Interactor 1: TIRAP (P58753)
Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein) (MyD88-2)
Gene: TIRAP

Interactor 2: TIRAP (P58753)
Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein) (MyD88-2)
Gene: TIRAP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.84 0.90 0.871

The method score is based on:

Property Details
Experiments 11544529, 11526399, 21873236, 17258210, 24275656
Identification Methods two hybrid, anti tag coimmunoprecipitation, x-ray crystallography, mammalian protein protein interaction trap
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains TIR_2~TIR_2
Common GO terms GO:0002755 - MyD88-dependent toll-like receptor signaling pathway
GO:0005080 - protein kinase C binding
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 42 others

more...

Homologous interactions 0

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024