HitPredict

Interactor 1: SPB9 (P50453)
Serpin B9 (Cytoplasmic antiproteinase 3) (CAP-3) (CAP3) (Peptidase inhibitor 9) (PI-9)
Gene: SERPINB9

Interactor 2: GRAM (P51124)
Granzyme M (EC 3.4.21.-) (Met-1 serine protease) (Hu-Met-1) (Met-ase) (Natural killer cell granular protease)
Gene: GZMM

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	15494398
Identification Methods	protease assay
Interaction Type	protein cleavage

Property	Details
Interacting Pfam domains	Serpin~Trypsin
Common GO terms	GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 376 Hs			1 257
+	Hs
		428671 SPB8_HUMAN (1-376): 3.08e-162: 461: 61.17		TRY1_HUMAN (5-257): 5.77e-109: 316: 31.27
+	Hs
		719380 SPB6_HUMAN (1-376): 4e-160: 455: 61.74		TM11A_HUMAN (11-255): 1.81e-97: 293: 27.60
+	Hs
		719387 SPB6_HUMAN (1-376): 4e-160: 455: 61.74		KLK13_HUMAN (28-255): 2.55e-99: 292: 34.89
+	Mm
		1141519 SPB6_MOUSE (1-376): 1.07e-157: 449: 60.89		KLK8_MOUSE (8-253): 2.41e-96: 284: 32.41
+	Hs
		344283 AACT_HUMAN (4-376): 3.51e-145: 419: 33.51		GRAM_HUMAN (1-257): 1.22e-107: 313: 100.00
+	Hs
		714770 SPB12_HUMAN (1-376): 8.89e-146: 420: 38.42		TRY3_HUMAN (12-257): 1.2e-104: 307: 32.80
+	Hs
		344178 A1AT_HUMAN (2-376): 5.21e-142: 411: 33.77		GRAM_HUMAN (1-257): 1.22e-107: 313: 100.00
+	Hs
		344097 ANT3_HUMAN (3-376): 5.58e-148: 428: 36.82		KLK1_HUMAN (5-257): 8.51e-98: 288: 28.73
+	Hs
		344349 AACT_HUMAN (4-376): 3.51e-145: 419: 33.51		KLK13_HUMAN (28-255): 2.55e-99: 292: 34.89
+	Hs
		177775 A1AT_HUMAN (2-376): 5.21e-142: 411: 33.77		TMPS2_HUMAN (5-257): 2.28e-98: 297: 27.69
+	Hs
		344148 A1AT_HUMAN (2-376): 5.21e-142: 411: 33.77		KLK1_HUMAN (5-257): 8.51e-98: 288: 28.73
+	Hs
		486155 SPB9_HUMAN (1-376): 4.14e-180: 506: 100.00		GRAB_HUMAN (25-255): 4.24e-39: 137: 36.82
+	Hs
		621770 ILEU_HUMAN (1-376): 4.29e-161: 458: 49.47		PRTN3_HUMAN (25-255): 1.19e-33: 124: 37.24
+	Hs
		439065 ILEU_HUMAN (1-376): 4.29e-161: 458: 49.47		ELNE_HUMAN (3-256): 8.52e-31: 117: 33.07
+	Hs
		589593 SPB6_HUMAN (1-376): 4e-160: 455: 61.74		KLK2_HUMAN (9-250): 2.31e-31: 118: 35.25
+	Hs
		344100 ANT3_HUMAN (3-376): 5.58e-148: 428: 36.82		GRAA_HUMAN (25-249): 3.86e-39: 138: 37.50
+	Hs
		344274 AACT_HUMAN (4-376): 3.51e-145: 419: 33.51		KLK2_HUMAN (9-250): 2.31e-31: 118: 35.25
+	Hs
		344265 AACT_HUMAN (4-376): 3.51e-145: 419: 33.51		ELNE_HUMAN (3-256): 8.52e-31: 117: 33.07
+	Hs
		344162 A1AT_HUMAN (2-376): 5.21e-142: 411: 33.77		PRTN3_HUMAN (25-255): 1.19e-33: 124: 37.24
+	Hs
		344151 A1AT_HUMAN (2-376): 5.21e-142: 411: 33.77		ELNE_HUMAN (3-256): 8.52e-31: 117: 33.07