HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: LRSM1 (Q6UWE0)
E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL)
Gene: LRSAM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.857

Property	Details
Experiments	26811492, 28335037, 19549727
Identification Methods	pull down, enzymatic study, two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0000209 - protein polyubiquitination GO:0004842 - ubiquitin-protein transferase activity GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 147 Hs			1 723
+	Hs
		1165227 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		LRSM1_HUMAN (1-723): 4.35e-103: 333: 100.00
+	Hs
		919756 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		LRSM1_HUMAN (1-723): 4.35e-103: 333: 100.00
+	Hs
		895817 UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44		LRSM1_HUMAN (1-723): 4.35e-103: 333: 100.00
+	Hs
		851826 UB2E1_HUMAN (4-146): 3.94e-72: 216: 62.94		LRSM1_HUMAN (1-723): 4.35e-103: 333: 100.00
+	Hs
		896468 UBE2N_HUMAN (4-147): 1.92e-68: 205: 45.83		LRSM1_HUMAN (1-723): 4.35e-103: 333: 100.00
+	Zm
		21257 A0A1D6LKH6_MAIZE (2-144): 7e-70: 209: 44.76		A0A1D6HSI7_MAIZE (3-306): 3.53e-52: 197: 15.81