Protein: IBTK
Inhibitor of Bruton tyrosine kinase (IBtk)

Gene: IBTK
Organism: Homo sapiens
Interactions: 128
UniProt ID: Q9P2D0

Gene Ontology (top 5):
GO:0001933 - negative regulation of protein phosphorylation
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0016020 - membrane
GO:0019901 - protein kinase binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1114513

CUL3
Cullin-3

10

20

Small-scale

0.972

High

954016

IF4A1
Eukaryotic initiation factor 4A-I

6

6

High-throughput

0.949

High

1054153

BTK
Tyrosine-protein kinase BTK

3

6

Small-scale

0.870

High

891844

GSK3B
Glycogen synthase kinase-3 beta

2

9

Small-scale

0.754

High

436748

KPCB
Protein kinase C beta type

1

6

Small-scale

0.724

High

658447

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.691

High

770069

RFC1
Replication factor C subunit 1

1

1

High-throughput

0.691

High

1247298

WDR74
WD repeat-containing protein 74

1

10

High-throughput

0.691

High

1271591

DHX30
ATP-dependent RNA helicase DHX30

1

4

High-throughput

0.691

High

1447831

DDX21
Nucleolar RNA helicase 2

1

8

High-throughput

0.691

High

294955

POP7
Ribonuclease P protein subunit p20

4

1

High-throughput

0.683

High

1124314

IF4A2
Eukaryotic initiation factor 4A-II

2

9

High-throughput

0.675

High

1143104

KPCD1
Serine/threonine-protein kinase D1

1

6

Small-scale

0.648

High

141688

DDX3X
ATP-dependent RNA helicase DDX3X

1

5

High-throughput

0.618

High

401622

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.618

High

603378

KPCA
Protein kinase C alpha type

1

6

Small-scale

0.618

High

619123

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

2

Small-scale

0.618

High

728454

AKT1
RAC-alpha serine/threonine-protein kinase

1

6

Small-scale

0.618

High

755642

TTK
Dual specificity protein kinase TTK

1

8

High-throughput

0.618

High

891340

GSK3A
Glycogen synthase kinase-3 alpha

1

8

High-throughput

0.618

High

1035027

KPCE
Protein kinase C epsilon type

1

5

Small-scale

0.618

High

1051977

KPCD
Protein kinase C delta type

1

6

Small-scale

0.618

High

1112751

CUL1
Cullin-1

1

20

Small-scale

0.618

High

1140970

KIF14
Kinesin-like protein KIF14

1

5

High-throughput

0.618

High

1146487

KS6A2
Ribosomal protein S6 kinase alpha-2

1

5

High-throughput

0.618

High

1228486

FTM
Protein fantom

1

12

High-throughput

0.618

High

1250681

BCOR
BCL-6 corepressor

1

10

High-throughput

0.618

High

1295586

MIB1
E3 ubiquitin-protein ligase MIB1

1

6

High-throughput

0.618

High

1334188

POC1A
POC1 centriolar protein homolog A

1

11

High-throughput

0.618

High

1380600

IGSF8
Immunoglobulin superfamily member 8

1

6

High-throughput

0.618

High

1454476

IBTK
Inhibitor of Bruton tyrosine kinase

1

16

Small-scale

0.618

High

346433

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

7

High-throughput

0.584

High

1198215

PDCD4
Programmed cell death protein 4

1

1

Small-scale

0.561

High

424682

KPCG
Protein kinase C gamma type

1

7

Small-scale

0.553

High

1065095

ITK
Tyrosine-protein kinase ITK/TSK

1

6

Small-scale

0.553

High

1327240

FBXL6
F-box/LRR-repeat protein 6

1

5

High-throughput

0.553

High

1396194

RPGR1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

1

14

High-throughput

0.553

High

1454479

HECD1
E3 ubiquitin-protein ligase HECTD1

1

14

High-throughput

0.553

High

429034

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.536

High

769794

RFC4
Replication factor C subunit 4

1

1

High-throughput

0.536

High

829282

RFC3
Replication factor C subunit 3

1

1

High-throughput

0.536

High

860392

RS9
Small ribosomal subunit protein uS4

1

2

High-throughput

0.536

High

969497

RS8
Small ribosomal subunit protein eS8

1

2

High-throughput

0.536

High

1131141

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

4

High-throughput

0.536

High

1144198

TEBP
Prostaglandin E synthase 3

1

2

High-throughput

0.536

High

1429633

NAT10
RNA cytidine acetyltransferase

1

1

High-throughput

0.536

High

352576

TOP3B
DNA topoisomerase 3-beta-1

2

2

High-throughput

0.533

High

1310664

Z3H7A
Zinc finger CCCH domain-containing protein 7A

2

12

High-throughput

0.533

High

833438

RGS2
Regulator of G-protein signaling 2

1

2

High-throughput

0.515

High

141152

NOP56
Nucleolar protein 56

1

0

High-throughput

0.513

High

428243

RLA1
Large ribosomal subunit protein P1

1

0

High-throughput

0.513

High

840815

RS27
Small ribosomal subunit protein eS27

1

0

High-throughput

0.513

High

1039434

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.513

High

1129580

ESPL1
Separin

1

0

High-throughput

0.513

High

1179385

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

0

High-throughput

0.513

High

968013

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

4

Small-scale

0.508

High

303647

SRP72
Signal recognition particle subunit SRP72

1

1

High-throughput

0.489

High

1013470

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

1

High-throughput

0.489

High

64141

CNOT1
CCR4-NOT transcription complex subunit 1

1

2

High-throughput

0.479

High

302656

RNF8
E3 ubiquitin-protein ligase RNF8

1

8

Small-scale

0.479

High

425661

ISG15
Ubiquitin-like protein ISG15

1

20

High-throughput

0.479

High

508752

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

15

Small-scale

0.479

High

589914

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

647673

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

7

Small-scale

0.479

High

694040

RL10
Large ribosomal subunit protein uL16

1

3

High-throughput

0.479

High

696735

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.479

High

769390

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

900539

FXR2
RNA-binding protein FXR2

1

8

High-throughput

0.479

High

954296

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

958725

CSN2
COP9 signalosome complex subunit 2

1

7

Small-scale

0.479

High

983998

RBX1
E3 ubiquitin-protein ligase RBX1

1

3

Small-scale

0.479

High

991264

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

1

High-throughput

0.479

High

1033800

PO5F1
POU domain, class 5, transcription factor 1

1

2

High-throughput

0.479

High

1101072

G3BP1
Ras GTPase-activating protein-binding protein 1

1

5

High-throughput

0.479

High

1106105

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

7

High-throughput

0.479

High

1123854

DCTN1
Dynactin subunit 1

1

5

High-throughput

0.479

High

1126562

CAPR1
Caprin-1

1

4

High-throughput

0.479

High

1137558

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

1143573

PCM1
Pericentriolar material 1 protein

1

1

High-throughput

0.479

High

1155845

EZH2
Histone-lysine N-methyltransferase EZH2

1

6

High-throughput

0.479

High

1219361

ECM29
Proteasome adapter and scaffold protein ECM29

1

3

High-throughput

0.479

High

1228916

MSL1
Male-specific lethal 1 homolog

1

1

High-throughput

0.479

High

1271231

DPPA4
Developmental pluripotency-associated protein 4

1

1

High-throughput

0.479

High

1275731

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

1

High-throughput

0.479

High

1280761

YTHD3
YTH domain-containing family protein 3

1

1

High-throughput

0.479

High

1289675

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

1291256

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

3

Small-scale

0.479

High

1331571

CE120
Centrosomal protein of 120 kDa

1

12

High-throughput

0.479

High

1335022

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

1350479

BICD2
Protein bicaudal D homolog 2

1

9

High-throughput

0.479

High

1352802

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

1357588

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

1358128

NUDC2
NudC domain-containing protein 2

1

16

High-throughput

0.479

High

1365690

LAR4B
La-related protein 4B

1

1

High-throughput

0.479

High

1367468

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1412829

PCGF1
Polycomb group RING finger protein 1

1

10

High-throughput

0.479

High

1413209

CSN4
COP9 signalosome complex subunit 4

1

2

Small-scale

0.479

High

1435393

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1435696

TDRD3
Tudor domain-containing protein 3

1

1

High-throughput

0.479

High

1437225

NANOG
Homeobox protein NANOG

1

5

High-throughput

0.479

High

1438727

CPAP
Centrosomal P4.1-associated protein

1

7

High-throughput

0.479

High

1451406

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.479

High

1454477

TRM7
tRNA

1

2

High-throughput

0.479

High

1454480

CSN3
COP9 signalosome complex subunit 3

1

6

Small-scale

0.479

High

1454482

MARE3
Microtubule-associated protein RP/EB family member 3

1

3

High-throughput

0.479

High

335924

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.458

High

615601

NELFE
Negative elongation factor E

1

0

High-throughput

0.458

High

948954

CD81
CD81 antigen

1

0

High-throughput

0.458

High

991949

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.458

High

1288987

EST1A
Telomerase-binding protein EST1A

1

0

High-throughput

0.458

High

1398217

CBPC4
Cytosolic carboxypeptidase 4

1

0

High-throughput

0.458

High

1409555

B9D2
B9 domain-containing protein 2

1

0

High-throughput

0.458

High

117110

J3QQY0
Male-specific lethal 1 homolog

1

1

High-throughput

0.445

High

1141986

EEA1
Early endosome antigen 1

1

9

High-throughput

0.437

High

1203276

ODFP2
Outer dense fiber protein 2

1

4

High-throughput

0.437

High

1226302

CP135
Centrosomal protein of 135 kDa

1

6

High-throughput

0.437

High

1256619

CE128
Centrosomal protein of 128 kDa

1

11

High-throughput

0.437

High

1438879

MOV10
Helicase MOV-10

1

3

High-throughput

0.437

High

1454481

CP131
Centrosomal protein of 131 kDa

1

5

High-throughput

0.437

High

91886

C9JYM0
Ribonuclease P protein subunit p20

1

1

High-throughput

0.407

High

1328040

RP25L
Ribonuclease P protein subunit p25-like protein

4

0

High-throughput

0.360

High

1454478

LTOR3
Ragulator complex protein LAMTOR3

1

0

High-throughput

0.251

Low

326626

MFN2
Mitofusin-2

1

0

High-throughput

0.249

Low

1004298

F193A
Protein FAM193A

1

0

High-throughput

0.249

Low

1217456

GKAP1
G kinase-anchoring protein 1

1

0

High-throughput

0.249

Low

1421221

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.249

Low

1451633

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025