HitPredict

Interactor 1: CLK2 (P49760)
Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)
Gene: CLK2

Interactor 2: TRA2B (P62995)
Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)
Gene: TRA2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0043484 - regulation of RNA splicing
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 499 Hs			1 288
+	Hs
		833877 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06
+	Hs
		833731 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06
+	Hs
		833706 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00
+	Hs
		834037 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06
+	Hs
		834017 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00
+	Hs
		833874 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		ELAV2_HUMAN (52-244): 6.85e-24: 101: 20.00
+	Hs
		516416 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		PABP1_HUMAN (109-246): 8.28e-22: 96.8: 21.99
+	Hs
		625415 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06
+	Hs
		833880 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		RBM39_HUMAN (15-248): 3.58e-18: 86.1: 21.83
+	Hs
		833736 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		RBM39_HUMAN (15-248): 3.58e-18: 86.1: 21.83
+	Hs
		834030 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		ELAV2_HUMAN (52-244): 6.85e-24: 101: 20.00
+	Hs
		834033 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		PABP4_HUMAN (109-246): 4.69e-22: 97.6: 21.28
+	Hs
		516417 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		PABP1_HUMAN (109-246): 8.28e-22: 96.8: 21.99
+	Hs
		834041 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		RBM39_HUMAN (15-248): 3.58e-18: 86.1: 21.83
+	Hs
		625400 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		ELAV2_HUMAN (52-244): 6.85e-24: 101: 20.00
+	Hs
		1040371 DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20		TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06
+	Hs
		516362 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		PABP1_HUMAN (109-246): 8.28e-22: 96.8: 21.99
+	Dm
		580161 DOA_DROME (8-494): 4.91e-114: 357: 51.83		TRA2_DROME (102-267): 2.45e-25: 103: 44.58
+	Hs
		625424 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		HNRPD_HUMAN (106-178): 6.05e-11: 64: 26.03
+	Hs
		516508 DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50		PABP1_HUMAN (109-246): 8.28e-22: 96.8: 21.99