Protein: MTR1A
Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor)

Gene: MTR1A, MTNR1A
Organism: Homo sapiens
Interactions: 172
UniProt ID: P48039

Gene Ontology (top 5):
GO:0004930 - G protein-coupled receptor activity
GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0007187 - G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007193 - adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

418618

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

3

20

Small-scale

0.866

High

475916

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

3

20

Small-scale

0.866

High

869722

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

2

20

Small-scale

0.819

High

869747

PDIA6
Protein disulfide-isomerase A6

2

4

Small-scale

0.819

High

697797

CALR
Calreticulin

3

5

Small-scale

0.680

High

869709

MTR1B
Melatonin receptor type 1B

1

17

Small-scale

0.646

High

130033

PGRC1
Membrane-associated progesterone receptor component 1

2

1

Small-scale

0.634

High

160443

IRS4
Insulin receptor substrate 4

2

1

Small-scale

0.634

High

332910

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

5

Small-scale

0.634

High

869717

RAB10
Ras-related protein Rab-10

2

2

Small-scale

0.634

High

869721

RAC1
Ras-related C3 botulinum toxin substrate 1

2

2

Small-scale

0.634

High

869792

GBB4
Guanine nucleotide-binding protein subunit beta-4

2

8

Small-scale

0.634

High

869724

RACK1
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.625

High

869714

TMM33
Transmembrane protein 33

3

1

Small-scale

0.621

High

637394

FLNA
Filamin-A

2

12

Small-scale

0.620

High

702749

5HT2C
5-hydroxytryptamine receptor 2C

1

15

Small-scale

0.618

High

715997

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

20

Small-scale

0.618

High

869733

MTR1L
Melatonin-related receptor

1

19

Small-scale

0.618

High

534771

BIP
Endoplasmic reticulum chaperone BiP

2

2

Small-scale

0.601

High

869719

RAP1A
Ras-related protein Rap-1A

2

6

Small-scale

0.601

High

869720

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

2

8

Small-scale

0.601

High

157081

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.587

High

869812

TMX2
Thioredoxin-related transmembrane protein 2

1

0

High-throughput

0.584

High

687924

EF1G
Elongation factor 1-gamma

2

2

Small-scale

0.579

High

698472

CALX
Calnexin

2

5

Small-scale

0.579

High

869730

ROA0
Heterogeneous nuclear ribonucleoprotein A0

2

1

Small-scale

0.579

High

869778

LRC59
Leucine-rich repeat-containing protein 59

2

2

Small-scale

0.579

High

303114

RGS20
Regulator of G-protein signaling 20

1

10

Small-scale

0.561

High

869766

KRA13
Keratin-associated protein 1-3

2

2

High-throughput

0.553

High

869755

Q60FE5
Filamin A

2

15

Small-scale

0.552

High

270145

LRP3
Low-density lipoprotein receptor-related protein 3

1

1

High-throughput

0.541

High

408726

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.541

High

538829

GTR3
Solute carrier family 2, facilitated glucose transporter member 3

1

1

High-throughput

0.541

High

658865

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

3

High-throughput

0.541

High

719876

HMOX2
Heme oxygenase 2

1

3

High-throughput

0.541

High

776284

SOX11
Transcription factor SOX-11

1

1

High-throughput

0.541

High

869726

SC6A3
Sodium-dependent dopamine transporter

1

4

High-throughput

0.541

High

869772

LPP
Lipoma-preferred partner

1

1

High-throughput

0.541

High

869806

PCDBA
Protocadherin beta-10

1

2

High-throughput

0.541

High

184406

SURF4
Surfeit locus protein 4

1

0

High-throughput

0.518

High

642208

COMT
Catechol O-methyltransferase

1

0

High-throughput

0.518

High

659397

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.518

High

869725

CAC1B
Voltage-dependent N-type calcium channel subunit alpha-1B

1

1

High-throughput

0.515

High

168036

RGS12
Regulator of G-protein signaling 12

1

11

High-throughput

0.508

High

299751

MPDZ
Multiple PDZ domain protein

1

20

High-throughput

0.508

High

389146

FINC
Fibronectin

1

8

High-throughput

0.508

High

469668

MMP2
72 kDa type IV collagenase

1

5

High-throughput

0.508

High

555633

ACTN1
Alpha-actinin-1

1

4

High-throughput

0.508

High

571122

CD99
CD99 antigen

1

1

High-throughput

0.508

High

764273

CTNA1
Catenin alpha-1

1

2

High-throughput

0.508

High

839714

EPS15
Epidermal growth factor receptor substrate 15

1

4

High-throughput

0.508

High

844178

ECE1
Endothelin-converting enzyme 1

1

1

High-throughput

0.508

High

869716

ACTB
Actin, cytoplasmic 1

1

5

High-throughput

0.508

High

869718

STXB1
Syntaxin-binding protein 1

1

1

High-throughput

0.508

High

869729

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

8

High-throughput

0.508

High

869734

CUL3
Cullin-3

1

4

High-throughput

0.508

High

869738

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

1

High-throughput

0.508

High

869754

UBR4
E3 ubiquitin-protein ligase UBR4

1

2

High-throughput

0.508

High

869797

EXOC1
Exocyst complex component 1

1

1

High-throughput

0.508

High

869805

UBQL1
Ubiquilin-1

1

3

High-throughput

0.508

High

869809

AMOL2
Angiomotin-like protein 2

1

1

High-throughput

0.508

High

869814

TLN1
Talin-1

1

7

High-throughput

0.508

High

869816

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

3

High-throughput

0.508

High

186412

TM9S1
Transmembrane 9 superfamily member 1

1

4

High-throughput

0.494

High

457302

TBB5
Tubulin beta chain

1

6

High-throughput

0.494

High

729674

1433B
14-3-3 protein beta/alpha

1

8

High-throughput

0.494

High

869728

FSTL1
Follistatin-related protein 1

1

5

High-throughput

0.494

High

869765

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

13

High-throughput

0.494

High

869773

H2A1C
Histone H2A type 1-C

1

2

High-throughput

0.494

High

869776

ZDH16
Palmitoyltransferase ZDHHC16

1

4

High-throughput

0.494

High

869777

TM230
Transmembrane protein 230

1

2

High-throughput

0.494

High

869779

F241B
Protein FAM241B

1

2

High-throughput

0.494

High

869782

NP1L5
Nucleosome assembly protein 1-like 5

1

2

High-throughput

0.494

High

869791

RNF41
E3 ubiquitin-protein ligase NRDP1

1

4

High-throughput

0.494

High

869795

PYRG2
CTP synthase 2

1

1

High-throughput

0.494

High

869798

TV23B
Golgi apparatus membrane protein TVP23 homolog B

1

2

High-throughput

0.494

High

869799

CC167
Coiled-coil domain-containing protein 167

1

1

High-throughput

0.494

High

869815

TM14A
Transmembrane protein 14A

1

1

High-throughput

0.494

High

479121

ENOG
Gamma-enolase

1

0

High-throughput

0.486

High

728929

PUR9
Bifunctional purine biosynthesis protein ATIC

1

0

High-throughput

0.486

High

869741

MESD
LRP chaperone MESD

1

0

High-throughput

0.486

High

869793

GBA2
Non-lysosomal glucosylceramidase

1

0

High-throughput

0.486

High

869784

KLHL5
Kelch-like protein 5

1

3

High-throughput

0.481

High

270494

SLIT1
Slit homolog 1 protein

1

1

High-throughput

0.464

High

317445

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

1

1

High-throughput

0.464

High

647499

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

1

High-throughput

0.464

High

683717

PTX3
Pentraxin-related protein PTX3

1

3

High-throughput

0.464

High

687761

SYVC
Valine--tRNA ligase

1

2

High-throughput

0.464

High

709106

TPP2
Tripeptidyl-peptidase 2

1

1

High-throughput

0.464

High

721144

SORCN
Sorcin

1

4

High-throughput

0.464

High

729173

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

3

High-throughput

0.464

High

756538

GALNS
N-acetylgalactosamine-6-sulfatase

1

2

High-throughput

0.464

High

856581

BAG6
Large proline-rich protein BAG6

1

4

High-throughput

0.464

High

869710

NASP
Nuclear autoantigenic sperm protein

1

2

High-throughput

0.464

High

869712

ASCL1
Achaete-scute homolog 1

1

1

High-throughput

0.464

High

869713

NP1L1
Nucleosome assembly protein 1-like 1

1

1

High-throughput

0.464

High

869723

1433Z
14-3-3 protein zeta/delta

1

8

High-throughput

0.464

High

869731

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

High-throughput

0.464

High

869736

UBP2L
Ubiquitin-associated protein 2-like

1

3

High-throughput

0.464

High

869739

ZN460
Zinc finger protein 460

1

1

High-throughput

0.464

High

869740

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

6

High-throughput

0.464

High

869743

IMB1
Importin subunit beta-1

1

3

High-throughput

0.464

High

869750

SVEP1
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

1

3

High-throughput

0.464

High

869751

KLH12
Kelch-like protein 12

1

3

High-throughput

0.464

High

869759

ANR12
Ankyrin repeat domain-containing protein 12

1

1

High-throughput

0.464

High

869760

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.464

High

869761

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

1

4

High-throughput

0.464

High

869762

PK1L2
Polycystin-1-like protein 2

1

6

High-throughput

0.464

High

869763

CLAP1
CLIP-associating protein 1

1

8

High-throughput

0.464

High

869768

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

6

High-throughput

0.464

High

869769

ASAP3
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

1

1

High-throughput

0.464

High

869770

COG1
Conserved oligomeric Golgi complex subunit 1

1

1

High-throughput

0.464

High

869775

HDA10
Polyamine deacetylase HDAC10

1

1

High-throughput

0.464

High

869783

IPO9
Importin-9

1

11

High-throughput

0.464

High

869785

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

6

High-throughput

0.464

High

869786

MMS19
MMS19 nucleotide excision repair protein homolog

1

1

High-throughput

0.464

High

869787

RING2
E3 ubiquitin-protein ligase RING2

1

1

High-throughput

0.464

High

869788

NP1L4
Nucleosome assembly protein 1-like 4

1

2

High-throughput

0.464

High

869796

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

3

High-throughput

0.464

High

869802

BAZ1B
Tyrosine-protein kinase BAZ1B

1

3

High-throughput

0.464

High

869810

KLH20
Kelch-like protein 20

1

3

High-throughput

0.464

High

869817

COX11
Cytochrome c oxidase assembly protein COX11, mitochondrial

1

1

High-throughput

0.464

High

516910

EFCE2
EEF1AKMT4-ECE2 readthrough transcript protein

1

2

High-throughput

0.457

High

76485

B4DXL2
cDNA FLJ58638, highly similar to Homo sapiens Rho GTPase activating protein 28

1

9

High-throughput

0.439

High

649872

ADRO
NADPH:adrenodoxin oxidoreductase, mitochondrial

1

2

High-throughput

0.439

High

809963

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.439

High

869708

AT5G3
ATP synthase F(0) complex subunit C3, mitochondrial

1

1

High-throughput

0.439

High

869715

KR108
Keratin-associated protein 10-8

1

2

High-throughput

0.439

High

869746

LAP4A
Lysosomal-associated transmembrane protein 4A

1

1

High-throughput

0.439

High

869807

RTRAF
RNA transcription, translation and transport factor protein

1

1

High-throughput

0.439

High

869803

APC7
Anaphase-promoting complex subunit 7

1

1

High-throughput

0.437

High

869804

NEB1
Neurabin-1

1

20

High-throughput

0.437

High

869752

Q549M8
RNA transcription, translation and transport factor protein

1

1

High-throughput

0.417

High

869753

Q59HD9
Kelch-like 5 isoform 2 variant

1

3

High-throughput

0.417

High

869756

Q6GSK2
NADPH:adrenodoxin oxidoreductase, mitochondrial

1

2

High-throughput

0.417

High

869757

Q6IBP4
Lysosomal-associated transmembrane protein 4A

1

1

High-throughput

0.417

High

869758

Q6LEU9
ATP synthase lipid-binding protein

1

1

High-throughput

0.417

High

869789

Q9BT63
60S ribosomal protein L3

1

1

High-throughput

0.417

High

869790

ZN350
Zinc finger protein 350

1

2

High-throughput

0.417

High

869800

RHG28
Rho GTPase-activating protein 28

1

10

High-throughput

0.417

High

70140

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

483536

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

2

0

Small-scale

0.313

High

74004

MYO9A
Unconventional myosin-IXa

1

0

High-throughput

0.282

High

278825

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.282

High

426455

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.282

High

869711

EMD
Emerin

1

0

High-throughput

0.282

High

869732

MAMD1
Mastermind-like domain-containing protein 1

1

0

High-throughput

0.282

High

869735

CO9A2

1

0

High-throughput

0.282

High

869749

C27C1
Cytochrome P450 27C1

1

0

High-throughput

0.282

High

869781

CJ090
(E2-independent) E3 ubiquitin-conjugating enzyme FATS

1

0

High-throughput

0.282

High

869794

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

0

High-throughput

0.282

High

869808

PRLD1
PRELI domain-containing protein 1, mitochondrial

1

0

High-throughput

0.282

High

167066

GEMI2
Gem-associated protein 2

1

0

High-throughput

0.265

Low

272900

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.265

Low

318192

DDHD2
Triacylglycerol hydrolase DDHD2

1

0

High-throughput

0.265

Low

333306

SNAPN
SNARE-associated protein Snapin

1

0

High-throughput

0.265

Low

660895

HAP40
40-kDa huntingtin-associated protein

1

0

High-throughput

0.265

Low

727491

ZEP2
Transcription factor HIVEP2

1

0

High-throughput

0.265

Low

869727

LIPS
Hormone-sensitive lipase

1

0

High-throughput

0.265

Low

869737

RBM39
RNA-binding protein 39

1

0

High-throughput

0.265

Low

869742

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.265

Low

869744

PSME4
Proteasome activator complex subunit 4

1

0

High-throughput

0.265

Low

869745

CUL7
Cullin-7

1

0

High-throughput

0.265

Low

869748

WASC4
WASH complex subunit 4

1

0

High-throughput

0.265

Low

869764

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.265

Low

869767

CMIP
C-Maf-inducing protein

1

0

High-throughput

0.265

Low

869771

P66B
Transcriptional repressor p66-beta

1

0

High-throughput

0.265

Low

869774

P2R3C
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

1

0

High-throughput

0.265

Low

869780

ABHEB
Putative protein-lysine deacylase ABHD14B

1

0

High-throughput

0.265

Low

869801

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.265

Low

869811

DDX52
Probable ATP-dependent RNA helicase DDX52

1

0

High-throughput

0.265

Low

869813

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.265

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025