HitPredict

Interactor 1: MTR1B (P49286)
Melatonin receptor type 1B (Mel-1B-R) (Mel1b receptor)
Gene: MTNR1B

Interactor 2: GBB4 (Q9HAV0)
Guanine nucleotide-binding protein subunit beta-4 (Transducin beta chain 4)
Gene: GNB4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26514267, 17215244
Identification Methods	pull down, tandem affinity purification
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007186 - G protein-coupled receptor signaling pathway GO:0045202 - synapse
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 362 Hs			1 340
+	Hs
		880900 MTR1B_HUMAN (1-362): 1.1e-80: 252: 100.00		GBB2_HUMAN (1-340): 8.23e-110: 325: 90.00
+	Hs
		458367 ADRB2_HUMAN (1-347): 5.58e-75: 239: 17.55		GBB2_HUMAN (1-340): 8.23e-110: 325: 90.00
+	Hs
		458490 ADRB2_HUMAN (1-347): 5.58e-75: 239: 17.55		GBB4_HUMAN (1-340): 1.1e-109: 324: 100.00
+	Hs
		458366 ADRB2_HUMAN (1-347): 5.58e-75: 239: 17.55		GBB1_HUMAN (1-340): 6.08e-106: 315: 90.88
+	Hs
		869792 MTR1A_HUMAN (8-350): 1.44e-71: 228: 59.77		GBB4_HUMAN (1-340): 1.1e-109: 324: 100.00
+	Hs
		869720 MTR1A_HUMAN (8-350): 1.44e-71: 228: 59.77		GBB1_HUMAN (1-340): 6.08e-106: 315: 90.88
+	Rn
		528538 ADRB2_RAT (20-341): 1.56e-74: 238: 19.66		GNB5_RAT (129-340): 3.88e-42: 151: 23.08