Protein: SCNNA
Epithelial sodium channel subunit alpha (Alpha-ENaC) (ENaC subunit alpha) (ENaCA) (Epithelial Na(+) channel subunit alpha) (Alpha-NaCH) (Amiloride-sensitive sodium channel subunit alpha) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA) (Sodium channel epithelial 1 subunit alpha)

Gene: SCNNA, SCNN1A
Organism: Homo sapiens
Interactions: 66
UniProt ID: P37088

Gene Ontology (top 5):
GO:0001669 - acrosomal vesicle
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006883 - intracellular sodium ion homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

788519

SCNNB
Epithelial sodium channel subunit beta

3

12

Small-scale

0.854

High

788520

SCNNG
Epithelial sodium channel subunit gamma

3

12

Small-scale

0.827

High

788518

NEDD4
E3 ubiquitin-protein ligase NEDD4

7

20

Small-scale

0.752

High

788541

NED4L
E3 ubiquitin-protein ligase NEDD4-like

10

20

Small-scale

0.747

High

788539

ASIC4
Acid-sensing ion channel 4

1

12

High-throughput

0.691

High

788553

BTNL2
Butyrophilin-like protein 2

1

1

High-throughput

0.691

High

168385

NCTR3
Natural cytotoxicity triggering receptor 3

1

0

High-throughput

0.656

High

788521

SCNND
Epithelial sodium channel subunit delta

1

12

Small-scale

0.618

High

788525

ASIC1
Acid-sensing ion channel 1

1

12

Small-scale

0.618

High

288362

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

6

Small-scale

0.584

High

788558

EPN1
Epsin-1

1

2

Small-scale

0.561

High

788516

SCNNA
Epithelial sodium channel subunit alpha

1

12

Small-scale

0.552

High

380266

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

12

High-throughput

0.536

High

380409

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

14

High-throughput

0.536

High

388116

ACHA
Acetylcholine receptor subunit alpha

1

1

High-throughput

0.536

High

409562

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

14

High-throughput

0.536

High

438873

CD1A
T-cell surface glycoprotein CD1a

1

10

High-throughput

0.536

High

553421

FCERA
High affinity immunoglobulin epsilon receptor subunit alpha

1

1

High-throughput

0.536

High

575639

GPIX
Platelet glycoprotein IX

1

1

High-throughput

0.536

High

593296

PGFRA
Platelet-derived growth factor receptor alpha

1

1

High-throughput

0.536

High

607350

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

8

High-throughput

0.536

High

788526

NRG1
Pro-neuregulin-1, membrane-bound isoform

1

1

High-throughput

0.536

High

788527

ACHD
Acetylcholine receptor subunit delta

1

1

High-throughput

0.536

High

788529

PON2
Serum paraoxonase/arylesterase 2

1

5

High-throughput

0.536

High

788536

CLC4C
C-type lectin domain family 4 member C

1

3

High-throughput

0.536

High

788538

T106A
Transmembrane protein 106A

1

2

High-throughput

0.536

High

788542

TSN18
Tetraspanin-18

1

1

High-throughput

0.536

High

788546

CST11
Cystatin-11

1

1

High-throughput

0.536

High

788551

DNJB9
DnaJ homolog subfamily B member 9

1

2

High-throughput

0.536

High

788552

CLC2D
C-type lectin domain family 2 member D

1

3

High-throughput

0.536

High

788554

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

1

1

High-throughput

0.536

High

788555

CLC4E
C-type lectin domain family 4 member E

1

3

High-throughput

0.536

High

341291

ECEL1
Endothelin-converting enzyme-like 1

1

0

High-throughput

0.513

High

460247

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

0

High-throughput

0.513

High

624192

FUT1
Galactoside alpha-(1,2)-fucosyltransferase 1

1

0

High-throughput

0.513

High

788522

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.513

High

788537

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.513

High

788550

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.513

High

131774

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

20

Small-scale

0.501

High

788533

HECW1
E3 ubiquitin-protein ligase HECW1

1

20

Small-scale

0.501

High

788540

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

20

Small-scale

0.501

High

788557

COMDA
COMM domain-containing protein 10

1

4

Small-scale

0.501

High

337164

APOM
Apolipoprotein M

1

1

High-throughput

0.489

High

547979

PSPC
Surfactant protein C

1

1

High-throughput

0.489

High

788532

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

1

High-throughput

0.489

High

788547

CST9L
Cystatin-9-like

1

1

High-throughput

0.489

High

788549

SDF2L
Stromal cell-derived factor 2-like protein 1

1

3

High-throughput

0.489

High

788543

TS101
Tumor susceptibility gene 101 protein

1

1

Small-scale

0.481

High

788545

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

20

Small-scale

0.481

High

788560

SERP1
Stress-associated endoplasmic reticulum protein 1

1

2

Small-scale

0.481

High

788524

CSK21
Casein kinase II subunit alpha

1

0

Small-scale

0.480

High

169466

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

1

Small-scale

0.479

High

788517

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

6

Small-scale

0.479

High

788528

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

6

Small-scale

0.479

High

788530

STX1A
Syntaxin-1A

1

3

Small-scale

0.479

High

788534

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

20

Small-scale

0.479

High

788556

HYOU1
Hypoxia up-regulated protein 1

1

1

Small-scale

0.479

High

788559

AP1M2
AP-1 complex subunit mu-2

1

2

Small-scale

0.479

High

788523

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.460

High

249578

SNX3
Sorting nexin-3

1

0

Small-scale

0.458

High

380525

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

12

High-throughput

0.445

High

788544

DERL1
Derlin-1

1

1

Small-scale

0.437

High

788531

TAZ
Tafazzin

1

0

High-throughput

0.279

Low

788535

SIGL1
SIGLEC family-like protein 1

1

0

High-throughput

0.279

Low

788548

UD17
UDP-glucuronosyltransferase 1A7

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025