Protein: GID8
Glucose-induced degradation protein 8 homolog (Two hybrid-associated protein 1 with RanBPM) (Twa1)

Gene: GID8
Organism: Homo sapiens
Interactions: 135
UniProt ID: Q9NWU2

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1402325

RANB9
Ran-binding protein 9

12

19

Small-scale

0.981

High

1436197

RMD5A
E3 ubiquitin-protein transferase RMND5A

9

17

Small-scale

0.974

High

1250530

RBP10
Ran-binding protein 10

6

17

High-throughput

0.940

High

1272754

MAEA
E3 ubiquitin-protein transferase MAEA

5

17

Small-scale

0.937

High

1451491

GID8
Glucose-induced degradation protein 8 homolog

3

17

Small-scale

0.865

High

1391445

RMD5B
E3 ubiquitin-protein transferase RMND5B

3

17

High-throughput

0.839

High

1307937

ARMC8
Armadillo repeat-containing protein 8

8

8

Small-scale

0.749

High

1435665

WDR26
WD repeat-containing protein 26

5

13

Small-scale

0.712

High

1451499

MKLN1
Muskelin

4

10

Small-scale

0.696

High

561391

TDGF1
Protein Cripto

4

5

High-throughput

0.691

High

216836

HTRA2
Serine protease HTRA2, mitochondrial

3

4

High-throughput

0.650

High

248362

HBP1
HMG box-containing protein 1

3

11

High-throughput

0.650

High

977165

YPEL5
Protein yippee-like 5

3

12

High-throughput

0.650

High

181446

PGRC2
Membrane-associated progesterone receptor component 2

2

2

High-throughput

0.628

High

1098600

GPS2
G protein pathway suppressor 2

2

3

High-throughput

0.611

High

480390

MMP7
Matrilysin

3

6

High-throughput

0.609

High

567995

PRG2
Bone marrow proteoglycan

3

11

High-throughput

0.609

High

1418263

RM04
Large ribosomal subunit protein uL4m

3

5

High-throughput

0.609

High

1380546

PIGT
GPI-anchor transamidase component PIGT

3

5

High-throughput

0.604

High

1451505

INSL6
Insulin-like peptide INSL6

3

5

High-throughput

0.604

High

245549

OPA1
Dynamin-like GTPase OPA1, mitochondrial

2

0

High-throughput

0.602

High

1309317

GID4
Glucose-induced degradation protein 4 homolog

2

9

High-throughput

0.601

High

1388507

ZMY19
Zinc finger MYND domain-containing protein 19

2

2

High-throughput

0.601

High

1393185

SFRP2
Secreted frizzled-related protein 2

2

3

High-throughput

0.601

High

1449492

EMIL3
EMILIN-3

2

6

High-throughput

0.601

High

1451496

TCAL9
Transcription elongation factor A protein-like 9

2

4

High-throughput

0.601

High

1451500

NISCH
Nischarin

2

1

High-throughput

0.601

High

845356

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

2

0

High-throughput

0.576

High

230671

PRIC3
Prickle planar cell polarity protein 3

2

5

High-throughput

0.574

High

278764

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

2

4

High-throughput

0.574

High

562766

BMP1
Bone morphogenetic protein 1

2

6

High-throughput

0.574

High

1340135

LIRB4
Leukocyte immunoglobulin-like receptor subfamily B member 4

2

4

High-throughput

0.574

High

1395085

JPH4
Junctophilin-4

2

3

High-throughput

0.574

High

1451502

PRG3
Proteoglycan 3

2

11

High-throughput

0.574

High

181183

AXIN1
Axin-1

2

3

Small-scale

0.571

High

584814

NDKA
Nucleoside diphosphate kinase A

2

4

High-throughput

0.571

High

971176

UBE2H
Ubiquitin-conjugating enzyme E2 H

2

15

High-throughput

0.571

High

1095059

DUS4
Dual specificity protein phosphatase 4

2

4

High-throughput

0.571

High

1350214

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

2

1

High-throughput

0.571

High

765069

CTNB1
Catenin beta-1

1

2

Small-scale

0.561

High

409619

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

2

4

High-throughput

0.558

High

1392999

CC120
Coiled-coil domain-containing protein 120

2

6

High-throughput

0.549

High

1430520

RM18
Large ribosomal subunit protein uL18m

2

5

High-throughput

0.549

High

61662

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.536

High

63046

POTEF
POTE ankyrin domain family member F

1

2

High-throughput

0.536

High

130262

PGRC1
Membrane-associated progesterone receptor component 1

1

2

High-throughput

0.536

High

169319

LECT2
Leukocyte cell-derived chemotaxin-2

1

4

High-throughput

0.536

High

253457

CST8
Cystatin-8

1

3

High-throughput

0.536

High

270278

MTG16
Protein CBFA2T3

1

4

High-throughput

0.536

High

342340

BRD1
Bromodomain-containing protein 1

1

4

High-throughput

0.536

High

440752

FYN
Tyrosine-protein kinase Fyn

1

2

High-throughput

0.536

High

457927

INVO
Involucrin

1

1

High-throughput

0.536

High

555434

SKI
Ski oncogene

1

3

High-throughput

0.536

High

721744

GCH1
GTP cyclohydrolase 1

1

4

High-throughput

0.536

High

729476

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

2

High-throughput

0.536

High

872804

SOX2
Transcription factor SOX-2

1

6

High-throughput

0.536

High

974064

RUXF
Small nuclear ribonucleoprotein F

1

2

High-throughput

0.536

High

1198324

TIGD5
Tigger transposable element-derived protein 5

1

3

High-throughput

0.536

High

1250859

CRDL2
Chordin-like protein 2

1

4

High-throughput

0.536

High

1314446

SLX4
Structure-specific endonuclease subunit SLX4

1

3

High-throughput

0.536

High

1335251

KCTD6
BTB/POZ domain-containing protein KCTD6

1

6

High-throughput

0.536

High

1408513

GDF15
Growth/differentiation factor 15

1

7

High-throughput

0.536

High

1409957

DDX50
ATP-dependent RNA helicase DDX50

1

9

High-throughput

0.536

High

1447964

ASH1L
Histone-lysine N-methyltransferase ASH1L

1

1

High-throughput

0.536

High

1451501

E41L3
Band 4.1-like protein 3

1

11

High-throughput

0.536

High

615201

PACA
Pituitary adenylate cyclase-activating polypeptide

2

4

High-throughput

0.521

High

1145402

RNPS1
RNA-binding protein with serine-rich domain 1

1

3

High-throughput

0.515

High

1208903

H2B2F
Histone H2B type 2-F

1

2

High-throughput

0.515

High

609341

SAP3
Ganglioside GM2 activator

1

0

High-throughput

0.513

High

649791

SPR2D
Small proline-rich protein 2D

1

0

High-throughput

0.513

High

1451493

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.513

High

316694

LY6H
Lymphocyte antigen 6H

1

3

High-throughput

0.489

High

377297

GLUC
Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide

1

5

High-throughput

0.489

High

477346

NMB
Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]

1

4

High-throughput

0.489

High

652680

GNLY
Granulysin

1

5

High-throughput

0.489

High

945757

ISK7
Serine protease inhibitor Kazal-type 7

1

1

High-throughput

0.489

High

1009734

NGAL
Neutrophil gelatinase-associated lipocalin

1

2

High-throughput

0.489

High

1206441

EFHC2
EF-hand domain-containing family member C2

1

4

High-throughput

0.489

High

1389224

RT24
Small ribosomal subunit protein uS3m

1

3

High-throughput

0.489

High

1412333

GDAH
Guanidino acid hydrolase, mitochondrial

1

2

High-throughput

0.489

High

1428801

WN10A
Protein Wnt-10a

1

5

High-throughput

0.489

High

1438804

SPON1
Spondin-1

1

6

High-throughput

0.489

High

1451495

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

6

High-throughput

0.489

High

1451497

MRM2
rRNA methyltransferase 2, mitochondrial

1

3

High-throughput

0.489

High

1451503

RT02
Small ribosomal subunit protein uS2m

1

2

High-throughput

0.489

High

1451504

COQ4
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial

1

3

High-throughput

0.489

High

159882

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

5

High-throughput

0.479

High

294417

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

316072

RECQ4
ATP-dependent DNA helicase Q4

1

10

High-throughput

0.479

High

891825

GSK3B
Glycogen synthase kinase-3 beta

1

1

Small-scale

0.479

High

956018

RAB8A
Ras-related protein Rab-8A

1

5

High-throughput

0.479

High

1049028

REL
Proto-oncogene c-Rel

1

3

High-throughput

0.479

High

1051325

KPCZ
Protein kinase C zeta type

1

4

High-throughput

0.479

High

1100455

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.479

High

1114446

CUL3
Cullin-3

1

5

High-throughput

0.479

High

1121348

TRI14
Tripartite motif-containing protein 14

1

2

High-throughput

0.479

High

1138691

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1163766

PTN21
Tyrosine-protein phosphatase non-receptor type 21

1

11

High-throughput

0.479

High

1255797

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

1280551

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

4

High-throughput

0.479

High

1391152

CHMP6
Charged multivesicular body protein 6

1

1

High-throughput

0.479

High

1414917

DUS26
Dual specificity protein phosphatase 26

1

4

High-throughput

0.479

High

1421266

RHG39
Rho GTPase-activating protein 39

1

2

High-throughput

0.479

High

1430074

RGAP1
Rac GTPase-activating protein 1

1

2

High-throughput

0.479

High

1435359

EGLN3
Prolyl hydroxylase EGLN3

1

4

High-throughput

0.479

High

447506

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

794644

RBMX
RNA-binding motif protein, X chromosome

1

0

High-throughput

0.458

High

855527

ATRX
Transcriptional regulator ATRX

1

0

High-throughput

0.458

High

1229711

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1252403

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.458

High

639174

SYT1
Synaptotagmin-1

1

6

High-throughput

0.445

High

786286

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.445

High

872037

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

4

High-throughput

0.445

High

1047875

TLE1
Transducin-like enhancer protein 1

1

3

High-throughput

0.445

High

1104685

IKZF1
DNA-binding protein Ikaros

1

4

High-throughput

0.445

High

1141424

WDR43
WD repeat-containing protein 43

1

1

High-throughput

0.445

High

1181504

EMAL3
Echinoderm microtubule-associated protein-like 3

1

4

High-throughput

0.445

High

1220139

PAPD7
Terminal nucleotidyltransferase 4A

1

2

High-throughput

0.445

High

1335393

CAMKV
CaM kinase-like vesicle-associated protein

1

2

High-throughput

0.445

High

1430724

OSBL5
Oxysterol-binding protein-related protein 5

1

1

High-throughput

0.445

High

460883

CATB
Cathepsin B

1

1

High-throughput

0.437

High

1451492

SPN90
NCK-interacting protein with SH3 domain

1

0

High-throughput

0.426

High

1194799

GRPL2
GLIPR1-like protein 2

1

4

High-throughput

0.407

High

1257232

NEK10
Serine/threonine-protein kinase Nek10

1

2

High-throughput

0.407

High

1324278

LYPD1
Ly6/PLAUR domain-containing protein 1

1

1

High-throughput

0.407

High

1331867

SYT2
Synaptotagmin-2

1

6

High-throughput

0.407

High

1401816

PEO1
Twinkle mtDNA helicase

1

3

High-throughput

0.407

High

1402428

HPLN3
Hyaluronan and proteoglycan link protein 3

1

5

High-throughput

0.407

High

1451494

EGFL7
Epidermal growth factor-like protein 7

1

2

High-throughput

0.407

High

773997

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.279

Low

933234

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.279

Low

1329590

NATD1
Protein NATD1

1

0

High-throughput

0.279

Low

1451498

PNMA2
Paraneoplastic antigen Ma2

1

0

High-throughput

0.279

Low

1256613

CE128
Centrosomal protein of 128 kDa

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025