HitPredict

Interactor 1: CASP9 (P55211)
Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]
Gene: CASP9

Interactor 2: BIRC1 (Q13075)
Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein)
Gene: NAIP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	15280366
Identification Methods	far western blotting
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	BIR~Peptidase_C14
Common GO terms	GO:0005737 - cytoplasm GO:0006915 - apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 416 Hs			1 1403
+	Hs
		667478 CASP1_HUMAN (10-413): 3.53e-121: 359: 23.45		NAL10_HUMAN (342-888): 1.74e-117: 384: 15.91
+	Mm
		140032 CASP9_MOUSE (1-416): 3.71e-164: 470: 71.81		BIRC3_MOUSE (1-263): 2.39e-58: 215: 24.83
+	Hs
		876981 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		BIRC2_HUMAN (1-264): 1.49e-57: 213: 25.25
+	Hs
		876980 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		BIRC3_HUMAN (1-264): 5.61e-57: 211: 26.40
+	Rn
		1337442 Q9JHK1_RAT (1-416): 8.46e-159: 457: 71.37		XIAP_RAT (2-131): 2.38e-40: 159: 21.54
+	Hs
		876972 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		XIAP_HUMAN (2-131): 5.72e-38: 151: 21.37
+	Hs
		876997 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		BIRC7_HUMAN (3-128): 4.73e-31: 126: 27.14
+	Hs
		788252 CASP2_HUMAN (1-413): 2.57e-123: 366: 28.18		BIRC2_HUMAN (1-264): 1.49e-57: 213: 25.25
+	Hs
		876987 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		Q6PIA0_HUMAN (57-131): 5.07e-25: 107: 33.33
+	Hs
		876998 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		BIRC8_HUMAN (57-131): 6.76e-25: 106: 33.33
+	Hs
		667461 CASP1_HUMAN (10-413): 3.53e-121: 359: 23.45		BIRC3_HUMAN (1-264): 5.61e-57: 211: 26.40
+	Hs
		877005 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		NOD1_HUMAN (1129-1333): 1.43e-20: 100: 20.19
+	Hs
		877001 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		NLRP1_HUMAN (1219-1389): 1.8e-13: 77.9: 21.26
+	Hs
		877004 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		BIRC6_HUMAN (57-136): 5.57e-12: 73.3: 32.94
+	Hs
		177664 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		BIRC5_HUMAN (63-127): 4.18e-10: 61.3: 32.86
+	Hs
		667484 CASP1_HUMAN (10-413): 3.53e-121: 359: 23.45		NLRP3_HUMAN (1060-1387): 4.25e-29: 128: 12.94
+	Hs
		788267 CASP2_HUMAN (1-413): 2.57e-123: 366: 28.18		NOD1_HUMAN (1129-1333): 1.43e-20: 100: 20.19
+	Hs
		667480 CASP1_HUMAN (10-413): 3.53e-121: 359: 23.45		NALP7_HUMAN (1059-1385): 1.91e-22: 106: 17.26
+	Hs
		788263 CASP2_HUMAN (1-413): 2.57e-123: 366: 28.18		NLRP1_HUMAN (1219-1389): 1.8e-13: 77.9: 21.26
+	Hs
		667448 CASP1_HUMAN (10-413): 3.53e-121: 359: 23.45		NLRP6_HUMAN (1184-1383): 3.18e-09: 63.7: 12.44