Protein: KI2L1
Killer cell immunoglobulin-like receptor 2DL1 (CD158 antigen-like family member A) (Natural killer-associated transcript 1) (NKAT-1) (p58 natural killer cell receptor clones CL-42/47.11) (p58 NK receptor CL-42/47.11) (p58.1 MHC class-I-specific NK receptor) (CD antigen CD158a)

Gene: KI2L1, KIR2DL1
Organism: Homo sapiens
Interactions: 43
UniProt ID: P43626

Gene Ontology (top 5):
GO:0002764 - immune response-regulating signaling pathway
GO:0002769 - natural killer cell inhibitory signaling pathway
GO:0005886 - plasma membrane
GO:0006955 - immune response
GO:0038023 - signaling receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

520775

HLAC
HLA class I histocompatibility antigen, C alpha chain

9

20

Small-scale

0.970

High

658861

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

2

High-throughput

0.691

High

850768

KI2L2
Killer cell immunoglobulin-like receptor 2DL2

1

15

High-throughput

0.691

High

850769

KI3L1
Killer cell immunoglobulin-like receptor 3DL1

1

14

High-throughput

0.691

High

850775

KI2S3
Killer cell immunoglobulin-like receptor 2DS3

1

15

High-throughput

0.691

High

3744

A0A142JA41
HLA-C alpha chain for Cw*18GB

1

20

Small-scale

0.647

High

47047

A0A583ZBW7
HLA-C protein

1

20

Small-scale

0.647

High

47050

A0A583ZBW8
HLA-C protein

1

20

Small-scale

0.647

High

90572

C1K0Y5
HLA class I antigen

1

20

Small-scale

0.647

High

91504

C9E8W1
HLA-C alpha chain

1

20

Small-scale

0.647

High

379932

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

20

Small-scale

0.647

High

850778

Q53YP1
HLA class I histocompatibility antigen C alpha chain

1

20

Small-scale

0.647

High

850779

Q5D1W8
HLA class I histocompatibility antigen C alpha chain

1

20

Small-scale

0.647

High

850780

Q5QT33
HLA class I antigen

1

20

Small-scale

0.647

High

850781

Q5RIP0
HLA class I histocompatibility antigen C alpha chain

1

20

Small-scale

0.647

High

850786

Q7YQB1
MHC class I antigen

1

20

Small-scale

0.647

High

850771

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

20

Small-scale

0.618

High

711055

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

20

Small-scale

0.588

High

850772

PTN11
Tyrosine-protein phosphatase non-receptor type 11

3

20

Small-scale

0.588

High

732468

ARRB2
Beta-arrestin-2

2

0

Small-scale

0.551

High

225950

STX6
Syntaxin-6

1

3

High-throughput

0.536

High

850776

VAMP3
Vesicle-associated membrane protein 3

1

3

High-throughput

0.536

High

850777

PLCH1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1

1

1

High-throughput

0.536

High

850782

STEA3
Metalloreductase STEAP3

1

1

High-throughput

0.536

High

850784

S27A4
Long-chain fatty acid transport protein 4

1

2

High-throughput

0.536

High

850785

RHDF2
Inactive rhomboid protein 2

1

3

High-throughput

0.536

High

850789

VANG1
Vang-like protein 1

1

1

High-throughput

0.536

High

850790

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

1

High-throughput

0.536

High

850791

MYADM
Myeloid-associated differentiation marker

1

2

High-throughput

0.536

High

850792

PKP2
Plakophilin-2

1

2

High-throughput

0.536

High

850794

FLVC1
Choline/ethanolamine transporter FLVCR1

1

1

High-throughput

0.536

High

850787

LSR
Lipolysis-stimulated lipoprotein receptor

1

0

High-throughput

0.513

High

850795

S4A7
Sodium bicarbonate cotransporter 3

1

0

High-throughput

0.513

High

699638

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

1

Small-scale

0.494

High

249829

STX10
Syntaxin-10

1

3

High-throughput

0.489

High

850770

MLF1
Myeloid leukemia factor 1

1

1

High-throughput

0.489

High

850783

PHLB3
Pleckstrin homology-like domain family B member 3

1

2

High-throughput

0.489

High

850788

NXP20
Protein NOXP20

1

4

High-throughput

0.489

High

850793

F1142
Protein FAM114A2

1

4

High-throughput

0.489

High

336370

SVIL
Supervillin

1

0

Small-scale

0.438

High

331843

GOSR1
Golgi SNAP receptor complex member 1

1

0

High-throughput

0.279

Low

850773

SIAT6
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase

1

0

High-throughput

0.279

Low

850774

UBE4A
Ubiquitin conjugation factor E4 A

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025