HitPredict

Interactor 1: NEK4 (P51957)
Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2)
Gene: NEK4

Interactor 2: RUVB2 (Q9Y230)
RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta)
Gene: RUVBL2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	25798074
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 841 Hs			1 463
+	Hs
		851751 NEK4_HUMAN (1-841): 0: 617: 100.00		RUVB1_HUMAN (8-451): 0: 655: 42.67
+	Hs
		682080 AKT1_HUMAN (1-330): 8.38e-132: 403: 23.44		RUVB2_HUMAN (1-463): 0: 718: 100.00
+	Hs
		1354261 KS6B2_HUMAN (6-405): 5.48e-130: 399: 21.79		RUVB2_HUMAN (1-463): 0: 718: 100.00
+	Hs
		1354263 KS6B2_HUMAN (6-405): 5.48e-130: 399: 21.79		RUVB1_HUMAN (8-451): 0: 655: 42.67
+	Hs
		1335914 NEK6_HUMAN (3-272): 2.47e-50: 181: 36.23		RUVB2_HUMAN (1-463): 0: 718: 100.00
+	Hs
		851373 NEK2_HUMAN (6-261): 2.63e-48: 179: 40.91		RUVB2_HUMAN (1-463): 0: 718: 100.00