Protein: HSF4
Heat shock factor protein 4 (HSF 4) (hHSF4) (Heat shock transcription factor 4) (HSTF 4)

Gene: HSF4
Organism: Homo sapiens
Interactions: 51
UniProt ID: Q9ULV5

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0016607 - nuclear speck

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1026587

HSF1
Heat shock factor protein 1

2

17

High-throughput

0.811

High

1044394

HSF2
Heat shock factor protein 2

2

17

High-throughput

0.811

High

1291748

SESD1
SEC14 domain and spectrin repeat-containing protein 1

4

1

High-throughput

0.638

High

288145

FOXH1
Forkhead box protein H1

2

2

High-throughput

0.606

High

942129

SOX10
Transcription factor SOX-10

2

1

High-throughput

0.606

High

1091264

FOXI1
Forkhead box protein I1

2

1

High-throughput

0.606

High

1461775

AKP8L
A-kinase anchor protein 8-like

2

1

High-throughput

0.606

High

192140

PA2GX
Group 10 secretory phospholipase A2

2

0

High-throughput

0.580

High

217224

MS18B
Protein Mis18-beta

2

0

High-throughput

0.580

High

1005654

PITX1
Pituitary homeobox 1

2

0

High-throughput

0.580

High

1414918

DUS26
Dual specificity protein phosphatase 26

1

0

Small-scale

0.561

High

903518

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

5

Small-scale

0.561

High

169790

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

1

High-throughput

0.553

High

300703

KRT37
Keratin, type I cuticular Ha7

2

3

High-throughput

0.553

High

300856

KRT38
Keratin, type I cuticular Ha8

2

3

High-throughput

0.553

High

447895

TPM3
Tropomyosin alpha-3 chain

2

5

High-throughput

0.553

High

789246

NUP62
Nuclear pore glycoprotein p62

2

4

High-throughput

0.553

High

1093737

MKRN3
E3 ubiquitin-protein ligase makorin-3

2

2

High-throughput

0.553

High

1146212

K1H1
Keratin, type I cuticular Ha1

2

3

High-throughput

0.553

High

1230313

K1C40
Keratin, type I cytoskeletal 40

2

3

High-throughput

0.553

High

1336248

LIPB2
Liprin-beta-2

2

1

High-throughput

0.553

High

1418758

YTHD1
YTH domain-containing family protein 1

2

1

High-throughput

0.553

High

703744

MK01
Mitogen-activated protein kinase 1

1

8

Small-scale

0.528

High

832834

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.513

High

1459008

DAXX
Death domain-associated protein 6

1

1

Small-scale

0.512

High

691876

MK03
Mitogen-activated protein kinase 3

1

8

Small-scale

0.506

High

1106121

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

3

High-throughput

0.489

High

1144899

RABE1
Rab GTPase-binding effector protein 1

1

1

High-throughput

0.489

High

1461776

SGT1
Protein SGT1 homolog

1

2

High-throughput

0.489

High

613223

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

50360

F168B
Myelin-associated neurite-outgrowth inhibitor

2

0

High-throughput

0.316

High

506795

NHLC4
NHL-repeat-containing protein 4

2

0

High-throughput

0.316

High

1186723

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.316

High

1186868

KR196
Keratin-associated protein 19-6

2

0

High-throughput

0.316

High

1187935

KR197
Keratin-associated protein 19-7

2

0

High-throughput

0.316

High

1203509

ACTMP
Actin maturation protease

2

0

High-throughput

0.316

High

1211153

CJ055
Uncharacterized protein C10orf55

2

0

High-throughput

0.316

High

1215024

INT11
Integrator complex subunit 11

2

0

High-throughput

0.316

High

1238981

UFSP1
Ufm1-specific protease 1

2

0

High-throughput

0.316

High

1359140

PIHD2
PIH1 domain-containing protein 2

2

0

High-throughput

0.316

High

1419142

KRA31
Keratin-associated protein 3-1

2

0

High-throughput

0.316

High

1429739

ZMY12
Zinc finger MYND domain-containing protein 12

2

0

High-throughput

0.316

High

1451947

GFOD1
Glucose-fructose oxidoreductase domain-containing protein 1

2

0

High-throughput

0.316

High

1103858

TARB1
tRNA

1

0

High-throughput

0.279

Low

1450428

FBX28
F-box only protein 28

1

0

High-throughput

0.279

Low

1461180

MYO15
Unconventional myosin-XV

1

0

High-throughput

0.279

Low

1461777

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

0

High-throughput

0.279

Low

228392

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.265

Low

299497

CDKA2
Cyclin-dependent kinase 2-associated protein 2

1

0

High-throughput

0.265

Low

1315884

F200C
Protein FAM200C

1

0

High-throughput

0.265

Low

1452176

ALKB4
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

1

0

Small-scale

0.265

Low


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Last updated: 11Aug2025