Protein: NKX25
Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E)

Gene: NKX25, NKX2-5
Organism: Homo sapiens
Interactions: 68
UniProt ID: P52952

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

916113

TBX5
T-box transcription factor TBX5

2

20

Small-scale

0.825

High

184765

SHOX
Short stature homeobox protein

2

18

High-throughput

0.783

High

851476

GATA4
Transcription factor GATA-4

5

12

Small-scale

0.724

High

916115

NKX24
Homeobox protein Nkx-2.4

1

18

High-throughput

0.646

High

916078

GRB2
Growth factor receptor-bound protein 2

2

20

High-throughput

0.628

High

224957

TLX3
T-cell leukemia homeobox protein 3

1

19

High-throughput

0.618

High

832295

ID1
DNA-binding protein inhibitor ID-1

1

2

Small-scale

0.618

High

916082

ID2
DNA-binding protein inhibitor ID-2

1

2

Small-scale

0.618

High

916084

ID3
DNA-binding protein inhibitor ID-3

1

2

Small-scale

0.618

High

916108

FBLI1
Filamin-binding LIM protein 1

2

3

Small-scale

0.606

High

916099

CIP4
Cdc42-interacting protein 4

2

2

High-throughput

0.606

High

916103

KRA81
Keratin-associated protein 8-1

2

2

High-throughput

0.606

High

916110

RBPMS
RNA-binding protein with multiple splicing

2

4

High-throughput

0.606

High

916086

TLE3
Transducin-like enhancer protein 3

2

20

High-throughput

0.594

High

916093

HDAC1
Histone deacetylase 1

1

11

Small-scale

0.561

High

916109

JARD2
Protein Jumonji

1

20

Small-scale

0.561

High

194533

KDM6A
Lysine-specific demethylase 6A

1

7

Small-scale

0.552

High

916085

TLE1
Transducin-like enhancer protein 1

1

20

High-throughput

0.541

High

133102

FOXE1
Forkhead box protein E1

1

20

High-throughput

0.536

High

429566

JUN
Transcription factor Jun

1

11

High-throughput

0.536

High

916073

FOXA1
Hepatocyte nuclear factor 3-alpha

1

18

High-throughput

0.536

High

916083

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

1

High-throughput

0.536

High

916088

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.536

High

916092

SMAD4
Mothers against decapentaplegic homolog 4

1

11

High-throughput

0.536

High

916107

IASPP
RelA-associated inhibitor

1

12

High-throughput

0.536

High

916106

FBX25
F-box only protein 25

1

1

Small-scale

0.501

High

447718

TPM3
Tropomyosin alpha-3 chain

1

5

High-throughput

0.500

High

482864

TPM1
Tropomyosin alpha-1 chain

1

5

High-throughput

0.500

High

559280

XRCC5
X-ray repair cross-complementing protein 5

1

10

High-throughput

0.500

High

588275

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.500

High

695002

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.500

High

767766

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.500

High

786036

LONM
Lon protease homolog, mitochondrial

1

3

High-throughput

0.500

High

855009

NOP2
28S rRNA

1

2

High-throughput

0.500

High

894645

EMD
Emerin

1

3

High-throughput

0.500

High

907342

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

3

High-throughput

0.500

High

916076

RL37
Large ribosomal subunit protein eL37

1

1

High-throughput

0.500

High

916079

TPM4
Tropomyosin alpha-4 chain

1

5

High-throughput

0.500

High

916080

TFAM
Transcription factor A, mitochondrial

1

20

High-throughput

0.500

High

916087

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

5

High-throughput

0.500

High

916090

ILF2
Interleukin enhancer-binding factor 2

1

7

High-throughput

0.500

High

916095

LBR
Delta(14)-sterol reductase LBR

1

1

High-throughput

0.500

High

916100

JHD2C
Probable JmjC domain-containing histone demethylation protein 2C

1

1

High-throughput

0.500

High

916111

SMG1
Serine/threonine-protein kinase SMG1

1

6

High-throughput

0.500

High

916117

MAGD2
Melanoma-associated antigen D2

1

7

High-throughput

0.500

High

916118

SRRM2
Serine/arginine repetitive matrix protein 2

1

20

High-throughput

0.500

High

916119

PDIP2
Polymerase delta-interacting protein 2

1

2

High-throughput

0.500

High

323934

CMTA2
Calmodulin-binding transcription activator 2

1

0

Small-scale

0.480

High

301871

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.479

High

916089

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.479

High

916097

TCAL1
Transcription elongation factor A protein-like 1

1

0

High-throughput

0.479

High

916102

GLO2
Hydroxyacylglutathione hydrolase, mitochondrial

1

0

High-throughput

0.479

High

916074

PAX9
Paired box protein Pax-9

1

10

High-throughput

0.479

High

916075

SOX10
Transcription factor SOX-10

1

20

High-throughput

0.479

High

916077

RL39
Large ribosomal subunit protein eL39

1

1

High-throughput

0.479

High

916081

EWS
RNA-binding protein EWS

1

8

High-throughput

0.479

High

916096

EEA1
Early endosome antigen 1

1

5

High-throughput

0.479

High

916098

IRF4
Interferon regulatory factor 4

1

4

High-throughput

0.479

High

916105

SMC5
Structural maintenance of chromosomes protein 5

1

6

High-throughput

0.479

High

916112

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

916116

ELF5
ETS-related transcription factor Elf-5

1

17

High-throughput

0.479

High

888832

TMEDA
Transmembrane emp24 domain-containing protein 10

1

4

High-throughput

0.457

High

916091

TMED1
Transmembrane emp24 domain-containing protein 1

1

5

High-throughput

0.457

High

916101

DREB
Drebrin

1

8

High-throughput

0.457

High

916114

TMED9
Transmembrane emp24 domain-containing protein 9

1

3

High-throughput

0.457

High

142512

IMA3
Importin subunit alpha-3

1

3

High-throughput

0.408

High

916094

FLOT2
Flotillin-2

2

0

High-throughput

0.318

High

916104

DYH10
Dynein axonemal heavy chain 10

1

0

High-throughput

0.261

Low


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Last updated: 11Aug2025