HitPredict

Interactor 1: IMA5 (P52294)
Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed]
Gene: KPNA1

Interactor 2: SLX4 (Q8IY92)
Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
Gene: SLX4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	33961781, 19596235
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 538 Hs			1 1834
+	Hs
		134927 IMA3_HUMAN (1-538): 7e-156: 456: 45.84		SLX4_HUMAN (1-1834): 0: 1486: 100.00
+	Hs
		168655 IMA6_HUMAN (1-538): 1.39e-152: 449: 79.59		SLX4_HUMAN (1-1834): 0: 1486: 100.00
+	Hs
		131468 IMA4_HUMAN (3-538): 1.73e-150: 443: 45.91		SLX4_HUMAN (1-1834): 0: 1486: 100.00
+	Hs
		853363 IMA1_HUMAN (3-538): 1.64e-149: 441: 44.36		SLX4_HUMAN (1-1834): 0: 1486: 100.00
+	Hs
		801037 IMA5_HUMAN (1-538): 9.01e-156: 457: 100.00		KI67_HUMAN (889-1833): 3.44e-23: 110: 10.79
+	Hs
		134846 IMA3_HUMAN (1-538): 7e-156: 456: 45.84		KI67_HUMAN (889-1833): 3.44e-23: 110: 10.79
+	Hs
		238716 IMA7_HUMAN (1-538): 6.51e-160: 467: 80.48		CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57
+	Hs
		134941 IMA3_HUMAN (1-538): 7e-156: 456: 45.84		CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57
+	Hs
		853402 IMA1_HUMAN (3-538): 1.64e-149: 441: 44.36		CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57