HitPredict

Interactor 1: RCAN1 (P53805)
Calcipressin-1 (Adapt78) (Down syndrome critical region protein 1) (Myocyte-enriched calcineurin-interacting protein 1) (MCIP1) (Regulator of calcineurin 1)
Gene: RCAN1

Interactor 2: CANB1 (P63098)
Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1)
Gene: PPP3R1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.678

Property	Details
Experiments	28514442, 33961781, 35914814
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, two hybrid fragment pooling approach
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008597 - calcium-dependent protein serine/threonine phosphatase regulator activity GO:0033173 - calcineurin-NFAT signaling cascade
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 252 Hs			1 170
+	Hs
		865114 RCAN1_HUMAN (1-252): 1.54e-148: 416: 100.00		CANB2_HUMAN (1-170): 5.69e-44: 144: 84.71
+	Hs
		483987 RCAN1_HUMAN (1-252): 1.54e-148: 416: 100.00		CALM2_HUMAN (86-159): 2.91e-10: 57.2: 27.03
+	Hs
		484089 RCAN1_HUMAN (1-252): 1.54e-148: 416: 100.00		CALM3_HUMAN (86-159): 2.91e-10: 57.2: 27.03
+	Hs
		926734 RCAN2_HUMAN (52-248): 1.9e-99: 290: 60.20		CANB1_HUMAN (1-170): 3.82e-49: 158: 100.00
+	Hs
		926759 RCAN3_HUMAN (57-252): 9.15e-98: 287: 59.00		CANB1_HUMAN (1-170): 3.82e-49: 158: 100.00
+	Dm
		1096818 SRA_DROME (55-245): 1.33e-71: 222: 39.38		CANB2_DROME (1-170): 2.22e-46: 151: 87.65
+	Dm
		906754 SRA_DROME (55-245): 1.33e-71: 222: 39.38		CALM_DROME (86-159): 3.94e-10: 56.8: 27.03