HitPredict

Interactor 1: RAD50 (P58301)
DNA double-strand break repair Rad50 ATPase (pfRad50)
Gene: RAD50

Interactor 2: RAD50 (P58301)
DNA double-strand break repair Rad50 ATPase (pfRad50)
Gene: RAD50

Species: Pyrococcus furiosus DSM 3638

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.790

Property	Details
Experiments	21441914, 24493214
Identification Methods	pull down, x-ray crystallography, molecular sieving, cross-linking study
Interaction Type	association, direct interaction

Property	Details
Interacting Pfam domains	AAA_21~AAA_21, AAA_21~AAA_23, AAA_23~AAA_23, Rad50_zn_hook~Rad50_zn_hook
Common GO terms	GO:0005524 - ATP binding GO:0006302 - double-strand break repair GO:0008270 - zinc ion binding GO:0016887 - ATP hydrolysis activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 882 Pf			1 882
+	Tm
		1376771 RAD50_THEMA (1-870): 3.37e-41: 165: 18.98		RAD50_THEMA (1-870): 3.37e-41: 165: 18.98
+	Ss
		937685 P73012_SYNY3 (1-882): 1.25e-40: 163: 17.16		P73012_SYNY3 (1-882): 1.25e-40: 163: 17.16
+	Sc
		521101 RAD50_YEAST (196-861): 3.88e-28: 124: 19.11		RAD50_YEAST (196-861): 3.88e-28: 124: 19.11
+	Dm
		1303379 MYSN_DROME (51-725): 8.59e-24: 110: 10.19		MYSN_DROME (51-725): 8.59e-24: 110: 10.19
+	Hs
		724686 MYH9_HUMAN (297-797): 4.94e-22: 105: 11.96		MYH9_HUMAN (297-797): 4.94e-22: 105: 11.96
+	Hs
		522585 MYH7_HUMAN (50-684): 6.36e-22: 104: 12.00		MYH7_HUMAN (50-684): 6.36e-22: 104: 12.00
+	Rn
		222472 MRCKA_RAT (48-518): 3.15e-21: 102: 10.54		MRCKA_RAT (48-518): 3.15e-21: 102: 10.54
+	Hs
		148460 MYH9_HUMAN (297-797): 4.94e-22: 105: 11.96		CTRO_HUMAN (39-664): 5.63e-20: 98.1: 12.38
+	Hs
		528435 MYH8_HUMAN (302-816): 2.88e-22: 105: 15.36		MYH4_HUMAN (36-637): 6.49e-20: 98.1: 12.77
+	Hs
		522657 MYH7_HUMAN (50-684): 6.36e-22: 104: 12.00		MYH4_HUMAN (36-637): 6.49e-20: 98.1: 12.77
+	Hs
		148126 CTRO_HUMAN (39-664): 5.63e-20: 98.1: 12.38		CTRO_HUMAN (39-664): 5.63e-20: 98.1: 12.38
+	Hs
		148466 CTRO_HUMAN (39-664): 5.63e-20: 98.1: 12.38		MYH11_HUMAN (50-598): 1.05e-18: 94.3: 10.41
+	Mm
		93570 MYH9_MOUSE (40-666): 4.66e-24: 111: 11.13		DESP_MOUSE (151-753): 1.85e-14: 80.4: 13.61
+	Hs
		724943 MYH9_HUMAN (297-797): 4.94e-22: 105: 11.96		MY18A_HUMAN (50-488): 2.59e-14: 79.7: 15.35
+	Hs
		149126 CTRO_HUMAN (39-664): 5.63e-20: 98.1: 12.38		MY18A_HUMAN (50-488): 2.59e-14: 79.7: 15.35
+	Hs
		528432 MYH8_HUMAN (302-816): 2.88e-22: 105: 15.36		MYH13_HUMAN (38-444): 1.02e-09: 64.6: 10.65
+	Hs
		724687 MYH9_HUMAN (297-797): 4.94e-22: 105: 11.96		MYH10_HUMAN (50-432): 3.65e-09: 63.1: 10.66
+	Hs
		148359 CTRO_HUMAN (39-664): 5.63e-20: 98.1: 12.38		DESP_HUMAN (148-724): 3.04e-10: 66.6: 14.53
+	Hs
		148461 CTRO_HUMAN (39-664): 5.63e-20: 98.1: 12.38		MYH10_HUMAN (50-432): 3.65e-09: 63.1: 10.66