Protein: BIN1
Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1)

Gene: BIN1
Organism: Homo sapiens
Interactions: 124
UniProt ID: O00499

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0002020 - protease binding
GO:0005543 - phospholipid binding
GO:0005634 - nucleus
GO:0005635 - nuclear envelope

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

131220

AMPH
Amphiphysin

6

17

Small-scale

0.948

High

131284

BIN2
Bridging integrator 2

3

17

Small-scale

0.867

High

131173

BIN1
Myc box-dependent-interacting protein 1

3

17

Small-scale

0.835

High

131240

SOS1
Son of sevenless homolog 1

3

9

Small-scale

0.827

High

131198

TAU
Microtubule-associated protein tau

5

13

Small-scale

0.728

High

131265

RIN3
Ras and Rab interactor 3

4

18

Small-scale

0.713

High

131190

MYC
Myc proto-oncogene protein

4

2

Small-scale

0.707

High

131286

DP13A
DCC-interacting protein 13-alpha

1

3

High-throughput

0.698

High

131238

DYN1
Dynamin-1

1

20

Small-scale

0.681

High

131252

DGUOK
Deoxyguanosine kinase, mitochondrial

3

1

High-throughput

0.667

High

131285

NUFP1
FMR1-interacting protein NUFIP1

3

1

High-throughput

0.667

High

131197

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

14

Small-scale

0.647

High

131241

SOS2
Son of sevenless homolog 2

1

8

Small-scale

0.647

High

131243

PLD1
Phospholipase D1

1

3

Small-scale

0.647

High

131212

CLIP1
CAP-Gly domain-containing linker protein 1

2

3

Small-scale

0.640

High

131270

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

7

Small-scale

0.629

High

131217

CNDD3
Condensin-2 complex subunit D3

2

1

High-throughput

0.628

High

131186

SNX4
Sorting nexin-4

2

7

Small-scale

0.628

High

131237

E2F1
Transcription factor E2F1

2

1

Small-scale

0.624

High

131239

FAK1
Focal adhesion kinase 1

1

16

Small-scale

0.618

High

131242

ACK1
Activated CDC42 kinase 1

1

20

Small-scale

0.618

High

131290

DLGP4
Disks large-associated protein 4

1

2

Small-scale

0.586

High

131245

MTM1
Myotubularin

1

4

Small-scale

0.578

High

131264

REPS2
RalBP1-associated Eps domain-containing protein 2

1

19

Small-scale

0.578

High

131257

PKHA7
Pleckstrin homology domain-containing family A member 7

1

16

High-throughput

0.575

High

131266

SYNE2
Nesprin-2

1

10

Small-scale

0.573

High

131193

F16P1
Fructose-1,6-bisphosphatase 1

1

0

Small-scale

0.561

High

131244

XRCC4
DNA repair protein XRCC4

1

0

Small-scale

0.561

High

131228

RAP1A
Ras-related protein Rap-1A

1

13

Small-scale

0.561

High

131214

PE2R4
Prostaglandin E2 receptor EP4 subtype

1

1

High-throughput

0.541

High

131216

CUX1
Homeobox protein cut-like 1

1

2

High-throughput

0.541

High

131278

ZBTB3
Zinc finger and BTB domain-containing protein 3

1

2

High-throughput

0.541

High

131179

IPO8
Importin-8

1

1

High-throughput

0.536

High

131188

KLF8
Krueppel-like factor 8

1

5

High-throughput

0.536

High

131213

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.536

High

131223

GPM6A
Neuronal membrane glycoprotein M6-a

1

1

High-throughput

0.536

High

131232

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

131282

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

2

High-throughput

0.536

High

131196

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

2

0

High-throughput

0.528

High

131288

HECD1
E3 ubiquitin-protein ligase HECTD1

1

8

High-throughput

0.528

High

131222

DYN2
Dynamin-2

1

20

Small-scale

0.527

High

131187

SNAPN
SNARE-associated protein Snapin

1

0

High-throughput

0.518

High

131219

RFX3
Transcription factor RFX3

1

0

High-throughput

0.518

High

131226

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

0

High-throughput

0.518

High

131174

IRS4
Insulin receptor substrate 4

1

0

High-throughput

0.513

High

131263

CBARP
Voltage-dependent calcium channel beta subunit-associated regulatory protein

1

0

High-throughput

0.513

High

131248

FHL2
Four and a half LIM domains protein 2

1

11

Small-scale

0.508

High

126878

WASL
Actin nucleation-promoting factor WASL

1

20

Small-scale

0.501

High

131176

PLD2
Phospholipase D2

1

3

Small-scale

0.501

High

131189

AP2A1
AP-2 complex subunit alpha-1

1

20

Small-scale

0.501

High

131191

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

131233

ACTG
Actin, cytoplasmic 2

1

7

Small-scale

0.501

High

131235

ACTS
Actin, alpha skeletal muscle

1

6

Small-scale

0.501

High

131280

SAR1A
Small COPII coat GTPase SAR1A

1

5

High-throughput

0.489

High

131208

ITA6
Integrin alpha-6

1

2

Small-scale

0.481

High

131210

ITA3
Integrin alpha-3

1

2

Small-scale

0.481

High

131225

ITA1
Integrin alpha-1

1

2

Small-scale

0.481

High

131185

AP2A2
AP-2 complex subunit alpha-2

1

20

Small-scale

0.479

High

131192

FCG3A
Low affinity immunoglobulin gamma Fc region receptor III-A

1

1

Small-scale

0.479

High

131200

FCG2A
Low affinity immunoglobulin gamma Fc region receptor II-a

1

1

Small-scale

0.479

High

131206

SYN1
Synapsin-1

1

18

Small-scale

0.479

High

131215

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

131218

MUC18
Cell surface glycoprotein MUC18

1

1

High-throughput

0.479

High

131224

PLK1
Serine/threonine-protein kinase PLK1

1

2

Small-scale

0.479

High

131230

GRB2
Growth factor receptor-bound protein 2

1

17

High-throughput

0.479

High

131231

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

131236

CLH1
Clathrin heavy chain 1

1

5

Small-scale

0.479

High

131250

BECN1
Beclin-1

1

2

Small-scale

0.479

High

131251

GOGB1
Golgin subfamily B member 1

1

7

High-throughput

0.479

High

131260

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

131277

CHM4B
Charged multivesicular body protein 4b

1

2

Small-scale

0.479

High

131281

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

1

Small-scale

0.479

High

131283

HDAC6
Histone deacetylase 6

1

2

Small-scale

0.479

High

131199

CLUS
Clusterin

1

0

Small-scale

0.458

High

131203

EF2
Elongation factor 2

1

0

Small-scale

0.458

High

131205

BGAL
Beta-galactosidase

1

0

Small-scale

0.458

High

131247

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

Small-scale

0.458

High

131259

CDC73
Parafibromin

1

0

Small-scale

0.458

High

131276

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

Small-scale

0.458

High

131177

SYNJ2
Synaptojanin-2

1

10

High-throughput

0.457

High

131180

PEPL
Periplakin

1

13

High-throughput

0.457

High

131182

KS6A5
Ribosomal protein S6 kinase alpha-5

1

4

High-throughput

0.457

High

131183

PIAS1
E3 SUMO-protein ligase PIAS1

1

2

High-throughput

0.457

High

131184

PIAS2
E3 SUMO-protein ligase PIAS2

1

2

High-throughput

0.457

High

131194

PARP1
Poly [ADP-ribose] polymerase 1

1

5

High-throughput

0.457

High

131207

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

1

High-throughput

0.457

High

131209

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

9

High-throughput

0.457

High

131211

PAX6
Paired box protein Pax-6

1

1

High-throughput

0.457

High

131221

RBP2
E3 SUMO-protein ligase RanBP2

1

1

High-throughput

0.457

High

131227

STXB1
Syntaxin-binding protein 1

1

4

High-throughput

0.457

High

131246

FHL1
Four and a half LIM domains protein 1

1

9

High-throughput

0.457

High

131249

GAS6
Growth arrest-specific protein 6

1

5

High-throughput

0.457

High

131258

Q6NSK7
RIN3 protein

1

15

High-throughput

0.457

High

131261

RNB3L
Ran-binding protein 3-like

1

4

High-throughput

0.457

High

131267

RYR2
Ryanodine receptor 2

1

3

High-throughput

0.457

High

131268

RAB24
Ras-related protein Rab-24

1

7

High-throughput

0.457

High

131269

WBP2
WW domain-binding protein 2

1

5

High-throughput

0.457

High

131271

PWP2A
PWWP domain-containing protein 2A

1

4

High-throughput

0.457

High

131272

KS6C1
Ribosomal protein S6 kinase delta-1

1

4

High-throughput

0.457

High

131274

ZN251
Zinc finger protein 251

1

1

High-throughput

0.457

High

131279

RANB3
Ran-binding protein 3

1

4

High-throughput

0.457

High

131287

YETS2
YEATS domain-containing protein 2

1

4

High-throughput

0.457

High

131292

ZN451
E3 SUMO-protein ligase ZNF451

1

1

High-throughput

0.457

High

131293

PIAS3
E3 SUMO-protein ligase PIAS3

1

2

High-throughput

0.457

High

131195

MYZAP
Myocardial zonula adherens protein

1

5

High-throughput

0.445

High

131201

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.445

High

131202

XRCC5
X-ray repair cross-complementing protein 5

1

1

Small-scale

0.445

High

131175

PSA7
Proteasome subunit alpha type-7

1

0

High-throughput

0.438

High

131181

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

0

High-throughput

0.438

High

131204

KPYM
Pyruvate kinase PKM

1

0

High-throughput

0.438

High

131229

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.438

High

131234

UBC9
SUMO-conjugating enzyme UBC9

1

0

High-throughput

0.438

High

131254

MCAF2
Activating transcription factor 7-interacting protein 2

1

0

High-throughput

0.438

High

131255

Z518A
Zinc finger protein 518A

1

0

High-throughput

0.438

High

131262

AGRA3
Adhesion G protein-coupled receptor A3

1

0

High-throughput

0.438

High

131273

TSNAX
Translin-associated protein X

1

0

High-throughput

0.438

High

131275

GNL3
Guanine nucleotide-binding protein-like 3

1

0

High-throughput

0.438

High

131289

SIAT9
Lactosylceramide alpha-2,3-sialyltransferase

1

0

High-throughput

0.438

High

131291

MTF2
Metal-response element-binding transcription factor 2

1

0

High-throughput

0.438

High

131256

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

3

0

High-throughput

0.334

High

62836

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

2

0

High-throughput

0.316

High

131178

BCAT2
Branched-chain-amino-acid aminotransferase, mitochondrial

1

0

High-throughput

0.238

Low

131253

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024