Protein: MED8
Mediator of RNA polymerase II transcription subunit 8 (Activator-recruited cofactor 32 kDa component) (ARC32) (Mediator complex subunit 8)

Gene: MED8
Organism: Homo sapiens
Interactions: 103
UniProt ID: Q96G25

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

219505

MED7
Mediator of RNA polymerase II transcription subunit 7

5

1

High-throughput

0.932

High

1391333

MED18
Mediator of RNA polymerase II transcription subunit 18

5

1

High-throughput

0.932

High

1391340

MED17
Mediator of RNA polymerase II transcription subunit 17

5

1

High-throughput

0.925

High

1391343

MED11
Mediator of RNA polymerase II transcription subunit 11

5

2

High-throughput

0.919

High

1149700

MED22
Mediator of RNA polymerase II transcription subunit 22

3

1

High-throughput

0.861

High

1391347

MED31
Mediator of RNA polymerase II transcription subunit 31

2

1

High-throughput

0.811

High

287809

MED6
Mediator of RNA polymerase II transcription subunit 6

2

1

High-throughput

0.789

High

192842

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

0

High-throughput

0.770

High

49001

MED19
Mediator of RNA polymerase II transcription subunit 19

10

2

Small-scale

0.758

High

1391332

MED10
Mediator of RNA polymerase II transcription subunit 10

9

1

Small-scale

0.757

High

881584

CDK8
Cyclin-dependent kinase 8

9

3

High-throughput

0.754

High

1391342

MED29
Mediator of RNA polymerase II transcription subunit 29

7

1

Small-scale

0.750

High

1151279

MED1
Mediator of RNA polymerase II transcription subunit 1

6

1

Small-scale

0.733

High

1391334

CDK19
Cyclin-dependent kinase 19

6

3

High-throughput

0.733

High

1391335

MED28
Mediator of RNA polymerase II transcription subunit 28

6

1

Small-scale

0.730

High

1391338

MED4
Mediator of RNA polymerase II transcription subunit 4

5

1

High-throughput

0.718

High

1372175

MED12
Mediator of RNA polymerase II transcription subunit 12

5

2

High-throughput

0.714

High

666885

CCNC
Cyclin-C

5

1

High-throughput

0.706

High

1391337

MED20
Mediator of RNA polymerase II transcription subunit 20

4

2

High-throughput

0.702

High

1391328

MED30
Mediator of RNA polymerase II transcription subunit 30

4

2

Small-scale

0.696

High

1108381

MED21
Mediator of RNA polymerase II transcription subunit 21

5

0

High-throughput

0.690

High

1391341

MED9
Mediator of RNA polymerase II transcription subunit 9

5

0

Small-scale

0.688

High

282408

MED24
Mediator of RNA polymerase II transcription subunit 24

3

1

High-throughput

0.667

High

1391345

MED23
Mediator of RNA polymerase II transcription subunit 23

3

1

High-throughput

0.667

High

1241400

MED27
Mediator of RNA polymerase II transcription subunit 27

3

1

Small-scale

0.656

High

336018

MED26
Mediator of RNA polymerase II transcription subunit 26

3

0

High-throughput

0.638

High

239605

MED14
Mediator of RNA polymerase II transcription subunit 14

2

2

High-throughput

0.611

High

1259057

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

2

2

High-throughput

0.611

High

1391346

MED16
Mediator of RNA polymerase II transcription subunit 16

2

1

High-throughput

0.611

High

188708

BIRC5
Baculoviral IAP repeat-containing protein 5

2

0

High-throughput

0.602

High

1391344

MED13
Mediator of RNA polymerase II transcription subunit 13

2

2

High-throughput

0.601

High

621710

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

High-throughput

0.585

High

667403

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

0

High-throughput

0.585

High

723048

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

0

High-throughput

0.585

High

396702

ESR1
Estrogen receptor

2

5

High-throughput

0.571

High

1147243

ELOB
Elongin-B

1

0

Small-scale

0.568

High

1147099

ELOC
Elongin-C

1

1

Small-scale

0.562

High

1380079

FBXW7
F-box/WD repeat-containing protein 7

2

0

Small-scale

0.559

High

278934

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.518

High

732669

ARRB2
Beta-arrestin-2

1

0

High-throughput

0.518

High

1092303

HSPB3
Heat shock protein beta-3

1

0

High-throughput

0.518

High

409035

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.513

High

621933

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.513

High

681897

RBTN2
Rhombotin-2

1

0

High-throughput

0.513

High

983931

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.513

High

1243763

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

887117

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.505

High

1233206

THOC7
THO complex subunit 7

1

0

Small-scale

0.480

High

1391348

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

Small-scale

0.480

High

283529

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.479

High

372830

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

404321

GCR
Glucocorticoid receptor

1

6

High-throughput

0.479

High

520282

ANDR
Androgen receptor

1

5

High-throughput

0.479

High

834026

HNF4A
Hepatocyte nuclear factor 4-alpha

1

6

High-throughput

0.479

High

1295668

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

1

2

High-throughput

0.479

High

1391329

MED15
Mediator of RNA polymerase II transcription subunit 15

1

1

High-throughput

0.479

High

1391331

EPAS1
Endothelial PAS domain-containing protein 1

1

1

Small-scale

0.479

High

181550

TBXT
T-box transcription factor T

1

0

High-throughput

0.458

High

260295

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

316308

RECQ5
ATP-dependent DNA helicase Q5

1

0

High-throughput

0.458

High

326365

SCAF4
SR-related and CTD-associated factor 4

1

0

High-throughput

0.458

High

370755

FOS
Protein c-Fos

1

0

High-throughput

0.458

High

581714

MYOD1
Myoblast determination protein 1

1

0

High-throughput

0.458

High

714349

PML
Protein PML

1

0

High-throughput

0.458

High

787770

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.458

High

862370

YAP1
Transcriptional coactivator YAP1

1

0

High-throughput

0.458

High

912101

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

912213

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

0

High-throughput

0.458

High

920190

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.458

High

923521

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.458

High

959025

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

976130

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.458

High

983685

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.458

High

1033143

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

1088965

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1112953

CUL2
Cullin-2

1

0

Small-scale

0.458

High

1151369

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

1212019

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.458

High

1217603

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

0

High-throughput

0.458

High

1257804

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1313029

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

1391336

STN1
CST complex subunit STN1

1

0

High-throughput

0.458

High

95752

E5RFK5
Cyclin-C

1

1

High-throughput

0.445

High

533302

THA
Thyroid hormone receptor alpha

1

5

Small-scale

0.445

High

1227245

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

344285

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

1391330

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

76432

B4DUB1
cyclin-dependent kinase

1

3

High-throughput

0.407

High

352635

TCL1B
T-cell leukemia/lymphoma protein 1B

3

0

High-throughput

0.347

High

725439

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

2

0

High-throughput

0.316

High

1230194

K1C40
Keratin, type I cytoskeletal 40

1

0

High-throughput

0.299

High

1336435

PNMA1
Paraneoplastic antigen Ma1

1

0

High-throughput

0.299

High

1364764

PHYIP
Phytanoyl-CoA hydroxylase-interacting protein

1

0

High-throughput

0.282

High

518891

CCL3
C-C motif chemokine 3

1

0

High-throughput

0.279

Low

1348936

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

422865

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.261

Low

387549

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.249

Low

1141858

EEA1
Early endosome antigen 1

1

0

High-throughput

0.249

Low

1232002

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

1104798

SNTA1
Alpha-1-syntrophin

1

0

High-throughput

0.238

Low

1347796

UBAD1
UBA-like domain-containing protein 1

1

0

High-throughput

0.238

Low

1391339

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low

506019

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025