HitPredict

Interactor 1: KS6A3 (P51812)
Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2)
Gene: RPS6KA3

Interactor 2: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 740 Hs			1 337
+	Hs
		153900 KS6A3_HUMAN (1-740): 0: 844: 100.00		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Hs
		1073423 KS6A1_HUMAN (1-740): 0: 783: 77.90		NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00
+	Hs
		1073438 KS6A1_HUMAN (1-740): 0: 783: 77.90		PZRN4_HUMAN (5-336): 1.72e-40: 153: 15.92
+	Hs
		1073491 KS6A1_HUMAN (1-740): 0: 783: 77.90		WHRN_HUMAN (3-250): 2.49e-40: 152: 22.22
+	Hs
		850651 KS6A3_HUMAN (1-740): 0: 844: 100.00		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		850702 KS6A3_HUMAN (1-740): 0: 844: 100.00		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71
+	Hs
		1073444 KS6A1_HUMAN (1-740): 0: 783: 77.90		MAGI2_HUMAN (3-192): 5.72e-19: 90: 17.19
+	Hs
		1073434 KS6A1_HUMAN (1-740): 0: 783: 77.90		MAGI3_HUMAN (14-296): 6.63e-18: 86.9: 18.15
+	Hs
		1073470 KS6A1_HUMAN (1-740): 0: 783: 77.90		MAGI1_HUMAN (2-204): 1.44e-16: 83.1: 21.95
+	Hs
		942348 KS6A1_HUMAN (1-740): 0: 783: 77.90		DLG4_HUMAN (106-233): 1.85e-14: 76.2: 21.48
+	Hs
		1049960 KS6A1_HUMAN (1-740): 0: 783: 77.90		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		1073433 KS6A1_HUMAN (1-740): 0: 783: 77.90		NHRF3_HUMAN (148-263): 7.43e-11: 65: 28.45
+	Hs
		1073467 KS6A1_HUMAN (1-740): 0: 783: 77.90		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71
+	Hs
		153882 AKT1_HUMAN (327-739): 2.87e-125: 383: 21.02		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Hs
		681891 AKT1_HUMAN (327-739): 2.87e-125: 383: 21.02		NHRF3_HUMAN (148-263): 7.43e-11: 65: 28.45
+	Hs
		682200 AKT2_HUMAN (327-739): 1.82e-126: 387: 21.76		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71
+	Mm
		1143553 KS6A2_MOUSE (7-327): 4.77e-104: 336: 24.93		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Hs
		1021498 KS6A2_HUMAN (7-327): 3.91e-100: 326: 24.02		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Hs
		1049957 KS6A2_HUMAN (7-327): 3.91e-100: 326: 24.02		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		117007 SGK1_HUMAN (428-724): 5.73e-27: 116: 29.36		NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00