Interactor 1: CENPA (P49450)
Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
Gene: CENPA

Interactor 2: H4 (P62805)
Histone H4
Gene: H4C1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.965

The method score is based on:

Property Details
Experiments 34079125, 15009096, 20080577, 16622419, 24530302, 20739937, 26167883, 19410544, 21478274
Identification Methods proximity labelling technology, biochemical, affinity chromatography technology, x-ray crystallography, x ray scattering, molecular sieving, tandem affinity purification
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains CENP-T_C~Histone
Common GO terms GO:0000786 - nucleosome
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0030527 - structural constituent of chromatin
and 3 others

more...

Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 140
Hs

1 103
+ Hs
+ Mm
+ Hs
+ Hs
+ Ce
+ Xl
+ Xl
+ Hs
+ Hs
+ Mm
+ Mm
+ Ce
+ Sp
+ Hs
+ Kl
+ Sc
+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024