Protein: PI4KA
Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha)

Gene: PI4KA
Organism: Homo sapiens
Interactions: 139
UniProt ID: P42356

Gene Ontology (top 5):
GO:0004430 - 1-phosphatidylinositol 4-kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

839450

CD83
CD83 antigen

2

1

High-throughput

0.712

High

839459

CD226
CD226 antigen

2

7

High-throughput

0.712

High

839474

TTC7B
Tetratricopeptide repeat protein 7B

2

5

High-throughput

0.712

High

839517

TTC7A
Tetratricopeptide repeat protein 7A

2

3

Small-scale

0.712

High

839520

VSIG4
V-set and immunoglobulin domain-containing protein 4

2

3

High-throughput

0.712

High

839479

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

2

2

High-throughput

0.637

High

839510

STRN4
Striatin-4

1

4

High-throughput

0.590

High

62739

PI4P2
Putative phosphatidylinositol 4-kinase alpha-like protein P2

1

12

High-throughput

0.575

High

593817

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

4

High-throughput

0.575

High

821699

CD79B
B-cell antigen receptor complex-associated protein beta chain

1

1

High-throughput

0.575

High

839437

PP2BC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

1

4

High-throughput

0.575

High

839464

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.575

High

50507

HACL2
2-hydroxyacyl-CoA lyase 2

2

1

High-throughput

0.552

High

217923

TGON2
Trans-Golgi network integral membrane protein 2

2

8

High-throughput

0.552

High

379924

HLAB
HLA class I histocompatibility antigen, B alpha chain

2

3

High-throughput

0.552

High

619579

VCAM1
Vascular cell adhesion protein 1

2

2

High-throughput

0.552

High

630142

ACM3
Muscarinic acetylcholine receptor M3

2

5

High-throughput

0.552

High

638395

FPR1
fMet-Leu-Phe receptor

2

13

High-throughput

0.552

High

770829

OPRM
Mu-type opioid receptor

2

8

High-throughput

0.552

High

839439

NPY2R
Neuropeptide Y receptor type 2

2

8

High-throughput

0.552

High

839440

MTR1B
Melatonin receptor type 1B

2

8

Small-scale

0.552

High

839484

F174A
Membrane protein FAM174A

2

2

High-throughput

0.552

High

839495

OPALI
Opalin

2

2

High-throughput

0.552

High

839501

HYCCI
Hyccin

2

3

High-throughput

0.552

High

839518

CAH14
Carbonic anhydrase 14

2

3

High-throughput

0.552

High

568541

TNNT1
Troponin T, slow skeletal muscle

1

1

High-throughput

0.457

High

839508

RM44
Large ribosomal subunit protein mL44

1

1

High-throughput

0.457

High

69481

A2ML1
Alpha-2-macroglobulin-like protein 1

1

3

High-throughput

0.445

High

133232

P2Y10
Putative P2Y purinoceptor 10

1

20

High-throughput

0.445

High

166263

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

2

High-throughput

0.445

High

182488

GP182
G-protein coupled receptor 182

1

16

High-throughput

0.445

High

250493

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

2

High-throughput

0.445

High

289243

SPB7
Serpin B7

1

11

High-throughput

0.445

High

296760

ST1C4
Sulfotransferase 1C4

1

1

High-throughput

0.445

High

351877

S1PR4
Sphingosine 1-phosphate receptor 4

1

11

High-throughput

0.445

High

384635

CRYAB
Alpha-crystallin B chain

1

2

High-throughput

0.445

High

389122

FINC
Fibronectin

1

1

High-throughput

0.445

High

395642

ESR1
Estrogen receptor

1

9

High-throughput

0.445

High

424488

PAI2
Plasminogen activator inhibitor 2

1

8

High-throughput

0.445

High

444927

S10A9
Protein S100-A9

1

8

High-throughput

0.445

High

457844

INVO
Involucrin

1

4

High-throughput

0.445

High

465443

IGF1R
Insulin-like growth factor 1 receptor

1

18

High-throughput

0.445

High

520770

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

3

High-throughput

0.445

High

551606

NFH
Neurofilament heavy polypeptide

1

9

High-throughput

0.445

High

563368

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

577659

PLAK
Junction plakoglobin

1

6

High-throughput

0.445

High

592715

LEUK
Leukosialin

1

2

High-throughput

0.445

High

627113

TYPH
Thymidine phosphorylase

1

2

High-throughput

0.445

High

635570

FILA
Filaggrin

1

10

High-throughput

0.445

High

652288

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

High-throughput

0.445

High

659132

LORI
Loricrin

1

1

High-throughput

0.445

High

692663

CALL3
Calmodulin-like protein 3

1

2

High-throughput

0.445

High

760411

SDC2
Syndecan-2

1

1

High-throughput

0.445

High

762108

CNR2
Cannabinoid receptor 2

1

7

Small-scale

0.445

High

771100

APJ
Apelin receptor

1

9

High-throughput

0.445

High

823587

ADH7
All-trans-retinol dehydrogenase [NAD(+)] ADH7

1

2

High-throughput

0.445

High

839433

HUTH
Histidine ammonia-lyase

1

2

High-throughput

0.445

High

839435

KI67
Proliferation marker protein Ki-67

1

4

High-throughput

0.445

High

839436

BAG6
Large proline-rich protein BAG6

1

1

High-throughput

0.445

High

839438

GSH0
Glutamate--cysteine ligase regulatory subunit

1

4

High-throughput

0.445

High

839442

EFNB2
Ephrin-B2

1

4

High-throughput

0.445

High

839443

LIMK1
LIM domain kinase 1

1

11

High-throughput

0.445

High

839444

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.445

High

839445

PAR2
Proteinase-activated receptor 2

1

19

High-throughput

0.445

High

839446

EVA1C
Protein eva-1 homolog C

1

1

High-throughput

0.445

High

839447

COPZ1
Coatomer subunit zeta-1

1

3

High-throughput

0.445

High

839448

BAT1
b(0,+)-type amino acid transporter 1

1

3

High-throughput

0.445

High

839449

IDD
Integral membrane protein DGCR2/IDD

1

1

High-throughput

0.445

High

839451

DSG1
Desmoglein-1

1

7

High-throughput

0.445

High

839452

DSC2
Desmocollin-2

1

7

High-throughput

0.445

High

839455

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

17

High-throughput

0.445

High

839456

EFR3A
Protein EFR3 homolog A

1

6

High-throughput

0.445

High

839457

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.445

High

839458

CDSN
Corneodesmosin

1

2

High-throughput

0.445

High

839460

ECM1
Extracellular matrix protein 1

1

2

High-throughput

0.445

High

839462

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

1

High-throughput

0.445

High

839463

UBR4
E3 ubiquitin-protein ligase UBR4

1

2

High-throughput

0.445

High

839466

PLBL1
Phospholipase B-like 1

1

2

High-throughput

0.445

High

839467

PKN3
Serine/threonine-protein kinase N3

1

7

High-throughput

0.445

High

839468

SBSN
Suprabasin

1

2

High-throughput

0.445

High

839470

FBX50
F-box only protein 50

1

2

High-throughput

0.445

High

839475

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

19

High-throughput

0.445

High

839476

SPA12
Serpin A12

1

11

High-throughput

0.445

High

839477

HYCC2
Hyccin 2

1

3

High-throughput

0.445

High

839478

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

1

High-throughput

0.445

High

839482

ARRD4
Arrestin domain-containing protein 4

1

14

High-throughput

0.445

High

839483

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

3

High-throughput

0.445

High

839485

PKR1
Prokineticin receptor 1

1

10

High-throughput

0.445

High

839487

ESR2
Estrogen receptor beta

1

9

High-throughput

0.445

High

839488

EVPL
Envoplakin

1

12

High-throughput

0.445

High

839489

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

6

High-throughput

0.445

High

839491

EFMT3
EEF1A lysine methyltransferase 3

1

2

High-throughput

0.445

High

839492

ARRD3
Arrestin domain-containing protein 3

1

14

High-throughput

0.445

High

839496

TESK2
Dual specificity testis-specific protein kinase 2

1

5

High-throughput

0.445

High

839497

SORT
Sortilin

1

2

High-throughput

0.445

High

839499

S39A3
Zinc transporter ZIP3

1

2

High-throughput

0.445

High

839502

ZDHC5
Palmitoyltransferase ZDHHC5

1

4

High-throughput

0.445

High

839503

SEM4C
Semaphorin-4C

1

8

High-throughput

0.445

High

839504

RNAS7
Ribonuclease 7

1

2

High-throughput

0.445

High

839505

TXNIP
Thioredoxin-interacting protein

1

14

High-throughput

0.445

High

839509

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.445

High

839511

S39A9
Zinc transporter ZIP9

1

2

High-throughput

0.445

High

839512

C5AR2
C5a anaphylatoxin chemotactic receptor 2

1

14

High-throughput

0.445

High

839513

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

2

High-throughput

0.445

High

839514

LAT2
Large neutral amino acids transporter small subunit 2

1

3

High-throughput

0.445

High

839515

SPB13
Serpin B13

1

8

High-throughput

0.445

High

839516

CC018
Uncharacterized protein C3orf18

1

2

High-throughput

0.445

High

839519

XCT
Cystine/glutamate transporter

1

3

High-throughput

0.445

High

839521

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

839522

EFR3B
Protein EFR3 homolog B

1

6

High-throughput

0.445

High

839523

GPR55
G-protein coupled receptor 55

1

20

High-throughput

0.445

High

839524

KLK5
Kallikrein-5

1

5

High-throughput

0.445

High

839525

GPR45
Probable G-protein coupled receptor 45

1

5

High-throughput

0.445

High

839526

NPTN
Neuroplastin

1

4

High-throughput

0.445

High

139187

UPK2
Uroplakin-2

1

0

High-throughput

0.426

High

839434

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.426

High

839465

S35E4
Solute carrier family 35 member E4

1

0

High-throughput

0.426

High

839471

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.426

High

839472

SV2A
Synaptic vesicle glycoprotein 2A

1

0

High-throughput

0.426

High

839481

NLS1
Sodium-dependent lysophosphatidylcholine symporter 1

1

0

High-throughput

0.426

High

839506

CH033
UPF0488 protein C8orf33

1

1

High-throughput

0.417

High

75556

B3KSW4
Regulator of G protein signaling 20

1

1

High-throughput

0.407

High

326672

DUS14
Dual specificity protein phosphatase 14

1

3

High-throughput

0.407

High

690006

CRBB3
Beta-crystallin B3

1

2

High-throughput

0.407

High

839441

KLK7
Kallikrein-7

1

5

High-throughput

0.407

High

839453

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.407

High

839454

FOXL1
Forkhead box protein L1

1

2

High-throughput

0.407

High

839461

INF2
Inverted formin-2

1

2

High-throughput

0.407

High

839469

PKHG7
Pleckstrin homology domain-containing family G member 7

1

5

High-throughput

0.407

High

839486

POF1B
Protein POF1B

1

2

High-throughput

0.407

High

839494

CMIP5
Ciliary microtubule inner protein 5

1

1

High-throughput

0.407

High

839500

RM01
Large ribosomal subunit protein uL1m

1

1

High-throughput

0.407

High

839507

MED20
Mediator of RNA polymerase II transcription subunit 20

1

1

High-throughput

0.407

High

653174

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

839473

RIC3
Protein RIC-3

1

0

High-throughput

0.232

Low

839480

CI163
Uncharacterized protein C9orf163

1

0

High-throughput

0.232

Low

839490

SNX21
Sorting nexin-21

1

0

High-throughput

0.232

Low

839493

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low

839498

ZBT18
Zinc finger and BTB domain-containing protein 18

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025