Protein: CENPC
Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7)

Gene: CENPC
Organism: Homo sapiens
Interactions: 118
UniProt ID: Q03188

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0000776 - kinetochore
GO:0000779 - condensed chromosome, centromeric region
GO:0000939 - inner kinetochore
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1041853

MIS12
Protein MIS12 homolog

4

1

High-throughput

0.906

High

883514

CENPA
Histone H3-like centromeric protein A

3

12

Small-scale

0.839

High

1041863

H2AW
Core histone macro-H2A.2

2

12

High-throughput

0.811

High

980709

H2B1C
Histone H2B type 1-C/E/F/G/I

2

15

High-throughput

0.754

High

998235

H31
Histone H3.1

2

12

High-throughput

0.754

High

1041850

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

4

5

High-throughput

0.694

High

446930

NPM
Nucleophosmin

3

3

High-throughput

0.667

High

1041813

CENPC
Centromere protein C

1

5

Small-scale

0.665

High

371818

MYC
Myc proto-oncogene protein

3

6

High-throughput

0.640

High

208239

RRP8
Ribosomal RNA-processing protein 8

3

0

High-throughput

0.634

High

163922

NDC80
Kinetochore protein NDC80 homolog

2

3

High-throughput

0.628

High

841343

RBM34
RNA-binding protein 34

2

3

High-throughput

0.628

High

977679

ACTA
Actin, aortic smooth muscle

2

1

High-throughput

0.628

High

1041829

PMF1
Polyamine-modulated factor 1

2

1

High-throughput

0.628

High

1041848

RBM4
RNA-binding protein 4

2

3

High-throughput

0.628

High

1041851

NUF2
Kinetochore protein Nuf2

2

2

High-throughput

0.628

High

1041855

DSN1
Kinetochore-associated protein DSN1 homolog

2

1

High-throughput

0.628

High

595407

H15
Histone H1.5

2

7

High-throughput

0.621

High

1016790

H33
Histone H3.3

1

12

High-throughput

0.618

High

1041814

RL18
Large ribosomal subunit protein eL18

2

0

High-throughput

0.602

High

1041831

CENPU
Centromere protein U

2

0

High-throughput

0.602

High

1041839

DGCR8
Microprocessor complex subunit DGCR8

2

0

High-throughput

0.602

High

978886

RS6
Small ribosomal subunit protein eS6

2

0

High-throughput

0.585

High

951629

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

4

Small-scale

0.584

High

1041873

CHTOP
Chromatin target of PRMT1 protein

2

0

High-throughput

0.576

High

834431

SYIC
Isoleucine--tRNA ligase, cytoplasmic

2

0

High-throughput

0.559

High

810058

RL3
Large ribosomal subunit protein uL3

2

0

High-throughput

0.547

High

286954

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

7

High-throughput

0.536

High

596055

H12
Histone H1.2

1

7

High-throughput

0.536

High

824111

RL13A
Large ribosomal subunit protein uL13

1

1

High-throughput

0.536

High

890305

NU153
Nuclear pore complex protein Nup153

1

8

High-throughput

0.536

High

911914

JAK3
Tyrosine-protein kinase JAK3

1

4

High-throughput

0.536

High

1041816

ILF3
Interleukin enhancer-binding factor 3

1

4

High-throughput

0.536

High

1041818

SRSF6
Serine/arginine-rich splicing factor 6

1

3

High-throughput

0.536

High

1041825

OASL
2'-5'-oligoadenylate synthase-like protein

1

1

High-throughput

0.536

High

1041832

CENPQ
Centromere protein Q

1

1

High-throughput

0.536

High

1041846

CENPO
Centromere protein O

1

1

High-throughput

0.536

High

1041824

ELOC
Elongin-C

1

0

High-throughput

0.518

High

785114

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

859794

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.513

High

960694

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.513

High

1041843

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

1041866

ZBT47
Zinc finger and BTB domain-containing protein 47

1

0

High-throughput

0.513

High

1041872

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.513

High

1041826

MK14
Mitogen-activated protein kinase 14

1

2

High-throughput

0.508

High

604641

UBF1
Nucleolar transcription factor 1

1

6

Small-scale

0.501

High

329917

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.493

High

1041865

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.486

High

1041837

CIP2A
Protein CIP2A

1

1

Small-scale

0.481

High

140882

NOP56
Nucleolar protein 56

1

1

High-throughput

0.479

High

190882

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

7

High-throughput

0.479

High

254358

CC14B
Dual specificity protein phosphatase CDC14B

1

5

High-throughput

0.479

High

259826

BRD4
Bromodomain-containing protein 4

1

7

High-throughput

0.479

High

285225

EED
Polycomb protein EED

1

6

High-throughput

0.479

High

298364

DNJC8
DnaJ homolog subfamily C member 8

1

4

High-throughput

0.479

High

302812

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

6

High-throughput

0.479

High

461381

HS90A
Heat shock protein HSP 90-alpha

1

2

High-throughput

0.479

High

485083

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

7

High-throughput

0.479

High

487214

PARP1
Poly [ADP-ribose] polymerase 1

1

5

High-throughput

0.479

High

679141

DNJB1
DnaJ homolog subfamily B member 1

1

2

High-throughput

0.479

High

697083

APEX1
DNA repair nuclease/redox regulator APEX1

1

2

High-throughput

0.479

High

799858

COIL
Coilin

1

1

High-throughput

0.479

High

855430

ATRX
Transcriptional regulator ATRX

1

7

Small-scale

0.479

High

1027393

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

5

High-throughput

0.479

High

1041817

CBX3
Chromobox protein homolog 3

1

6

High-throughput

0.479

High

1041821

BRD3
Bromodomain-containing protein 3

1

6

High-throughput

0.479

High

1041822

EEA1
Early endosome antigen 1

1

7

High-throughput

0.479

High

1041823

RNPS1
RNA-binding protein with serine-rich domain 1

1

4

High-throughput

0.479

High

1041834

SMC5
Structural maintenance of chromosomes protein 5

1

6

High-throughput

0.479

High

1041836

NUP43
Nucleoporin Nup43

1

8

High-throughput

0.479

High

1041840

MOB3A
MOB kinase activator 3A

1

2

High-throughput

0.479

High

1041841

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

5

High-throughput

0.479

High

1041845

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.479

High

1041847

DDX23
Probable ATP-dependent RNA helicase DDX23

1

2

High-throughput

0.479

High

1041852

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.479

High

1041859

CENPM
Centromere protein M

1

1

Small-scale

0.479

High

1041861

NLE1
Notchless protein homolog 1

1

1

High-throughput

0.479

High

1041862

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1041867

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1041870

ASF1A
Histone chaperone ASF1A

1

1

High-throughput

0.479

High

1041871

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

1041819

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.460

High

657897

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

982630

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

984725

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

1004468

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1041835

CGAS
Cyclic GMP-AMP synthase

1

0

Small-scale

0.458

High

1041838

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

1041849

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.458

High

1041869

MARE3
Microtubule-associated protein RP/EB family member 3

1

0

High-throughput

0.458

High

741

MEIKN
Meiosis-specific kinetochore protein

1

1

Small-scale

0.457

High

955080

CDC42
Cell division control protein 42 homolog

1

7

Small-scale

0.457

High

288637

NPM3
Nucleoplasmin-3

1

3

High-throughput

0.445

High

601640

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

High-throughput

0.445

High

904624

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.445

High

105789

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

1041833

DHX40
Probable ATP-dependent RNA helicase DHX40

1

4

High-throughput

0.437

High

1041860

DJC17
DnaJ homolog subfamily C member 17

1

5

High-throughput

0.437

High

191616

MAGB2
Melanoma-associated antigen B2

1

0

High-throughput

0.426

High

290536

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.426

High

584086

FOSL2
Fos-related antigen 2

1

0

High-throughput

0.426

High

686110

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.426

High

985620

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.426

High

1037462

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.426

High

1041827

PKHO1
Pleckstrin homology domain-containing family O member 1

1

0

High-throughput

0.426

High

1041830

PSRC1
Proline/serine-rich coiled-coil protein 1

1

0

High-throughput

0.426

High

1041842

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.426

High

1041854

CENPH
Centromere protein H

1

0

High-throughput

0.426

High

1041856

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

1041857

EAF6
Chromatin modification-related protein MEAF6

1

0

High-throughput

0.426

High

1041864

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.426

High

1041868

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.426

High

1041820

MDC1
Mediator of DNA damage checkpoint protein 1

1

8

Small-scale

0.408

High

1041815

FGL1
Fibrinogen-like protein 1

3

0

High-throughput

0.347

High

1041844

CC140
Coiled-coil domain-containing protein 140

1

0

High-throughput

0.279

Low

1041828

TEX30
Testis-expressed protein 30

1

0

High-throughput

0.249

Low

1041858

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025