HitPredict

Interactor 1: JAK3 (P52333)
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)
Gene: JAK3

Interactor 2: H90B4 (Q58FF6)
Putative heat shock protein HSP 90-beta 4
Gene: HSP90AB4P

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	32707033
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1124 Hs			1 505
+	Hs
		438016 JAK3_HUMAN (1-1124): 0: 968: 100.00		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		431677 JAK3_HUMAN (1-1124): 0: 968: 100.00		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		238334 JAK2_HUMAN (7-1101): 0: 889: 47.80		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		238331 JAK2_HUMAN (7-1101): 0: 889: 47.80		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Dm
		365457 JAK_DROME (34-1118): 0: 562: 19.56		HSP83_DROME (1-504): 0: 669: 57.69
+	Hs
		437966 ABL2_HUMAN (794-1121): 3.94e-95: 331: 32.22		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		337314 ABL1_HUMAN (760-1102): 3.81e-95: 330: 29.48		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		437847 SRC_HUMAN (793-1109): 4.7e-100: 328: 29.25		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		433218 YES_HUMAN (784-1109): 7.17e-99: 326: 29.36		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		411556 LCK_HUMAN (794-1110): 1.37e-97: 321: 30.50		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Dm
		365472 SRC42_DROME (767-1111): 1.03e-97: 321: 29.89		HSP83_DROME (1-504): 0: 669: 57.69
+	Hs
		431626 ABL2_HUMAN (794-1121): 3.94e-95: 331: 32.22		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		337312 ABL1_HUMAN (760-1102): 3.81e-95: 330: 29.48		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		431481 SRC_HUMAN (793-1109): 4.7e-100: 328: 29.25		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		431433 YES_HUMAN (784-1109): 7.17e-99: 326: 29.36		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		411551 LCK_HUMAN (794-1110): 1.37e-97: 321: 30.50		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		411945 FYN_HUMAN (790-1109): 4.99e-97: 320: 29.60		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		433378 YES_HUMAN (784-1109): 7.17e-99: 326: 29.36		H90B4_HUMAN (1-505): 0: 644: 100.00
+	Hs
		433379 YES_HUMAN (784-1109): 7.17e-99: 326: 29.36		H90B3_HUMAN (1-504): 3.09e-143: 426: 58.87
+	Hs
		411751 LCK_HUMAN (794-1110): 1.37e-97: 321: 30.50		H90B3_HUMAN (1-504): 3.09e-143: 426: 58.87