HitPredict

Interactor 1: AFF1 (P51825)
AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4)
Gene: AFF1

Interactor 2: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.50	0.574

Property	Details
Experiments	20153263, 21030982
Identification Methods	affinity chromatography technology, biochemical, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 3969
+	Hs
		975340 AFF4_HUMAN (10-1208): 2.3e-90: 318: 34.44		KMT2A_HUMAN (1-3969): 0: 3187: 100.00
+	Hs
		975290 Q8TD98_HUMAN (213-831): 1.77e-38: 155: 74.04		KMT2A_HUMAN (1-3969): 0: 3187: 100.00
+	Hs
		152630 KMT2D_HUMAN (357-1098): 8.96e-12: 72.4: 9.13		KMT2A_HUMAN (1-3969): 0: 3187: 100.00
+	Hs
		975251 NCOA6_HUMAN (66-930): 2.88e-09: 63.9: 8.55		KMT2A_HUMAN (1-3969): 0: 3187: 100.00
+	Hs
		850820 AFF1_HUMAN (1-1210): 3.61e-130: 431: 100.00		Q8TD98_HUMAN (1311-1447): 2.49e-58: 217: 98.54
+	Hs
		152700 KMT2D_HUMAN (357-1098): 8.96e-12: 72.4: 9.13		KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71
+	Hs
		1057802 NCOA6_HUMAN (66-930): 2.88e-09: 63.9: 8.55		KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71
+	Hs
		152654 KMT2D_HUMAN (357-1098): 8.96e-12: 72.4: 9.13		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		1056971 MDC1_HUMAN (161-949): 1.95e-10: 67.6: 10.79		SETD2_HUMAN (3398-3968): 1.14e-75: 285: 16.61
+	Hs
		152701 KMT2D_HUMAN (357-1098): 8.96e-12: 72.4: 9.13		SET1B_HUMAN (3529-3969): 1.64e-66: 254: 27.12
+	Hs
		1057804 NCOA6_HUMAN (66-930): 2.88e-09: 63.9: 8.55		SET1B_HUMAN (3529-3969): 1.64e-66: 254: 27.12
+	Hs
		331812 MDC1_HUMAN (161-949): 1.95e-10: 67.6: 10.79		NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23
+	Hs
		152553 KMT2D_HUMAN (357-1098): 8.96e-12: 72.4: 9.13		SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58
+	Hs
		1231748 AN36B_HUMAN (724-1142): 9.59e-52: 201: 14.42		MINT_HUMAN (418-1102): 7.18e-09: 64.7: 11.18
+	Mm
		1351630 PCLO_MOUSE (6-989): 7.06e-16: 85.9: 10.27		PCLO_MOUSE (755-1426): 4.31e-12: 75.3: 12.23
+	Hs
		152667 KMT2D_HUMAN (357-1098): 8.96e-12: 72.4: 9.13		KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23
+	Dm
		1376672 FUTSC_DROME (18-979): 6.66e-12: 72.6: 11.09		FUTSC_DROME (736-1358): 3.26e-10: 69.1: 12.74
+	Mm
		1207212 NCOA6_MOUSE (50-1088): 1.15e-11: 71.6: 9.93		KMT2C_MOUSE (337-1407): 2.62e-09: 66: 9.21
+	Hs
		1057773 NCOA6_HUMAN (66-930): 2.88e-09: 63.9: 8.55		KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23
+	Hs
		152645 NCOA6_HUMAN (66-930): 2.88e-09: 63.9: 8.55		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47