HitPredict

Interactor 1: RD23B (P54727)
UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58)
Gene: RAD23B

Interactor 2: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	27114451, 10488153
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~ubiquitin
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 409 Hs			1 406
+	Rn
		907221 RD23B_RAT (1-409): 1.14e-120: 358: 87.23		PRS8_RAT (1-406): 1.42e-136: 398: 100.00
+	Hs
		872248 RD23B_HUMAN (1-409): 1.31e-125: 370: 100.00		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Rn
		906973 RD23B_RAT (1-409): 1.14e-120: 358: 87.23		PRS4_RAT (4-396): 7.85e-130: 382: 46.31
+	Hs
		798621 RD23B_HUMAN (1-409): 1.31e-125: 370: 100.00		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Rn
		1117333 RD23B_RAT (1-409): 1.14e-120: 358: 87.23		PRS6B_RAT (1-399): 8.58e-122: 360: 41.86
+	Hs
		730225 RD23B_HUMAN (1-409): 1.31e-125: 370: 100.00		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Rn
		1117330 RD23B_RAT (1-409): 1.14e-120: 358: 87.23		PRS7_RAT (84-392): 1.59e-114: 343: 55.99
+	Hs
		872134 RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		872133 RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	At
		1352317 DSK2A_ARATH (1-407): 2.58e-59: 203: 17.08		PRS4A_ARATH (19-396): 1.25e-158: 455: 47.62
+	Hs
		798620 RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Dm
		1359291 Q9V3W9_DROME (1-408): 5.38e-89: 277: 36.75		Q9V405_DROME (7-399): 9.79e-122: 360: 41.73
+	Hs
		730224 RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Hs
		906946 UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Sc
		697067 RAD23_YEAST (1-407): 2.12e-72: 233: 28.41		PRS7_YEAST (84-391): 1.53e-111: 336: 54.87
+	Hs
		798782 UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		730383 UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Hs
		872250 RD23B_HUMAN (1-409): 1.31e-125: 370: 100.00		PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64
+	Rn
		1104198 RD23B_RAT (1-409): 1.14e-120: 358: 87.23		Q32PW9_RAT (8-101): 1.81e-10: 64: 10.64
+	Sc
		697108 RAD23_YEAST (1-407): 2.12e-72: 233: 28.41		PRS8_YEAST (8-110): 1.31e-09: 61.7: 7.77