HitPredict

Interactor 1: CASP7 (P55210)
Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
Gene: CASP7

Interactor 2: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.949

Property	Details
Experiments	33961781, 9384571, 19258326, 15580265, 16339151, 11084335
Identification Methods	affinity chromatography technology, pull down, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	BIR~Peptidase_C14
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006915 - apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 618
+	Hs
		788194 CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03		BIRC2_HUMAN (1-618): 0: 702: 100.00
+	Mm
		140026 CASP3_MOUSE (57-301): 2.37e-112: 327: 55.92		BIRC3_MOUSE (21-618): 0: 624: 66.28
+	Hs
		876944 CASP7_HUMAN (1-303): 2.97e-157: 442: 100.00		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Mm
		957027 CASP7_MOUSE (1-303): 3.09e-159: 447: 82.18		XIAP_MOUSE (20-173): 1.62e-31: 130: 28.66
+	Hs
		876960 CASP7_HUMAN (1-303): 2.97e-157: 442: 100.00		BIRC7_HUMAN (299-618): 4.32e-34: 133: 20.94
+	Hs
		876964 CASP7_HUMAN (1-303): 2.97e-157: 442: 100.00		BIRC6_HUMAN (34-167): 3.57e-31: 132: 19.42
+	Hs
		876939 CASP7_HUMAN (1-303): 2.97e-157: 442: 100.00		XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38
+	Hs
		177663 CASP7_HUMAN (1-303): 2.97e-157: 442: 100.00		BIRC5_HUMAN (267-346): 2.28e-22: 95.4: 34.12
+	Hs
		788193 CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		788183 CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03		MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56
+	Hs
		788221 CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03		BIRC7_HUMAN (299-618): 4.32e-34: 133: 20.94
+	Hs
		788230 CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03		BIRC6_HUMAN (34-167): 3.57e-31: 132: 19.42
+	Hs
		788182 CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03		XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38
+	Mm
		936913 CASP3_MOUSE (57-301): 2.37e-112: 327: 55.92		XIAP_MOUSE (20-173): 1.62e-31: 130: 28.66
+	Hs
		877014 CASP6_HUMAN (56-301): 5.33e-104: 307: 38.28		XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38
+	Hs
		177658 CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03		BIRC5_HUMAN (267-346): 2.28e-22: 95.4: 34.12
+	Rn
		1337442 Q9JHK1_RAT (53-301): 2.01e-97: 296: 31.66		XIAP_RAT (20-167): 1.35e-30: 127: 27.82
+	Dm
		136289 DRICE_DROME (33-302): 2.73e-108: 319: 43.02		DIAP1_DROME (35-174): 2.28e-22: 102: 23.57
+	Dm
		137119 CASP1_DROME (20-302): 1.17e-105: 312: 39.72		DIAP1_DROME (35-174): 2.28e-22: 102: 23.57
+	Dm
		136290 DRICE_DROME (33-302): 2.73e-108: 319: 43.02		DIAP2_DROME (261-462): 3.99e-12: 70.8: 16.99