HitPredict

Interactor 1: SEC13 (P55735)
Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein)
Gene: SEC13

Interactor 2: PPWD1 (Q96BP3)
Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8) (Spliceosome-associated cyclophilin)
Gene: PPWD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 322 Hs			1 646
+	Hs
		1285812 SNR40_HUMAN (3-131): 4.97e-25: 104: 22.22		PPWD1_HUMAN (1-646): 0: 602: 100.00
+	Hs
		878165 SEC13_HUMAN (1-322): 1.89e-85: 261: 100.00		WDR5_HUMAN (175-406): 3.52e-49: 176: 13.77
+	Hs
		1032301 SNR40_HUMAN (3-131): 4.97e-25: 104: 22.22		PPIL2_HUMAN (382-645): 1.78e-83: 273: 31.96
+	Dm
		1358845 WDS_DROME (90-319): 1.09e-47: 165: 19.57		WDS_DROME (68-311): 1.6e-52: 186: 12.40
+	Hs
		1240442 POC1A_HUMAN (5-132): 1.69e-26: 109: 20.31		POC1B_HUMAN (119-484): 1.09e-65: 225: 11.52
+	Hs
		903418 FBXW7_HUMAN (87-316): 1.49e-41: 154: 14.72		WDR5_HUMAN (175-406): 3.52e-49: 176: 13.77
+	Hs
		614291 WDR5_HUMAN (249-320): 1.4e-10: 63.3: 16.67		PPIB_HUMAN (473-644): 3.84e-74: 238: 44.32
+	Hs
		903349 WDR5B_HUMAN (2-194): 1.22e-31: 122: 16.67		WDR5_HUMAN (175-406): 3.52e-49: 176: 13.77
+	Hs
		903551 NLE1_HUMAN (196-317): 5.64e-28: 114: 20.49		WDR5_HUMAN (175-406): 3.52e-49: 176: 13.77
+	Hs
		903428 SNR40_HUMAN (3-131): 4.97e-25: 104: 22.22		WDR5_HUMAN (175-406): 3.52e-49: 176: 13.77
+	Hs
		792949 LIS1_HUMAN (208-320): 5.26e-24: 102: 20.35		WDR5_HUMAN (175-406): 3.52e-49: 176: 13.77
+	Hs
		903077 WDR5_HUMAN (249-320): 1.4e-10: 63.3: 16.67		WDR5_HUMAN (175-406): 3.52e-49: 176: 13.77
+	Hs
		282871 CIAO1_HUMAN (12-93): 1.73e-09: 60: 28.09		WDR5_HUMAN (175-406): 3.52e-49: 176: 13.77
+	Hs
		903431 SEH1_HUMAN (15-180): 2.01e-09: 60: 18.75		WDR5_HUMAN (175-406): 3.52e-49: 176: 13.77