HitPredict

Interactor 1: AMPH (P49418)
Amphiphysin
Gene: AMPH

Interactor 2: BIN2 (Q9UBW5)
Bridging integrator 2 (Breast cancer-associated protein 1)
Gene: BIN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BAR~BAR
Common GO terms	GO:0005543 - phospholipid binding GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 695 Hs			1 565
+	Hs
		883029 AMPH_HUMAN (1-695): 2.85e-138: 423: 100.00		AMPH_HUMAN (6-560): 1.56e-91: 297: 33.10
+	Hs
		138461 AMPH_HUMAN (1-695): 2.85e-138: 423: 100.00		BIN1_HUMAN (1-477): 3.01e-79: 262: 36.91
+	Rn
		148381 AMPH_RAT (1-695): 1.17e-119: 374: 84.75		AMPH_RAT (6-546): 5.9e-93: 300: 30.44
+	Rn
		148382 AMPH_RAT (1-695): 1.17e-119: 374: 84.75		BIN1_RAT (1-455): 6.06e-78: 258: 37.96
+	Hs
		883072 AMPH_HUMAN (1-695): 2.85e-138: 423: 100.00		CABIN_HUMAN (301-561): 4.31e-10: 65.1: 13.01
+	Hs
		215908 AMPH_HUMAN (1-695): 2.85e-138: 423: 100.00		SYNJ1_HUMAN (215-562): 1.03e-09: 63.5: 10.76
+	Dm
		1267295 Q7KLE5_DROME (1-694): 2.15e-65: 228: 22.60		Q7KLE5_DROME (12-409): 7.7e-72: 243: 29.38
+	Hs
		1251245 DNMBP_HUMAN (12-536): 3.52e-59: 218: 18.97		DNMBP_HUMAN (16-506): 6.97e-63: 226: 16.82
+	Rn
		148393 AMPH_RAT (1-695): 1.17e-119: 374: 84.75		SYNJ1_RAT (201-554): 4.89e-09: 61.6: 10.83
+	Hs
		138533 BIN2_HUMAN (8-554): 5.32e-43: 165: 28.96		BIN1_HUMAN (1-477): 3.01e-79: 262: 36.91
+	Hs
		1251271 DNMBP_HUMAN (12-536): 3.52e-59: 218: 18.97		BIN3_HUMAN (31-265): 3.12e-53: 183: 19.67
+	Hs
		138411 BIN1_HUMAN (375-694): 2.11e-33: 138: 22.81		BIN1_HUMAN (1-477): 3.01e-79: 262: 36.91
+	Ca
		1202624 RV161_CANAL (12-241): 8.97e-56: 193: 25.21		RV167_CANAL (15-407): 5.12e-58: 201: 17.07
+	Sc
		672313 RV161_YEAST (11-241): 3.81e-51: 180: 24.69		RV167_YEAST (15-348): 6.3e-53: 189: 17.20
+	Sc
		814193 RV167_YEAST (11-401): 2.15e-44: 168: 15.53		RV167_YEAST (15-348): 6.3e-53: 189: 17.20
+	Hs
		50301 ARH37_HUMAN (13-452): 2.34e-40: 159: 13.42		BIN3_HUMAN (31-265): 3.12e-53: 183: 19.67
+	Dm
		1216726 Q9VLS7_DROME (247-637): 2.12e-41: 165: 18.14		Q5U0V7_DROME (56-520): 1.17e-45: 175: 12.53
+	Rn
		148406 BIN1_RAT (369-695): 2.3e-34: 140: 22.94		SYNJ1_RAT (201-554): 4.89e-09: 61.6: 10.83