HitPredict

Interactor 1: GDIB (P50395)
Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2)
Gene: GDI2

Interactor 2: RB11A (P62491)
Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (YL8)
Gene: RAB11A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.853

Property	Details
Experiments	10512627, 34079125, 35271311
Identification Methods	pull down, proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	GDI~Ras
Common GO terms	GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0016192 - vesicle-mediated transport GO:0031982 - vesicle GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 445 Hs			1 216
+	Hs
		678343 GDIA_HUMAN (1-444): 0: 714: 86.49		RB11A_HUMAN (1-216): 2.38e-94: 276: 100.00
+	Hs
		838647 GDIB_HUMAN (1-445): 0: 722: 100.00		RB11B_HUMAN (1-216): 2.54e-91: 268: 90.37
+	Hs
		838625 GDIB_HUMAN (1-445): 0: 722: 100.00		RAB1A_HUMAN (1-213): 1.31e-90: 266: 44.60
+	Mm
		838709 GDIA_MOUSE (1-444): 0: 717: 87.39		RAB1A_MOUSE (1-213): 1.31e-90: 266: 44.60
+	Hs
		678359 GDIA_HUMAN (1-444): 0: 714: 86.49		RB11B_HUMAN (1-216): 2.54e-91: 268: 90.37
+	Hs
		678344 GDIA_HUMAN (1-444): 0: 714: 86.49		RAB1A_HUMAN (1-213): 1.31e-90: 266: 44.60
+	Hs
		838683 GDIB_HUMAN (1-445): 0: 722: 100.00		RAB1B_HUMAN (4-213): 1.82e-87: 258: 46.19
+	Hs
		838614 GDIB_HUMAN (1-445): 0: 722: 100.00		RAB25_HUMAN (2-190): 8.31e-87: 256: 67.20
+	Hs
		678394 GDIA_HUMAN (1-444): 0: 714: 86.49		RAB1B_HUMAN (4-213): 1.82e-87: 258: 46.19
+	Dm
		185708 Q9VLB7_DROME (1-440): 0: 662: 67.80		O18335_DROME (1-214): 1.21e-88: 261: 85.51
+	Dm
		185501 Q9VLB7_DROME (1-440): 0: 662: 67.80		O18332_DROME (1-213): 6.44e-87: 257: 45.07
+	Hs
		838669 GDIB_HUMAN (1-445): 0: 722: 100.00		RAB2B_HUMAN (8-178): 6.71e-61: 191: 55.56
+	Hs
		678377 GDIA_HUMAN (1-444): 0: 714: 86.49		RAB2B_HUMAN (8-178): 6.71e-61: 191: 55.56
+	Sc
		750738 GDI1_YEAST (1-438): 0: 606: 54.16		YPT31_YEAST (1-213): 1.09e-98: 287: 60.54
+	Sp
		568530 GDI1_SCHPO (1-439): 0: 635: 56.14		YPT3_SCHPO (3-213): 7.41e-84: 249: 68.55
+	Sc
		765614 GDI1_YEAST (1-438): 0: 606: 54.16		YPT32_YEAST (7-213): 3.28e-86: 255: 61.50
+	Dm
		185694 RABEP_DROME (3-445): 7.84e-136: 401: 23.09		O18335_DROME (1-214): 1.21e-88: 261: 85.51
+	Sc
		699423 RAEP_YEAST (3-374): 2.36e-120: 365: 27.50		YPT31_YEAST (1-213): 1.09e-98: 287: 60.54
+	At
		656917 REP_ARATH (5-433): 1.78e-89: 284: 21.54		RAE1C_ARATH (7-213): 8.83e-84: 249: 43.27
+	At
		1228187 REP_ARATH (5-433): 1.78e-89: 284: 21.54		RAA5A_ARATH (5-193): 7.55e-82: 244: 63.49