HitPredict

Interactor 1: BACE1 (P56817)
Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2)
Gene: BACE1

Interactor 2: GGA3 (Q9NZ52)
ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3)
Gene: GGA3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	26053850, 14567678
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005764 - lysosome GO:0005794 - Golgi apparatus GO:0005802 - trans-Golgi network GO:0010008 - endosome membrane
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 501 Hs			1 723
+	Hs
		882053 BACE1_HUMAN (1-501): 0: 520: 100.00		GGA1_HUMAN (2-723): 1.09e-91: 301: 39.78
+	Hs
		1356203 BACE2_HUMAN (34-467): 1.78e-116: 354: 49.31		GGA1_HUMAN (2-723): 1.09e-91: 301: 39.78
+	Hs
		882052 BACE1_HUMAN (1-501): 0: 520: 100.00		GGA2_HUMAN (456-721): 1.1e-25: 114: 34.83
+	Hs
		1356196 BACE2_HUMAN (34-467): 1.78e-116: 354: 49.31		GGA2_HUMAN (456-721): 1.1e-25: 114: 34.83