HitPredict

Interactor 1: NEK2 (P51955)
Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1)
Gene: NEK2

Interactor 2: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	19637314
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 445 Hs			1 196
+	Hs
		925384 MARK2_HUMAN (2-425): 7.56e-123: 377: 23.56		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		900617 MARK2_HUMAN (2-425): 7.56e-123: 377: 23.56		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		915778 MARK2_HUMAN (2-425): 7.56e-123: 377: 23.56		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		545461 MARK2_HUMAN (2-425): 7.56e-123: 377: 23.56		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		436371 MARK2_HUMAN (2-425): 7.56e-123: 377: 23.56		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		951102 MARK2_HUMAN (2-425): 7.56e-123: 377: 23.56		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		892447 MARK2_HUMAN (2-425): 7.56e-123: 377: 23.56		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		894157 MARK2_HUMAN (2-425): 7.56e-123: 377: 23.56		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		564584 MARK2_HUMAN (2-425): 7.56e-123: 377: 23.56		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		120505 MARK2_HUMAN (2-425): 7.56e-123: 377: 23.56		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98
+	Hs
		894405 SIK2_HUMAN (2-396): 3.05e-111: 350: 25.47		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Rn
		871319 AAPK1_RAT (4-383): 1.2e-108: 333: 27.32		RAC1_RAT (1-196): 2.37e-79: 236: 55.10
+	Rn
		871208 AAPK1_RAT (4-383): 1.2e-108: 333: 27.32		RHOA_RAT (1-196): 3.27e-78: 233: 83.16
+	Hs
		894319 MARK4_HUMAN (5-324): 3.04e-109: 341: 28.04		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		894456 NEK6_HUMAN (7-262): 2.56e-50: 174: 37.69		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49