Protein: MTR1B
Melatonin receptor type 1B (Mel-1B-R) (Mel1b receptor)

Gene: MTR1B, MTNR1B
Organism: Homo sapiens
Interactions: 141
UniProt ID: P49286

Gene Ontology (top 5):
GO:0004930 - G protein-coupled receptor activity
GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0007187 - G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007268 - chemical synaptic transmission

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

880902

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

2

19

Small-scale

0.819

High

418621

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

2

19

Small-scale

0.789

High

475919

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

2

19

Small-scale

0.789

High

880922

PDIA6
Protein disulfide-isomerase A6

2

4

Small-scale

0.789

High

880895

COPA
Coatomer subunit alpha

2

0

Small-scale

0.660

High

880901

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

18

High-throughput

0.656

High

869709

MTR1A
Melatonin receptor type 1A

1

17

Small-scale

0.646

High

702751

5HT2C
5-hydroxytryptamine receptor 2C

1

16

Small-scale

0.618

High

880914

MTR1L
Melatonin-related receptor

1

19

Small-scale

0.618

High

637397

FLNA
Filamin-A

2

11

Small-scale

0.614

High

160444

IRS4
Insulin receptor substrate 4

2

1

Small-scale

0.611

High

534783

BIP
Endoplasmic reticulum chaperone BiP

2

2

Small-scale

0.611

High

690825

1433T
14-3-3 protein theta

2

9

Small-scale

0.611

High

880900

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

2

7

Small-scale

0.611

High

880967

GBB4
Guanine nucleotide-binding protein subunit beta-4

2

7

Small-scale

0.611

High

717403

PDIA3
Protein disulfide-isomerase A3

1

4

High-throughput

0.587

High

880942

DMXL2
DmX-like protein 2

1

9

High-throughput

0.587

High

880964

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

1

High-throughput

0.587

High

880969

ITM2C
Integral membrane protein 2C

2

0

Small-scale

0.585

High

698487

CALX
Calnexin

2

5

Small-scale

0.558

High

880952

VPS35
Vacuolar protein sorting-associated protein 35

2

1

Small-scale

0.558

High

839440

PI4KA
Phosphatidylinositol 4-kinase alpha

2

8

Small-scale

0.552

High

538830

GTR3
Solute carrier family 2, facilitated glucose transporter member 3

1

1

High-throughput

0.541

High

658870

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

3

High-throughput

0.541

High

880913

GPM6B
Neuronal membrane glycoprotein M6-b

1

1

High-throughput

0.541

High

880953

VATO
V-type proton ATPase 21 kDa proteolipid subunit c''

1

2

High-throughput

0.541

High

880977

GGT7
Glutathione hydrolase 7

1

1

High-throughput

0.541

High

880980

PCDBA
Protocadherin beta-10

1

2

High-throughput

0.541

High

521248

ARAF
Serine/threonine-protein kinase A-Raf

2

2

High-throughput

0.521

High

467409

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.518

High

243792

ADCY3
Adenylate cyclase type 3

1

1

High-throughput

0.508

High

466010

ANXA6
Annexin A6

1

2

High-throughput

0.508

High

469669

MMP2
72 kDa type IV collagenase

1

5

High-throughput

0.508

High

555634

ACTN1
Alpha-actinin-1

1

4

High-throughput

0.508

High

571123

CD99
CD99 antigen

1

1

High-throughput

0.508

High

764275

CTNA1
Catenin alpha-1

1

2

High-throughput

0.508

High

787536

TNR3
Tumor necrosis factor receptor superfamily member 3

1

2

High-throughput

0.508

High

787847

SRBP1
Sterol regulatory element-binding protein 1

1

4

High-throughput

0.508

High

880897

CADH4
Cadherin-4

1

5

High-throughput

0.508

High

880898

CAD11
Cadherin-11

1

3

High-throughput

0.508

High

880899

CAD13
Cadherin-13

1

10

High-throughput

0.508

High

880906

RHG01
Rho GTPase-activating protein 1

1

3

High-throughput

0.508

High

880912

S39A6
Zinc transporter ZIP6

1

6

High-throughput

0.508

High

880915

CUL3
Cullin-3

1

3

High-throughput

0.508

High

880919

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

1

High-throughput

0.508

High

880928

UBR4
E3 ubiquitin-protein ligase UBR4

1

2

High-throughput

0.508

High

880940

DYHC2
Cytoplasmic dynein 2 heavy chain 1

1

1

High-throughput

0.508

High

880965

EVA1A
Protein eva-1 homolog A

1

1

High-throughput

0.508

High

880976

UBQL2
Ubiquilin-2

1

3

High-throughput

0.508

High

880982

S12A4
Solute carrier family 12 member 4

1

5

High-throughput

0.508

High

880984

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

9

High-throughput

0.508

High

880988

TLN1
Talin-1

1

6

High-throughput

0.508

High

880992

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

3

High-throughput

0.508

High

880993

S4A7
Sodium bicarbonate cotransporter 3

1

1

High-throughput

0.508

High

303116

RGS20
Regulator of G-protein signaling 20

1

10

Small-scale

0.500

High

533256

THA
Thyroid hormone receptor alpha

1

1

High-throughput

0.494

High

729676

1433B
14-3-3 protein beta/alpha

1

9

High-throughput

0.494

High

880923

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

1

High-throughput

0.494

High

880938

I2BP2
Interferon regulatory factor 2-binding protein 2

1

2

High-throughput

0.494

High

880945

TM230
Transmembrane protein 230

1

2

High-throughput

0.494

High

880959

PIP30
PSME3-interacting protein

1

1

High-throughput

0.494

High

880960

MFF
Mitochondrial fission factor

1

1

High-throughput

0.494

High

880963

RNF41
E3 ubiquitin-protein ligase NRDP1

1

4

High-throughput

0.494

High

880973

DISP3
Protein dispatched homolog 3

1

2

High-throughput

0.494

High

880991

TM14A
Transmembrane protein 14A

1

1

High-throughput

0.494

High

352010

RECK
Reversion-inducing cysteine-rich protein with Kazal motifs

1

0

High-throughput

0.486

High

880905

B2CL1
Bcl-2-like protein 1

1

0

High-throughput

0.486

High

880924

ACKR1
Atypical chemokine receptor 1

1

19

High-throughput

0.481

High

180748

TIF1A
Transcription intermediary factor 1-alpha

1

3

High-throughput

0.464

High

246282

MARH6
E3 ubiquitin-protein ligase MARCHF6

1

1

High-throughput

0.464

High

272627

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

2

High-throughput

0.464

High

880896

XPO2
Exportin-2

1

10

High-throughput

0.464

High

880903

PRKDC
DNA-dependent protein kinase catalytic subunit

1

9

High-throughput

0.464

High

880904

DYST
Dystonin

1

9

High-throughput

0.464

High

880907

AP1B1
AP-1 complex subunit beta-1

1

2

High-throughput

0.464

High

880908

SRBP2
Sterol regulatory element-binding protein 2

1

3

High-throughput

0.464

High

880909

FSTL1
Follistatin-related protein 1

1

3

High-throughput

0.464

High

880911

CDC16
Cell division cycle protein 16 homolog

1

1

High-throughput

0.464

High

880916

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

3

High-throughput

0.464

High

880917

UBP2L
Ubiquitin-associated protein 2-like

1

3

High-throughput

0.464

High

880918

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

High-throughput

0.464

High

880920

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

6

High-throughput

0.464

High

880927

TGO1
Transport and Golgi organization protein 1 homolog

1

1

High-throughput

0.464

High

880929

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

1

High-throughput

0.464

High

880934

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

1

3

High-throughput

0.464

High

880935

MON2
Protein MON2 homolog

1

6

High-throughput

0.464

High

880936

CLAP1
CLIP-associating protein 1

1

7

High-throughput

0.464

High

880937

TRI46
Tripartite motif-containing protein 46

1

2

High-throughput

0.464

High

880939

INT1
Integrator complex subunit 1

1

5

High-throughput

0.464

High

880941

KMT2C
Histone-lysine N-methyltransferase 2C

1

2

High-throughput

0.464

High

880943

IPO4
Importin-4

1

2

High-throughput

0.464

High

880944

SYNE2
Nesprin-2

1

10

High-throughput

0.464

High

880947

RN185
E3 ubiquitin-protein ligase RNF185

1

5

High-throughput

0.464

High

880949

CREL1
Protein disulfide isomerase CRELD1

1

3

High-throughput

0.464

High

880950

COG8
Conserved oligomeric Golgi complex subunit 8

1

1

High-throughput

0.464

High

880951

IPO9
Importin-9

1

8

High-throughput

0.464

High

880961

BTBD1
BTB/POZ domain-containing protein 1

1

4

High-throughput

0.464

High

880966

COG4
Conserved oligomeric Golgi complex subunit 4

1

3

High-throughput

0.464

High

880968

PIDD1
p53-induced death domain-containing protein 1

1

2

High-throughput

0.464

High

880970

UBQL4
Ubiquilin-4

1

3

High-throughput

0.464

High

880979

HECD1
E3 ubiquitin-protein ligase HECTD1

1

5

High-throughput

0.464

High

880983

AP4E1
AP-4 complex subunit epsilon-1

1

3

High-throughput

0.464

High

880994

COX11
Cytochrome c oxidase assembly protein COX11, mitochondrial

1

1

High-throughput

0.464

High

132705

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

0

Small-scale

0.458

High

880925

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

7

High-throughput

0.457

High

880926

Q4VBN9
Atypical chemokine receptor 1

1

19

High-throughput

0.457

High

254082

CTND1
Catenin delta-1

1

5

High-throughput

0.445

High

880930

Q60FE5
Filamin A

1

14

High-throughput

0.445

High

76486

B4DXL2
cDNA FLJ58638, highly similar to Homo sapiens Rho GTPase activating protein 28

1

7

High-throughput

0.439

High

880978

ERG28
Ergosterol biosynthetic protein 28 homolog

1

1

High-throughput

0.439

High

880932

Q6FII3
C14orf1 protein

1

1

High-throughput

0.417

High

880974

RHG28
Rho GTPase-activating protein 28

1

8

High-throughput

0.417

High

187027

PPM1G
Protein phosphatase 1G

2

0

Small-scale

0.319

High

155393

DHSD
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

1

0

High-throughput

0.282

High

880962

STMN4
Stathmin-4

1

0

High-throughput

0.282

High

880972

CLDN1
Claudin domain-containing protein 1

1

0

High-throughput

0.282

High

880981

POLI
DNA polymerase iota

1

0

High-throughput

0.282

High

391202

FRIL
Ferritin light chain

1

0

High-throughput

0.265

Low

551697

HARS1
Histidine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.265

Low

608961

XBP1
X-box-binding protein 1

1

0

High-throughput

0.265

Low

733102

OTX1
Homeobox protein OTX1

1

0

High-throughput

0.265

Low

874126

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

0

High-throughput

0.265

Low

880910

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.265

Low

880921

ESPL1
Separin

1

0

High-throughput

0.265

Low

880931

PCX4
Pecanex-like protein 4

1

0

High-throughput

0.265

Low

880933

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.265

Low

880946

THOC1
THO complex subunit 1

1

0

High-throughput

0.265

Low

880948

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

High-throughput

0.265

Low

880954

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.265

Low

880955

TBCD
Tubulin-specific chaperone D

1

0

High-throughput

0.265

Low

880956

APOL6
Apolipoprotein L6

1

0

High-throughput

0.265

Low

880957

B2L13
Bcl-2-like protein 13

1

0

High-throughput

0.265

Low

880958

TNG6
Transport and Golgi organization protein 6 homolog

1

0

High-throughput

0.265

Low

880971

FANCI
Fanconi anemia group I protein

1

0

High-throughput

0.265

Low

880975

COE1
Transcription factor COE1

1

0

High-throughput

0.265

Low

880985

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

0

High-throughput

0.265

Low

880986

SMC3
Structural maintenance of chromosomes protein 3

1

0

High-throughput

0.265

Low

880987

MTMR6
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6

1

0

High-throughput

0.265

Low

880989

MARF1
Meiosis regulator and mRNA stability factor 1

1

0

High-throughput

0.265

Low

880990

RIPR2
Rho family-interacting cell polarization regulator 2

1

0

High-throughput

0.265

Low

94857

E1B2J3
Methyl-CpG-binding protein 2

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025