Protein: THA
Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha)

Gene: THA, THRA
Organism: Homo sapiens
Interactions: 93
UniProt ID: P10827

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

533290

NCOA1
Nuclear receptor coactivator 1

6

20

Small-scale

0.939

High

533245

RXRA
Retinoic acid receptor RXR-alpha

4

19

Small-scale

0.875

High

533287

NCOA2
Nuclear receptor coactivator 2

2

20

Small-scale

0.768

High

533289

MED1
Mediator of RNA polymerase II transcription subunit 1

9

20

Small-scale

0.753

High

278216

NCOR1
Nuclear receptor corepressor 1

7

20

Small-scale

0.747

High

533255

NRIP1
Nuclear receptor-interacting protein 1

5

16

Small-scale

0.708

High

533280

NCOA6
Nuclear receptor coactivator 6

4

20

Small-scale

0.685

High

533309

AMOL2
Angiomotin-like protein 2

3

14

High-throughput

0.675

High

533313

NCOR2
Nuclear receptor corepressor 2

3

20

Small-scale

0.651

High

533240

THA
Thyroid hormone receptor alpha

1

18

Small-scale

0.647

High

533283

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

19

Small-scale

0.647

High

282350

MED24
Mediator of RNA polymerase II transcription subunit 24

3

6

Small-scale

0.633

High

533297

CEP76
Centrosomal protein of 76 kDa

3

0

High-throughput

0.633

High

188155

HDAC3
Histone deacetylase 3

2

20

Small-scale

0.624

High

533274

CENPR
Centromere protein R

2

2

Small-scale

0.622

High

533264

IMA5
Importin subunit alpha-5

1

7

Small-scale

0.618

High

533314

NCOA3
Nuclear receptor coactivator 3

1

20

Small-scale

0.618

High

533265

CSN2
COP9 signalosome complex subunit 2

2

6

Small-scale

0.614

High

533312

GRIP1
Glutamate receptor-interacting protein 1

2

14

Small-scale

0.614

High

533275

MED21
Mediator of RNA polymerase II transcription subunit 21

2

3

Small-scale

0.606

High

280992

TACC1
Transforming acidic coiled-coil-containing protein 1

2

13

High-throughput

0.606

High

533250

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

2

4

High-throughput

0.606

High

180675

TIF1A
Transcription intermediary factor 1-alpha

2

20

Small-scale

0.595

High

486891

PARP1
Poly [ADP-ribose] polymerase 1

2

11

Small-scale

0.584

High

533301

SYAP1
Synapse-associated protein 1

2

0

High-throughput

0.580

High

533300

TRI63
E3 ubiquitin-protein ligase TRIM63

1

15

Small-scale

0.578

High

533303

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

11

High-throughput

0.573

High

533299

MED12
Mediator of RNA polymerase II transcription subunit 12

2

20

Small-scale

0.571

High

533311

MED16
Mediator of RNA polymerase II transcription subunit 16

2

4

Small-scale

0.571

High

533244

CREB1
Cyclic AMP-responsive element-binding protein 1

1

3

Small-scale

0.561

High

533267

PRKDC
DNA-dependent protein kinase catalytic subunit

1

11

Small-scale

0.561

High

533288

TRIPB
Thyroid receptor-interacting protein 11

1

10

Small-scale

0.561

High

533307

MED17
Mediator of RNA polymerase II transcription subunit 17

2

4

Small-scale

0.552

High

131113

CLIC1
Chloride intracellular channel protein 1

1

2

High-throughput

0.541

High

224218

BUB3
Mitotic checkpoint protein BUB3

1

12

High-throughput

0.541

High

533293

AMOT
Angiomotin

1

20

High-throughput

0.541

High

533298

FOXJ1
Forkhead box protein J1

1

20

High-throughput

0.541

High

533306

ZBTB3
Zinc finger and BTB domain-containing protein 3

1

20

High-throughput

0.541

High

533269

MEF2A
Myocyte-specific enhancer factor 2A

1

0

Small-scale

0.537

High

533254

HUTH
Histidine ammonia-lyase

1

1

High-throughput

0.536

High

533285

TAF11
Transcription initiation factor TFIID subunit 11

1

0

Small-scale

0.529

High

533292

TRXR1
Thioredoxin reductase 1, cytoplasmic

1

1

Small-scale

0.527

High

533294

Q6FHY5
MEOX2 protein

1

13

High-throughput

0.515

High

216369

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

20

Small-scale

0.501

High

261361

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

20

Small-scale

0.501

High

533243

PO2F1
POU domain, class 2, transcription factor 1

1

20

Small-scale

0.501

High

533248

1433T
14-3-3 protein theta

1

13

Small-scale

0.501

High

533253

FUS
RNA-binding protein FUS

1

18

Small-scale

0.501

High

533263

RT29
Small ribosomal subunit protein mS29

1

1

Small-scale

0.501

High

533266

UBC9
SUMO-conjugating enzyme UBC9

1

9

Small-scale

0.501

High

533268

TF2B
Transcription initiation factor IIB

1

3

Small-scale

0.501

High

533272

AKP13
A-kinase anchor protein 13

1

16

Small-scale

0.501

High

533276

TDG
G/T mismatch-specific thymine DNA glycosylase

1

3

Small-scale

0.501

High

533278

C1D
Nuclear nucleic acid-binding protein C1D

1

1

Small-scale

0.501

High

533282

TEBP
Prostaglandin E synthase 3

1

3

Small-scale

0.501

High

533304

RANB9
Ran-binding protein 9

1

15

Small-scale

0.501

High

533256

MTR1B
Melatonin receptor type 1B

1

1

High-throughput

0.494

High

533291

CYTM
Cystatin-M

1

1

High-throughput

0.489

High

533260

MEOX2
Homeobox protein MOX-2

1

16

High-throughput

0.481

High

533262

CDK7
Cyclin-dependent kinase 7

1

9

Small-scale

0.481

High

533270

ARI5A
AT-rich interactive domain-containing protein 5A

1

20

Small-scale

0.481

High

533277

CUL1
Cullin-1

1

10

High-throughput

0.481

High

533295

MED25
Mediator of RNA polymerase II transcription subunit 25

1

7

Small-scale

0.481

High

221022

HAIR
Lysine-specific demethylase hairless

1

5

Small-scale

0.479

High

287758

MED6
Mediator of RNA polymerase II transcription subunit 6

1

3

Small-scale

0.479

High

334670

IPO7
Importin-7

1

3

Small-scale

0.479

High

533241

XRCC6
X-ray repair cross-complementing protein 6

1

14

Small-scale

0.479

High

533242

XRCC5
X-ray repair cross-complementing protein 5

1

14

Small-scale

0.479

High

533246

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

533247

CCND1
G1/S-specific cyclin-D1

1

7

Small-scale

0.479

High

533249

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

10

Small-scale

0.479

High

533251

AKT1
RAC-alpha serine/threonine-protein kinase

1

15

High-throughput

0.479

High

533252

HSP74
Heat shock 70 kDa protein 4

1

18

Small-scale

0.479

High

533257

CDK8
Cyclin-dependent kinase 8

1

20

Small-scale

0.479

High

533259

DNLI3
DNA ligase 3

1

3

Small-scale

0.479

High

533261

EMD
Emerin

1

2

Small-scale

0.479

High

533271

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.479

High

533273

GPS2
G protein pathway suppressor 2

1

4

Small-scale

0.479

High

533279

SMC1A
Structural maintenance of chromosomes protein 1A

1

7

Small-scale

0.479

High

533281

IMB1
Importin subunit beta-1

1

3

Small-scale

0.479

High

533296

RHG24
Rho GTPase-activating protein 24

1

3

High-throughput

0.479

High

533305

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

20

Small-scale

0.479

High

533284

RGN
Regucalcin

1

0

High-throughput

0.460

High

533286

TAF7
Transcription initiation factor TFIID subunit 7

1

0

Small-scale

0.458

High

239531

MED14
Mediator of RNA polymerase II transcription subunit 14

1

20

Small-scale

0.445

High

533302

MED8
Mediator of RNA polymerase II transcription subunit 8

1

5

Small-scale

0.445

High

533308

MED29
Mediator of RNA polymerase II transcription subunit 29

1

1

Small-scale

0.445

High

533310

TR150
Thyroid hormone receptor-associated protein 3

1

11

Small-scale

0.445

High

75649

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

1

High-throughput

0.437

High

69469

A2ML1
Alpha-2-macroglobulin-like protein 1

1

1

High-throughput

0.407

High

351813

BY55
CD160 antigen

2

0

High-throughput

0.316

High

533258

SEPP1
Selenoprotein P

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025