HitPredict

Interactor 1: SUMO3 (P55854)
Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A)
Gene: SUMO3

Interactor 2: PIAS3 (Q9Y6X2)
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)
Gene: PIAS3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	16524884
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Rad60-SLD~zf-MIZ
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016925 - protein sumoylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 103 Hs			1 628
+	Hs
		902827 SUMO2_HUMAN (1-93): 4.15e-41: 132: 96.81		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		928241 SUMO1_HUMAN (1-92): 2.47e-36: 120: 48.45		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Mm
		222291 SUMO1_MOUSE (1-92): 2.47e-36: 120: 48.45		PIAS3_MOUSE (1-628): 0: 867: 96.98
+	Hs
		278009 SUMO3_HUMAN (1-103): 1.24e-48: 151: 100.00		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278020 SUMO2_HUMAN (1-93): 4.15e-41: 132: 96.81		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278040 SUMO1_HUMAN (1-92): 2.47e-36: 120: 48.45		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278250 SUMO3_HUMAN (1-103): 1.24e-48: 151: 100.00		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		278253 SUMO2_HUMAN (1-93): 4.15e-41: 132: 96.81		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		278256 SUMO1_HUMAN (1-92): 2.47e-36: 120: 48.45		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Rn
		1140374 SUMO3_RAT (1-97): 6.47e-45: 142: 94.85		PIAS2_RAT (1-528): 0: 626: 59.71
+	Hs
		879136 SUMO3_HUMAN (1-103): 1.24e-48: 151: 100.00		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71
+	Rn
		78200 SUMO3_RAT (1-97): 6.47e-45: 142: 94.85		B5DFF9_RAT (2-443): 7.68e-174: 505: 50.45
+	Hs
		902668 SUMO2_HUMAN (1-93): 4.15e-41: 132: 96.81		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71
+	Hs
		928135 SUMO1_HUMAN (1-92): 2.47e-36: 120: 48.45		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71
+	Rn
		78199 SUMO1_RAT (1-92): 2.47e-36: 120: 48.45		B5DFF9_RAT (2-443): 7.68e-174: 505: 50.45
+	Dm
		332592 O97102_DROME (6-94): 4.45e-39: 127: 69.66		Q9XYM5_DROME (10-519): 2.07e-161: 474: 42.34
+	At
		1147334 SUMO2_ARATH (1-98): 1.43e-41: 133: 47.96		SIZ1_ARATH (5-623): 1.75e-120: 380: 21.29
+	At
		1147333 SUMO3_ARATH (1-96): 2.22e-37: 123: 40.21		SIZ1_ARATH (5-623): 1.75e-120: 380: 21.29
+	At
		878961 SUMO1_ARATH (2-90): 1.01e-35: 118: 47.19		SIZ1_ARATH (5-623): 1.75e-120: 380: 21.29
+	Rn
		89025 SUMO3_RAT (1-97): 6.47e-45: 142: 94.85		D4AE97_RAT (79-422): 2.72e-84: 287: 24.93