HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: NISCH (Q9Y2I1)
Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein)
Gene: NISCH

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006915 - apoptotic process GO:0030336 - negative regulation of cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 1504
+	Hs
		925746 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		901063 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		545706 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		900678 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		S11IP_HUMAN (129-540): 2.54e-55: 213: 23.61
+	Hs
		915824 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		S11IP_HUMAN (129-540): 2.54e-55: 213: 23.61
+	Hs
		545490 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		S11IP_HUMAN (129-540): 2.54e-55: 213: 23.61
+	Hs
		925580 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		LGR4_HUMAN (100-537): 1.25e-40: 165: 15.65
+	Hs
		900857 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		LGR4_HUMAN (100-537): 1.25e-40: 165: 15.65
+	Dm
		776889 RAC1_DROME (1-196): 1.58e-77: 231: 53.06		SCRIB_DROME (229-691): 1.82e-38: 159: 16.77
+	Hs
		900538 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		DNAL1_HUMAN (299-414): 1.76e-36: 138: 31.03
+	Hs
		925419 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		LRC8A_HUMAN (209-418): 2.58e-21: 103: 21.82
+	Hs
		900667 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		LRC8A_HUMAN (209-418): 2.58e-21: 103: 21.82
+	Hs
		915813 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		LRC8A_HUMAN (209-418): 2.58e-21: 103: 21.82
+	Hs
		545486 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		LRC8A_HUMAN (209-418): 2.58e-21: 103: 21.82
+	Hs
		915930 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		LRRC1_HUMAN (202-471): 1.35e-19: 96.3: 21.22
+	Hs
		925273 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		SCRIB_HUMAN (209-577): 1.3e-17: 91.7: 18.01
+	Hs
		900463 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		SCRIB_HUMAN (209-577): 1.3e-17: 91.7: 18.01
+	Hs
		915673 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		SCRIB_HUMAN (209-577): 1.3e-17: 91.7: 18.01
+	Hs
		545370 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		SCRIB_HUMAN (209-577): 1.3e-17: 91.7: 18.01
+	Hs
		950989 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		SCRIB_HUMAN (209-577): 1.3e-17: 91.7: 18.01