase non-receptor type 18

1

19

High-throughput

0.618

High

124831

AIP
AH receptor-interacting protein

2

3

High-throughput

0.611

High

1408284

BAG5
BAG family molecular chaperone regulator 5

2

0

High-throughput

0.602

High

731568

STIP1
Stress-induced-phosphoprotein 1

2

4

High-throughput

0.584

High

164871

SH21B
SH2 domain-containing protein 1B

1

20

Small-scale

0.575

High

840981

ABL2
Tyrosine-protein kinase ABL2

1

20

Small-scale

0.575

High

160592

IRS4
Insulin receptor substrate 4

1

7

High-throughput

0.536

High

259069

DNJA2
DnaJ homolog subfamily A member 2

1

2

High-throughput

0.536

High

291513

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.536

High

348686

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.536

High

537788

HSP7C
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.536

High

679245

DNJB1
DnaJ homolog subfamily B member 1

1

2

High-throughput

0.536

High

1118570

TBB2A
Tubulin beta-2A chain

1

4

High-throughput

0.536

High

1207008

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

1

High-throughput

0.536

High

1401313

PASK
PAS domain-containing serine/threonine-protein kinase

1

9

High-throughput

0.536

High

1405834

DNJC7
DnaJ homolog subfamily C member 7

1

5

High-throughput

0.536

High

1406470

ATX2
Ataxin-2

1

1

High-throughput

0.536

High

1408273

CAB45
45 kDa calcium-binding protein

1

6

High-throughput

0.536

High

1408274

TBB6
Tubulin beta-6 chain

1

4

High-throughput

0.536

High

1408276

TRIM7
E3 ubiquitin-protein ligase TRIM7

1

2

High-throughput

0.536

High

1408282

WRP73
WD repeat-containing protein WRAP73

1

1

High-throughput

0.536

High

1408285

CHIP
E3 ubiquitin-protein ligase CHIP

1

3

High-throughput

0.536

High

1408286

FBW1A
F-box/WD repeat-containing protein 1A

1

4

Small-scale

0.515

High

289885

TIPRL
TIP41-like protein

1

0

High-throughput

0.513

High

347281

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

1092711

AF1Q
Protein AF1q

1

0

High-throughput

0.513

High

1131703

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

0

High-throughput

0.513

High

680481

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

2

High-throughput

0.489

High

1408283

STML2
Stomatin-like protein 2, mitochondrial

1

6

High-throughput

0.489

High

791662

SYUA
Alpha-synuclein

1

1

High-throughput

0.481

High

532898

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.479

High

613161

EGR1
Early growth response protein 1

1

4

Small-scale

0.479

High

827253

ARL1
ADP-ribosylation factor-like protein 1

1

8

High-throughput

0.479

High

1014954

ARF1
ADP-ribosylation factor 1

1

5

High-throughput

0.479

High

1307353

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

1

High-throughput

0.479

High

1408272

LZTS2
Leucine zipper putative tumor suppressor 2

1

8

High-throughput

0.479

High

1408281

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

4

High-throughput

0.479

High

441503

AGAL
Alpha-galactosidase A

1

0

High-throughput

0.458

High

1380308

CNKR1
Connector enhancer of kinase suppressor of ras 1

1

13

Small-scale

0.457

High

124463

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.437

High

162268

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

1

High-throughput

0.437

High

726290

SSR4
Somatostatin receptor type 4

1

11

High-throughput

0.437

High

1312329

MIRO1
Mitochondrial Rho GTPase 1

1

20

High-throughput

0.437

High

1359181

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

2

High-throughput

0.437

High

1395104

TMX3
Protein disulfide-isomerase TMX3

1

9

High-throughput

0.437

High

1408278

CPVL
Probable serine carboxypeptidase CPVL

1

1

High-throughput

0.437

High

1408275

SYTM
Threonine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

1408277

TNG6
Transport and Golgi organization protein 6 homolog

1

0

High-throughput

0.279

Low

283944

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.249

Low

460868

CATB
Cathepsin B

1

0

High-throughput

0.249

Low

1408279

MFSD1
Lysosomal dipeptide transporter MFSD1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025