HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: RBP10 (Q6VN20)
Ran-binding protein 10 (RanBP10)
Gene: RANBP10

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	19953087
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1319 Hs			1 620
+	Hs
		861571 NEDD4_HUMAN (1-1319): 0: 1940: 100.00		HNRPU_HUMAN (31-260): 2.1e-45: 174: 20.32
+	Hs
		861753 NEDD4_HUMAN (1-1319): 0: 1940: 100.00		HNRL1_HUMAN (32-260): 3.77e-43: 168: 20.24
+	Hs
		861648 NEDD4_HUMAN (1-1319): 0: 1940: 100.00		RN123_HUMAN (84-230): 3.35e-42: 165: 29.41
+	Hs
		1280422 HUWE1_HUMAN (799-1317): 4.45e-169: 562: 35.32		RANB9_HUMAN (19-620): 0: 665: 66.77
+	Hs
		1250507 NED4L_HUMAN (424-676): 1.65e-30: 133: 16.55		RBP10_HUMAN (1-620): 0: 751: 100.00
+	Hs
		1220863 HECW2_HUMAN (387-1317): 0: 696: 28.91		RN123_HUMAN (84-230): 3.35e-42: 165: 29.41
+	Hs
		1280367 HUWE1_HUMAN (799-1317): 4.45e-169: 562: 35.32		DDX1_HUMAN (9-349): 2.57e-74: 254: 17.60
+	Hs
		1027555 HUWE1_HUMAN (799-1317): 4.45e-169: 562: 35.32		HNRPU_HUMAN (31-260): 2.1e-45: 174: 20.32
+	Hs
		1280551 HUWE1_HUMAN (799-1317): 4.45e-169: 562: 35.32		GID8_HUMAN (232-441): 2.29e-48: 170: 14.35
+	Hs
		1220607 HUWE1_HUMAN (799-1317): 4.45e-169: 562: 35.32		RN123_HUMAN (84-230): 3.35e-42: 165: 29.41
+	Hs
		132189 WWP2_HUMAN (461-799): 1.62e-40: 164: 18.79		DDX1_HUMAN (9-349): 2.57e-74: 254: 17.60
+	Hs
		131962 WWP2_HUMAN (461-799): 1.62e-40: 164: 18.79		HNRPU_HUMAN (31-260): 2.1e-45: 174: 20.32
+	Hs
		132274 WWP2_HUMAN (461-799): 1.62e-40: 164: 18.79		HNRL1_HUMAN (32-260): 3.77e-43: 168: 20.24
+	Sc
		815548 RSP5_YEAST (388-653): 8.26e-28: 123: 13.51		EAR1_YEAST (28-233): 8.76e-43: 163: 24.78
+	Hs
		1027772 SMUF1_HUMAN (483-719): 1.25e-23: 110: 15.71		HNRPU_HUMAN (31-260): 2.1e-45: 174: 20.32
+	Hs
		1394601 ITCH_HUMAN (305-642): 6.68e-25: 114: 14.82		HNRL1_HUMAN (32-260): 3.77e-43: 168: 20.24
+	Hs
		1414336 SMUF1_HUMAN (483-719): 1.25e-23: 110: 15.71		HNRL1_HUMAN (32-260): 3.77e-43: 168: 20.24