HitPredict

Interactor 1: PRS10 (P53549)
26S proteasome subunit RPT4 (26S protease subunit SUG2) (Proteasomal cap subunit)
Gene: RPT4

Interactor 2: RPN8 (Q08723)
26S proteasome regulatory subunit RPN8
Gene: RPN8

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	16554755, 37968396
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	JAB~Prot_ATP_ID_OB, MitMem_reg~Prot_ATP_ID_OB
Common GO terms	GO:0000502 - proteasome complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 437 Sc			1 338
+	Dm
		640769 PRS4_DROME (27-428): 6.75e-136: 399: 37.99		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	At
		1320084 PRS4A_ARATH (19-428): 3e-135: 397: 37.74		PSD7B_ARATH (6-311): 1.9e-100: 300: 49.03
+	At
		188943 PRS4A_ARATH (19-428): 3e-135: 397: 37.74		PSD7A_ARATH (6-308): 6.55e-100: 298: 49.18
+	Hs
		849177 PRS8_HUMAN (43-437): 1.18e-135: 397: 41.29		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Dm
		640797 Q9W414_DROME (50-437): 3.69e-127: 375: 68.81		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Hs
		849179 PRS10_HUMAN (51-437): 1.51e-129: 381: 67.70		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Hs
		849176 PRS4_HUMAN (27-428): 6.56e-126: 373: 38.24		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Sc
		968091 PRS8_YEAST (73-437): 2.68e-99: 304: 44.89		RPN8_YEAST (1-338): 6.52e-119: 348: 100.00
+	Sc
		703971 PRS7_YEAST (116-436): 9.22e-93: 289: 46.89		RPN8_YEAST (1-338): 6.52e-119: 348: 100.00
+	Dm
		820501 PRS4_DROME (27-428): 6.75e-136: 399: 37.99		PSDE_DROME (3-264): 6.45e-48: 165: 16.90
+	Sp
		251475 PRS10_SCHPO (52-437): 2.31e-121: 360: 74.61		RPN11_SCHPO (1-263): 3.34e-61: 199: 19.11
+	At
		1339598 PRS4A_ARATH (19-428): 3e-135: 397: 37.74		PSDE_ARATH (3-263): 1.25e-46: 161: 17.65
+	Hs
		124808 TERA_HUMAN (23-433): 3.62e-79: 262: 26.83		EIF3F_HUMAN (4-294): 9.48e-93: 282: 26.03
+	Dm
		1358678 Q9W414_DROME (50-437): 3.69e-127: 375: 68.81		PSDE_DROME (3-264): 6.45e-48: 165: 16.90
+	Dm
		1181024 Q7KMQ0_DROME (114-422): 1.29e-92: 288: 47.90		PSDE_DROME (3-264): 6.45e-48: 165: 16.90
+	Dm
		186102 PRS8_DROME (1-147): 2.61e-09: 60.9: 9.32		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Dm
		640783 Q9V405_DROME (1-123): 2.61e-09: 60.9: 7.30		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Hs
		798615 PRS6B_HUMAN (1-123): 4.23e-09: 60.2: 8.03		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Dm
		1358669 Q9V405_DROME (1-123): 2.61e-09: 60.9: 7.30		PSDE_DROME (3-264): 6.45e-48: 165: 16.90
+	Dm
		186131 PRS8_DROME (1-147): 2.61e-09: 60.9: 9.32		PSDE_DROME (3-264): 6.45e-48: 165: 16.90