Protein: SCNNB
Epithelial sodium channel subunit beta (Beta-ENaC) (ENaC subunit beta) (ENaCB) (Epithelial Na(+) channel subunit beta) (Amiloride-sensitive sodium channel subunit beta) (Beta-NaCH) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB)

Gene: SCNNB, SCNN1B
Organism: Homo sapiens
Interactions: 23
UniProt ID: P51168

Gene Ontology (top 5):
GO:0002269 - leukocyte activation involved in inflammatory response
GO:0002283 - neutrophil activation involved in immune response
GO:0003014 - renal system process
GO:0005886 - plasma membrane
GO:0006883 - intracellular sodium ion homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

788519

SCNNA
Epithelial sodium channel subunit alpha

3

12

Small-scale

0.854

High

861521

NEDD4
E3 ubiquitin-protein ligase NEDD4

9

20

Small-scale

0.755

High

902326

NED4L
E3 ubiquitin-protein ligase NEDD4-like

9

20

Small-scale

0.745

High

902320

SCNNG
Epithelial sodium channel subunit gamma

1

13

Small-scale

0.621

High

131833

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

20

Small-scale

0.602

High

902330

EPN1
Epsin-1

1

2

Small-scale

0.561

High

902319

SCNNB
Epithelial sodium channel subunit beta

1

13

Small-scale

0.552

High

902324

COMD1
COMM domain-containing protein 1

2

2

Small-scale

0.549

High

902332

SERP1
Stress-associated endoplasmic reticulum protein 1

1

2

Small-scale

0.504

High

902325

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

20

Small-scale

0.501

High

902328

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.501

High

169478

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

1

Small-scale

0.479

High

400505

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

Small-scale

0.479

High

828186

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

6

Small-scale

0.479

High

902322

STX1A
Syntaxin-1A

1

3

Small-scale

0.479

High

902331

AP1M2
AP-1 complex subunit mu-2

1

2

Small-scale

0.479

High

122936

SGK1
Serine/threonine-protein kinase Sgk1

1

0

Small-scale

0.458

High

902323

HECW1
E3 ubiquitin-protein ligase HECW1

1

20

Small-scale

0.457

High

902329

COMDA
COMM domain-containing protein 10

1

4

Small-scale

0.457

High

288374

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

6

Small-scale

0.437

High

902321

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.437

High

902327

T22D3
TSC22 domain family protein 3

1

2

Small-scale

0.437

High


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Last updated: 11Aug2025