Protein: MED8
Mediator of RNA polymerase II transcription subunit 8 (Mediator complex subunit 8)

Gene: MED8, mdt-8
Organism: Caenorhabditis elegans
Interactions: 45
UniProt ID: Q9U1W2

Gene Ontology (top 5):
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003712 - transcription coregulator activity
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0016592 - mediator complex
GO:0070847 - core mediator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

196773

O18173
PAW domain-containing protein

1

1

High-throughput

0.512

High

113669

MDL1
Mad-like protein 1

1

2

High-throughput

0.508

High

113790

HIF1
Hypoxia-inducible factor 1

1

1

High-throughput

0.508

High

145863

NHR62
Nuclear hormone receptor family member nhr-62

1

5

High-throughput

0.508

High

836245

NHR23
Nuclear hormone receptor family member nhr-23

1

2

High-throughput

0.508

High

1164731

NHR47
Nuclear hormone receptor family member nhr-47

1

10

High-throughput

0.508

High

1166235

MXL3
Protein mxl-3

1

2

High-throughput

0.508

High

1166764

Q19496
Nuclear Hormone Receptor family

1

6

High-throughput

0.508

High

1445220

NHR5
Nuclear hormone receptor family member nhr-5

1

9

High-throughput

0.508

High

195828

FOXO
Forkhead box protein O

1

0

High-throughput

0.486

High

479013

MEC3
Mechanosensory protein 3

1

0

High-throughput

0.486

High

1165953

HM43
Homeobox protein ceh-43

1

0

High-throughput

0.486

High

1166490

UNC98
Zinc finger protein unc-98

1

0

High-throughput

0.486

High

1166715

ZTF2
Zinc finger protein ztf-2

1

0

High-throughput

0.486

High

1166891

Q19807
C2H2-type domain-containing protein

1

0

High-throughput

0.486

High

1171069

PAT9
Zinc finger protein pat-9

1

0

High-throughput

0.486

High

1204727

NFI1
Nuclear factor I family protein

1

0

High-throughput

0.486

High

1445081

UNC62
Homeobox protein unc-62

1

0

High-throughput

0.486

High

1457740

Q9TXN8
DM domain-containing protein

1

0

High-throughput

0.486

High

1270241

Q7KX66
Nuclear receptor domain-containing protein

1

8

High-throughput

0.481

High

196378

EYA1
Protein phosphatase eya-1

1

1

High-throughput

0.464

High

1165854

FLH2
FLYWCH transcription factor 2

1

1

High-throughput

0.464

High

1445251

Q9NAE4
BZIP domain-containing protein

1

1

High-throughput

0.464

High

115451

H2KZA1
Nuclear hormone receptor E75

1

5

High-throughput

0.457

High

145601

SWIC2
SWI/SNF chromatin-remodeling accessory subunit 2

1

1

High-throughput

0.445

High

112274

G5EE45
BZIP domain-containing protein

1

1

High-throughput

0.439

High

1018798

HMP1
Alpha-catenin-like protein hmp-1

1

1

High-throughput

0.439

High

1230719

Q6AHQ8
SH3 domain-containing protein

1

1

High-throughput

0.439

High

1285873

Q86DC0
SAM domain-containing protein

1

1

High-throughput

0.439

High

1302116

Q8I7K9
LIn-26 Related

1

1

High-throughput

0.439

High

63573

A5JYX3
Vinculin

1

1

High-throughput

0.417

High

109763

G5EBR0
LIR-1A protein

1

1

High-throughput

0.417

High

1068781

Q09989
SH3 domain-containing protein

1

1

High-throughput

0.417

High

1166175

Q18662
Caskin-2

1

1

High-throughput

0.417

High

1457886

Q9U1S5
BZIP domain-containing protein

1

1

High-throughput

0.417

High

1457901

FLH1
FLYWCH transcription factor 1

1

1

High-throughput

0.417

High

1457763

Q9TZ50
CCDC92/74 N-terminal domain-containing protein

1

0

High-throughput

0.292

High

1457902

F161
Protein fam-161

1

0

High-throughput

0.282

High

107677

APTF2
Transcription factor aptf-2

1

0

High-throughput

0.265

Low

1166009

Q18426
TPR_REGION domain-containing protein

1

0

High-throughput

0.265

Low

1166506

Q19212
RasGEF domain protein

1

0

High-throughput

0.265

Low

1444944

Q9N3H6
RING-type domain-containing protein

1

0

High-throughput

0.265

Low

1457900

MOE3
CCCH-type zinc finger protein moe-3

1

0

High-throughput

0.265

Low

233233

O44490
ELKS/RAB6-interacting/CAST family member 2

1

0

High-throughput

0.249

Low

1457537

Q9TXM1
Uncharacterized protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025