HitPredict

Interactor 1: NU145 (P49687)
Nucleoporin NUP145 (EC 3.4.21.-) (Nuclear pore protein NUP145) [Cleaved into: Nucleoporin NUP145N (N-NUP145); Nucleoporin NUP145C (C-NUP145)]
Gene: NUP145

Interactor 2: SEH1 (P53011)
Nucleoporin SEH1 (Nuclear pore protein SEH1) (SEC13 homolog 1)
Gene: SEH1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.977

Property	Details
Experiments	10747086, 11805837, 20512149, 9305650, 16554755, 16429126, 15741174, 18046452, 18046405, 10617624, 21454883
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Nup96~WD40
Common GO terms	GO:0005643 - nuclear pore GO:0017056 - structural constituent of nuclear pore GO:0031080 - nuclear pore outer ring GO:0031965 - nuclear membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1317 Sc			1 349
+	Sc
		830680 NU145_YEAST (1-1317): 0: 1125: 100.00		SEC13_YEAST (1-346): 5.48e-68: 217: 21.51
+	Hs
		979963 IF4G1_HUMAN (3-740): 5.58e-52: 203: 7.92		FBXW7_HUMAN (3-285): 2.49e-55: 193: 13.24
+	Hs
		903152 IF4G1_HUMAN (3-740): 5.58e-52: 203: 7.92		WDR5_HUMAN (149-345): 9.8e-50: 171: 17.26
+	Sp
		292982 NU189_SCHPO (54-501): 1.44e-12: 74.7: 11.74		SEC13_SCHPO (1-346): 1.74e-98: 295: 25.63
+	Sp
		1013470 NU189_SCHPO (54-501): 1.44e-12: 74.7: 11.74		SEH1_SCHPO (2-349): 2.04e-92: 281: 40.52
+	Sc
		858396 NU100_YEAST (45-542): 1.84e-14: 80.8: 14.10		SEH1_YEAST (1-349): 3.91e-85: 262: 100.00
+	Sc
		541905 NSP1_YEAST (3-459): 5.33e-11: 69.3: 13.35		SEH1_YEAST (1-349): 3.91e-85: 262: 100.00
+	Hs
		858034 NUP98_HUMAN (1-435): 2.24e-14: 80.9: 13.29		SEH1_HUMAN (2-347): 1.28e-76: 241: 32.87
+	Hs
		834655 NU153_HUMAN (16-447): 4.54e-11: 70: 10.50		SEH1_HUMAN (2-347): 1.28e-76: 241: 32.87
+	Hs
		727302 NU214_HUMAN (14-341): 6.71e-11: 69.6: 16.43		SEH1_HUMAN (2-347): 1.28e-76: 241: 32.87
+	Hs
		857954 NUP98_HUMAN (1-435): 2.24e-14: 80.9: 13.29		SEC13_HUMAN (1-349): 5.74e-69: 220: 24.45
+	Sc
		971875 NU100_YEAST (45-542): 1.84e-14: 80.8: 14.10		SEC13_YEAST (1-346): 5.48e-68: 217: 21.51
+	Hs
		297852 SC24D_HUMAN (4-257): 1.65e-12: 74.3: 11.97		SEC13_HUMAN (1-349): 5.74e-69: 220: 24.45
+	Hs
		867085 SC24C_HUMAN (2-178): 3.19e-11: 70.1: 12.64		SEC13_HUMAN (1-349): 5.74e-69: 220: 24.45
+	Dm
		1358850 NUP98_DROME (2-690): 2.53e-16: 87: 11.42		WDS_DROME (103-349): 3.1e-57: 191: 15.73
+	Dm
		1370339 Q9VLS7_DROME (2-487): 5.06e-13: 76.2: 11.03		FBXW7_DROME (2-285): 1.6e-52: 188: 13.54
+	Hs
		903374 KMT2C_HUMAN (2-484): 1.69e-14: 81.2: 9.36		WDR5_HUMAN (149-345): 9.8e-50: 171: 17.26
+	Hs
		857957 NUP98_HUMAN (1-435): 2.24e-14: 80.9: 13.29		WDR5_HUMAN (149-345): 9.8e-50: 171: 17.26
+	Mm
		903669 KMT2C_MOUSE (111-546): 9.34e-13: 75.5: 8.48		WDR5_MOUSE (149-345): 9.8e-50: 171: 17.26
+	Hs
		297832 K0754_HUMAN (99-559): 3.22e-26: 119: 7.81		BRWD3_HUMAN (12-137): 2.76e-14: 76.3: 25.40