HitPredict

Interactor 1: HDAC4 (P56524)
Histone deacetylase 4 (HD4) (EC 3.5.1.98)
Gene: HDAC4

Interactor 2: NCOR2 (Q9Y618)
Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)
Gene: NCOR2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.924

Property	Details
Experiments	27684187, 11804585, 10640275, 31040226, 12205093
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Hist_deacetyl~Myb_DNA-binding
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0017053 - transcription repressor complex and 1 others more... GO:0042826 - histone deacetylase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1084 Hs			1 2514
+	Hs
		1357907 HDAC5_HUMAN (1-1084): 0: 785: 55.67		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		1260208 HDAC7_HUMAN (57-1084): 0: 679: 46.36		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Mm
		1112790 Q3UJF1_MOUSE (2-1084): 0: 783: 55.84		NCOR2_MOUSE (1-2514): 0: 760: 82.56
+	Hs
		261452 HDAC4_HUMAN (1-1072): 0: 974: 100.00		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Mm
		1207909 HDAC7_MOUSE (39-1084): 0: 645: 44.47		NCOR2_MOUSE (1-2514): 0: 760: 82.56
+	Hs
		261611 HDAC9_HUMAN (25-1025): 0: 797: 56.25		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		261614 HDAC5_HUMAN (1-1084): 0: 785: 55.67		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		261554 HDAC7_HUMAN (57-1084): 0: 679: 46.36		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		880756 HDAC4_HUMAN (1-1072): 0: 974: 100.00		MAP1S_HUMAN (677-1123): 3.28e-13: 77.7: 15.77
+	Mm
		1111987 HDAC4_MOUSE (1-1072): 0: 941: 93.66		PRC2C_MOUSE (778-2509): 8e-10: 66.9: 8.43
+	Mm
		1157748 HDAC4_MOUSE (1-1072): 0: 941: 93.66		SYNJ1_MOUSE (939-1442): 9.57e-10: 66.7: 9.63
+	Mm
		88461 HDAC4_MOUSE (1-1072): 0: 941: 93.66		D3Z656_MOUSE (1002-1442): 1.13e-09: 66.3: 12.66
+	Hs
		1356495 HDAC5_HUMAN (1-1084): 0: 785: 55.67		RCOR1_HUMAN (388-705): 2.51e-45: 174: 22.05
+	Hs
		261500 HDAC1_HUMAN (646-1080): 2.95e-163: 492: 21.68		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		1038521 HDAC1_HUMAN (646-1080): 2.95e-163: 492: 21.68		RCOR2_HUMAN (407-823): 1.19e-54: 203: 19.26
+	Mm
		140301 HDAC1_MOUSE (646-1080): 3.14e-163: 492: 21.46		RCOR1_MOUSE (378-704): 1.76e-42: 166: 22.35
+	Hs
		1038768 HDAC1_HUMAN (646-1080): 2.95e-163: 492: 21.68		RCOR3_HUMAN (351-810): 1.25e-41: 163: 20.65
+	Hs
		1038652 HDAC1_HUMAN (646-1080): 2.95e-163: 492: 21.68		MINT_HUMAN (80-1321): 6.8e-20: 100: 8.11
+	Hs
		1038645 HDAC1_HUMAN (646-1080): 2.95e-163: 492: 21.68		CIC_HUMAN (7-2131): 8.47e-18: 93.5: 9.33
+	Hs
		203227 HDAC1_HUMAN (646-1080): 2.95e-163: 492: 21.68		SYNJ1_HUMAN (1420-1892): 5.37e-09: 64.4: 11.18