HitPredict

Interactor 1: CENPA (P49450)
Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
Gene: CENPA

Interactor 2: CENPC (Q03188)
Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7)
Gene: CENPC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 1.00 0.839

The method score is based on:

Property Details
Experiments 34079125, 16622419, 19503796
Identification Methods proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation, bimolecular fluorescence complementation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CENP-C_mid~Histone
Common GO terms GO:0000779 - condensed chromosome, centromeric region
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005721 - pericentric heterochromatin
and 2 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 140
Hs

1 943
+ Hs
+ Hs
+ Mm
+ Mm
+ Mm
+ Hs
+ Hs
+ Hs
+ Gg
+ Sc
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025