HitPredict

Interactor 1: CLK3 (P49761)
Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)
Gene: CLK3

Interactor 2: SRSF1 (Q07955)
Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)
Gene: SRSF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.863

Property	Details
Experiments	33961781, 28514442, 34133714
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck GO:0043484 - regulation of RNA splicing
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 638 Hs			1 248
+	Hs
		834031 CLK3_HUMAN (1-638): 0: 542: 100.00		SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48
+	Hs
		834032 CLK3_HUMAN (1-638): 0: 542: 100.00		SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51
+	Hs
		834027 CLK3_HUMAN (1-638): 0: 542: 100.00		SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66
+	Hs
		516417 CLK3_HUMAN (1-638): 0: 542: 100.00		PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67
+	Hs
		834022 CLK3_HUMAN (1-638): 0: 542: 100.00		SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53
+	Hs
		834053 CLK3_HUMAN (1-638): 0: 542: 100.00		SRSF7_HUMAN (14-105): 7.34e-23: 94.8: 40.22
+	Hs
		834033 CLK3_HUMAN (1-638): 0: 542: 100.00		PABP4_HUMAN (118-200): 2.19e-13: 71.2: 16.67
+	Hs
		833727 CLK1_HUMAN (149-625): 1.2e-137: 412: 48.67		SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48
+	Hs
		833728 CLK1_HUMAN (149-625): 1.2e-137: 412: 48.67		SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51
+	Hs
		833875 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51
+	Hs
		833721 CLK1_HUMAN (149-625): 1.2e-137: 412: 48.67		SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66
+	Hs
		833720 CLK1_HUMAN (149-625): 1.2e-137: 412: 48.67		SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00
+	Hs
		833871 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66
+	Hs
		833870 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00
+	Hs
		516362 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67
+	Hs
		516416 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67
+	Hs
		833711 CLK1_HUMAN (149-625): 1.2e-137: 412: 48.67		SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53
+	Hs
		833865 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53
+	Hs
		833742 CLK1_HUMAN (149-625): 1.2e-137: 412: 48.67		SRSF7_HUMAN (14-105): 7.34e-23: 94.8: 40.22
+	Hs
		833887 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		SRSF7_HUMAN (14-105): 7.34e-23: 94.8: 40.22